New drug combo targets breathing pauses in sleep apnea

NCT ID NCT06776432

Ongoing Symptom relief Sponsor: Shionogi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2A study tests three drugs—sivopixant, acetazolamide, and SASS-001—in 60 adults with sleep apnea that has a central component (where the brain fails to signal breathing). The goal is to see if these drugs can reduce the number of breathing pauses during sleep. Participants have conditions like heart failure or atrial fibrillation. The study compares each drug against a placebo to measure safety and effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sivopixant, acetazolamide, and SASS-001 (drugs)
What this could lead to: If successful, this could point toward new medication options to reduce breathing pauses during sleep for people with central sleep apnea.
What could go wrong: This is an early Phase 2A trial with only 60 participants, so results may not apply to everyone. The drugs may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

central sleep apnea syndrome obstructive sleep apnea syndrome sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SLEEP APNEA

Contacts and locations

Locations

Altman Clinical and Translational Research Institute (ACTRI)

La Jolla, California, 92037, United States
Huntsville Research Institute LLC

Huntsville, Texas, 77340, United States
Infinity Medical Research

North Dartmouth, Massachusetts, 02747, United States
Intrepid Research, LLC

Cincinnati, Ohio, 45245, United States
John D. Dingell VA Medical Center

Detroit, Michigan, 48201, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
OnSite Clinical Solutions

Rock Hill, South Carolina, 29732, United States
PharmaDev Clinical Research Institute, LLC

Miami, Florida, 33176, United States
Teradan Clinical Trials

Brandon, Florida, 33511, United States

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