Gout

This study compares starting dotinurad, a urate-lowering drug, during an acute gout flare versus waiting until the flare resolves. About 142 adults with gout will be randomly assigned to one of two timing schedules. Researchers will measure how quickly the flare resolves and whet…

This study will follow 264 adults with frequent gout flares to see how often attacks return within 24 weeks after starting firsekibart. Researchers will also track side effects and how quickly flares resolve. The goal is to understand if this medication helps control gout in ever…

This study looks at whether taking Firsekibart regularly (every 4 weeks) is better than using it only when a gout flare starts. It involves 118 adults who had no flares during 24 weeks of initial treatment. The goal is to see which approach prevents more gout attacks over the nex…

This study tests whether a probiotic-uricase supplement can safely lower uric acid levels in people with hyperuricemia. 45 adults will take the supplement for 2 weeks, and researchers will track changes in uric acid, gut bacteria, and related metabolites. The goal is to see if th…

This early-stage trial tests a new mRNA medicine called IN026 in 16 adults with refractory gout — gout that doesn't get better with standard treatments. The drug is given as an IV infusion and is designed to lower uric acid levels and shrink uric acid crystals (tophi). The main g…

This Phase 2 trial tests BR2251, a new daily tablet, in 160 adults with gout and high uric acid. Participants receive one of three doses of BR2251 or the standard drug febuxostat for 12 weeks. The goal is to see which dose best lowers uric acid levels and reduces gout flare-ups.

This study tests whether having a pharmacist guide gout medication adjustments through regular telehealth visits can improve outcomes compared to usual care. It will enroll 310 veterans at five VA medical centers and follow them for up to two years. The goal is to lower uric acid…

This study tests whether adding the weight-loss drug orlistat to standard gout treatment helps obese patients lower uric acid levels and reduce gout attacks. 120 adults with gout and obesity will take either orlistat or a placebo for 24 weeks, along with diet and exercise advice.…

This study will compare cycling and jogging in 90 adults with gout who have had ankle attacks. Participants will continue standard urate-lowering medication and exercise moderately for 45-60 minutes per session. Researchers will track gout flare frequency, blood uric acid levels,…

Rheumatoid arthritis and gout can look alike, making them hard to tell apart early. This study will use ultrasound to see if it can reliably distinguish between the two conditions. Researchers will examine 100 adults with suspected or confirmed arthritis, scoring joint inflammati…

This study tests whether a genetic test can prevent rare but severe skin reactions caused by the common gout drug allopurinol. About 228 Vietnamese adults with gout will either get the test before treatment or receive standard care. Those with a high-risk gene will take a differe…

This early-stage trial is testing a new drug called F-02-2-Na, designed to lower uric acid levels in people with gout or high uric acid. The study will give 12 healthy adults a single dose of the drug, once on an empty stomach and once after a meal, to see if food changes how the…

This early-stage study looks at how a single dose of a probiotic supplement changes gene activity and sugar patterns in the small intestine of 8 healthy adults. Participants will take the probiotic alone, with fiber, or a placebo, then have a small tissue sample taken the next mo…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …