Gout

This study tested whether a gout medication (pegloticase) given every 4 weeks works as well as the standard every-2-week schedule, when both are paired with weekly methotrexate. The goal was to lower uric acid levels in people with severe, hard-to-treat gout. About 262 adults wit…

This completed study tested whether a probiotic supplement called LUA Probiotics can lower uric acid levels in the blood. Twenty adults with high uric acid or gout who were not taking uric acid-lowering drugs took the supplement daily for 28 days. Researchers measured uric acid a…

This completed study tested a new drug called dotinurad in 20 U.S. adults with gout and high uric acid. Researchers looked at how the drug works in the body, both alone and when taken with the standard gout medicine allopurinol. The goal was to understand dosing and potential dru…

This study tested a gout medication called pegloticase (KRYSTEXXA) given every 4 weeks along with weekly methotrexate pills in 54 adults with severe gout that didn't respond to standard treatments. The goal was to see if this combination could lower uric acid levels and keep them…

This Phase 3 study tested AR882, a drug designed to lower uric acid levels in people with gout. Over 800 participants took either a 50 mg or 75 mg dose of AR882 or a placebo daily for 12 months. The main goal was to see if AR882 could bring uric acid below 6 mg/dL at 6 months, wh…

This Phase 3 trial tested a new drug called epaminurad against the standard gout medication febuxostat in 612 adults with gout. The goal was to see if epaminurad could lower uric acid levels more effectively and safely. The study is complete, but results are not yet available.

This early-stage trial tested an experimental drug called HEC93077 in 126 healthy volunteers and people with high uric acid (gout). The goal was to check safety, how the body processes the drug, and the effect of food. Participants took single or multiple doses for up to 14 days.…

This study tested a new drug, ABP-671, for people with gout. Gout causes painful joint swelling due to high uric acid levels. The trial involved 300 adults and compared different doses of ABP-671 to a placebo and an older drug called allopurinol. The main goal was to see if ABP-6…

This study tested a new medicine called LC350189 in 156 adults with gout and high uric acid. The goal was to see if different doses could safely lower uric acid below target levels over 12 weeks. Participants took the drug or a placebo, and researchers measured uric acid in the b…

This study tested a new medicine called SEL-212 for people with chronic gout that doesn't get better with standard treatments. 153 adults received either one of two doses of SEL-212 or a placebo every 28 days for about 6 months. The goal was to see if the drug could lower uric ac…

This early-stage study tested whether a drug called rituximab could help people with severe, hard-to-treat gout respond again to a medication (pegloticase) that had stopped working for them. Only 2 people took part, and the main goal was to see if the approach was safe and possib…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a new medicine called tigulixostat in 354 adults with gout and high uric acid. Participants took one of three doses or a placebo for 6 months. The main goal was to see if the drug could keep uric acid below a target level. The trial is complete and results will …

This study tested whether giving the gout drug pegloticase over a shorter time is safe and works well for people with uncontrolled gout. About 191 adults with hard-to-treat gout received methotrexate before and during pegloticase infusions for up to 24 weeks. The main goal was to…

This study tested a new tablet called HR091506 in 765 adults with gout and high uric acid. The goal was to see if it could lower uric acid levels better than an existing drug, febuxostat. Participants took the medicine for 28 weeks, and doctors checked their uric acid levels regu…

This Phase 3 trial tested a drug called SEL-212 in 112 adults with chronic gout that didn't improve with standard treatments. Participants received either a low or high dose of SEL-212 or a placebo by IV infusion every 28 days for about 6 months. The main goal was to see if the d…

This early study tested a single injection of a new drug, LEO 158968, in 6 people having a gout flare. The goal was to see if it could reduce joint pain. The trial is complete, but results are not yet public.

This study tested a drug called rhTNFR-Fc (similar to etanercept) combined with methylprednisolone in 26 adults with acute gout. The goal was to see if it safely reduces joint pain and delays the next flare-up. Participants received two injections over five days, and researchers …

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, rheumatoid arthritis, osteoarthritis, or lupus. Participants followed a 6-week walking program delivered by phone, and researchers measured changes in pain, ph…

This Phase 3 trial tested whether Qingzhu Granules, a traditional Chinese herbal medicine, can reduce pain from acute gouty arthritis. 472 adults with a gout flare took either the granules or a placebo for 72 hours. The main goal was to see if pain scores improved more with the r…

This completed study from France examined joint fluid from 20 people with arthritis to see if acid-sensing ion channels (ASICs) play a role in pain. Researchers wanted to find natural compounds that activate these channels during inflammation. The goal is to validate ASICs as tar…

This study looked at 33 Polynesian adults with and without gout to find genetic clues about why the disease is so common in this group. Researchers compared family members with gout to those without, using genetic tests and CT scans to measure uric acid crystal deposits. The goal…

This study looked at how well two types of imaging—ultrasound and dual-energy CT (DECT)—agree when measuring urate crystal deposits in people with gout. Sixty adults starting urate-lowering therapy were scanned at the start and again after 6, 12, and 24 months. The goal was to se…

This study aimed to find out how many people in French Polynesia have gout and what genetic factors might be involved. Over 1,000 adults from several islands took part. Researchers measured gout rates and analyzed DNA to look for related genes. The goal was to better understand w…

This study looked at whether people who donate a kidney have a higher chance of developing gout later in life compared to similar healthy people who did not donate. Researchers reviewed health records from 50,000 donors and matched non-donors in Canada over many years. The goal i…

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study looked at health records from nearly 295,000 older adults with gout to see if two common gout medications, probenecid and allopurinol, affect the risk of developing dementia or Alzheimer's disease. The goal was to find out if one drug might be better at protecting the …

This study looked at 225 adults with a rare, inherited form of kidney disease to find the genetic causes. Participants had chronic kidney failure and often had a family history of gout. Researchers tested for known gene mutations and searched for new ones in families without a cl…

This study tested a new skin patch system called UR+AIMS that measures uric acid levels in people with gout. Six participants wore the patch for a week and during a standard meal to see if it was comfortable and gave accurate readings. The goal is to help patients better understa…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study looked at how common joint pain and swelling are in 100 nursing home residents aged 65 and older, both with and without dementia. Researchers performed a physical exam and used simple pain questions or a special checklist for those with severe dementia. The goal was to…

This completed study followed over 18,000 Taiwanese Buddhists to see if a vegetarian diet is linked to a lower risk of chronic diseases like dementia, depression, heart disease, stroke, gout, cataracts, gallstones, and urinary tract infections. Researchers compared health records…