Can a common arthritis drug stop Parkinson's before it starts?

NCT ID NCT06996652

Recruiting now Prevention Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This study tests whether adalimumab, an anti-inflammatory drug, can prevent brain changes linked to Parkinson's disease in 108 people with REM sleep behavior disorder (RBD). RBD often precedes Parkinson's. Participants will receive adalimumab or a placebo every two weeks for two years, and researchers will monitor brain activity using PET scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Adalimumab (a drug that reduces inflammation, given as a shot every 2 weeks)
What this could lead to: If it works, this could point toward a way to delay or prevent Parkinson's disease in people with REM sleep behavior disorder.
What could go wrong: This is an early phase 2 study with only 108 people. It tests a brain scan change, not whether symptoms actually improve. Adalimumab can increase infection risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

REM sleep behavior disorder synucleinopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REM SLEEP BEHAVIOR DISORDER

Contacts and locations

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Locations

Beth Israel Deaconess Medical Center
NOT_YET_RECRUITING

Boston, Massachusetts, 02215, United States
Cedars Sinai Medical Center
NOT_YET_RECRUITING

Los Angeles, California, 90048, United States
Cleveland Clinic Lou Ruvo Center for Brain Health - Las Vegas
NOT_YET_RECRUITING

Las Vegas, Nevada, 89106, United States
Dartmouth Hitchcock Medical Center
NOT_YET_RECRUITING

Lebanon, New Hampshire, 03756, United States
Emory University School of Medicine
NOT_YET_RECRUITING

Atlanta, Georgia, 30329, United States
Johns Hopkins University
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Medical University of South Carolina
NOT_YET_RECRUITING

Charleston, South Carolina, 29403, United States
Montreal Neurological Institute-Hospital at McGill University
NOT_YET_RECRUITING

Montreal, Quebec, H3A 2B4, Canada
Oregon Health & Science University
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Parkinson's Disease & Movement Disorders Center of Boca Raton
NOT_YET_RECRUITING

Boca Raton, Florida, 33486, United States
University of Colorado Anschutz
RECRUITING

Aurora, Colorado, 80045, United States
University of Minnesota
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55414, United States
University of Pennsylvania
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University of Texas Health Science Center- San Antonio
NOT_YET_RECRUITING

San Antonio, Texas, 78229, United States
University of Texas Houston Medical Center
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Washington University
NOT_YET_RECRUITING

St Louis, Missouri, 63110, United States
Weill Medical College of Cornell University
NOT_YET_RECRUITING

New York, New York, 10021, United States
Yale Medicine
NOT_YET_RECRUITING

North Haven, Connecticut, 06473, United States

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