Can a common arthritis drug stop Parkinson's before it starts?
NCT ID NCT06996652
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 38 times
Summary
This study tests whether adalimumab, an anti-inflammatory drug, can prevent brain changes linked to Parkinson's disease in 108 people with REM sleep behavior disorder (RBD). RBD often precedes Parkinson's. Participants will receive adalimumab or a placebo every two weeks for two years, and researchers will monitor brain activity using PET scans.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Cedars Sinai Medical Center
Los Angeles, California, 90048, United States
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Cleveland Clinic Lou Ruvo Center for Brain Health - Las Vegas
Las Vegas, Nevada, 89106, United States
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Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
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Emory University School of Medicine
Atlanta, Georgia, 30329, United States
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Johns Hopkins University
Baltimore, Maryland, 21287, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Medical University of South Carolina
Charleston, South Carolina, 29403, United States
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Montreal Neurological Institute-Hospital at McGill University
Montreal, Quebec, H3A 2B4, Canada
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Parkinson's Disease & Movement Disorders Center of Boca Raton
Boca Raton, Florida, 33486, United States
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University of Colorado Anschutz
Aurora, Colorado, 80045, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Minnesota
Minneapolis, Minnesota, 55414, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19107, United States
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University of Texas Health Science Center- San Antonio
San Antonio, Texas, 78229, United States
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University of Texas Houston Medical Center
Houston, Texas, 77030, United States
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Washington University
St Louis, Missouri, 63110, United States
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Weill Medical College of Cornell University
New York, New York, 10021, United States
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Yale Medicine
North Haven, Connecticut, 06473, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Adalimumab (a drug that reduces inflammation, given as a shot every 2 weeks)
What this could lead to
If it works, this could point toward a way to delay or prevent Parkinson's disease in people with REM sleep behavior disorder.
What could go wrong
This is an early phase 2 study with only 108 people. It tests a brain scan change, not whether symptoms actually improve. Adalimumab can increase infection risk.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.