New pill aims to keep narcolepsy patients awake and steady
NCT ID NCT07540897
First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times
Summary
This phase 3 trial tests whether a daily tablet called ALKS 2680 can reduce severe daytime sleepiness and sudden muscle weakness (cataplexy) in adults with narcolepsy type 1. About 150 participants will receive either the drug or a placebo for 12 weeks. The study measures improvements in staying awake and overall symptom severity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ALKS 2680 (alixorexton) tablets
- What this could lead to
- If successful, this could provide a new daily medication to better control excessive daytime sleepiness and sudden muscle weakness in people with narcolepsy type 1.
- What could go wrong
- This is a phase 3 trial, but it is still experimental. The drug may not work better than a placebo, and side effects are possible. It is not a cure, and long-term safety is not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Alkermes Investigational Site
RECRUITINGMiami, Florida, 33176, United States
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Alkermes Investigational Site
RECRUITINGWinter Park, Florida, 32789, United States
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Alkermes Investigational Site
RECRUITINGAtlanta, Georgia, 30328, United States
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Alkermes Investigational Site
RECRUITINGMacon, Georgia, 31210, United States
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Alkermes Investigational Site
RECRUITINGLansing, Michigan, 48911, United States
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Alkermes Investigational Site
RECRUITINGSt Louis, Missouri, 63123, United States
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Alkermes Investigational Site
RECRUITINGCharlotte, North Carolina, 28210, United States
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Alkermes Investigational Site
RECRUITINGCincinnati, Ohio, 45245, United States
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Alkermes Investigational Site
RECRUITINGColombia, South Carolina, 29201, United States
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Alkermes Investigational Site
RECRUITINGDallas, Texas, 75251, United States
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Alkermes Investigational Site
RECRUITINGSan Antonio, Texas, 78229, United States
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Alkermes Investigational Site
RECRUITINGSugar Land, Texas, 77478, United States
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Alkermes Investigational Site
RECRUITINGMarkham, Ontario, L3R 1A3, Canada
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Alkermes Investigational Site
RECRUITINGToronto, Ontario, M5S 3A3, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Do current sleepiness tests work for kids? a new study puts them to the test
- Zapping the Brain's deep centers: a new approach to narcolepsy?
- New test could sharpen diagnosis of narcolepsy and related sleep disorders
- New pill aims to tame Narcolepsy's sleep attacks and sudden muscle weakness
- Dream control: a new behavioral approach to tame narcolepsy nightmares
- New drug TAK-360 tested for Long-Term safety in sleep disorders