New gout drug aims to crush uric acid and shrink painful tophi

NCT ID NCT07089888

Recruiting now Disease control Sponsor: Crystalys Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests a new medicine called dotinurad against the standard drug allopurinol in 250 adults with tophaceous gout (gout with hard lumps under the skin). The main goal is to see if dotinurad lowers uric acid levels better after 24 weeks. Researchers will also check if tophi shrink over 76 weeks. Participants must be 18-75, have had gout for at least a year, and have at least one measurable tophus.

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Conditions

The condition(s) this trial relates to.

gout Hyperuricemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOPHACEOUS GOUT

Contacts and locations

Locations

A. Alfred Taubman Health Care Center
RECRUITING

Ann Arbor, Michigan, 48109, United States
Acclaim Clinical Research, Inc.
RECRUITING

San Diego, California, 92120, United States
Alabama Clinical Therapeutics
WITHDRAWN

Birmingham, Alabama, 35235, United States
Alliance Clinical Lewisville (Epic Clinical Research)
RECRUITING

Lewisville, Texas, 75057, United States
Amicis Research Center - Balboa
RECRUITING

Northridge, California, 91324, United States
Anchor Medical Research, LLC
RECRUITING

Miami, Florida, 33176, United States
Arizona Arthritis & Rheumatology Associates (AARA) - Gilbert
RECRUITING

Gilbert, Arizona, 85297, United States
Arizona Arthritis & Rheumatology Associates (AARA) - Glendale
RECRUITING

Glendale, Arizona, 85306, United States
Arizona Arthritis & Rheumatology Associates (AARA) - Mesa
RECRUITING

Mesa, Arizona, 85210, United States
Arthritis & Osteoporosis Center of Coastal Bend
RECRUITING

Corpus Christi, Texas, 78415, United States
BTC Network - Encompass Clinical Research
RECRUITING

Spring Valley, California, 91978, United States
Best Quality Research
RECRUITING

Hialeah, Florida, 33016, United States
Bradenton Research Center
RECRUITING

Bradenton, Florida, 34205, United States
Charlottesville Medical Research
RECRUITING

Charlottesville, Virginia, 22911, United States
Chicago Clinical Research Institute, Inc. (CCRII)
RECRUITING

Chicago, Illinois, 60607, United States
Clinical Research Institute of Michigan - St. Clair Shores
RECRUITING

Saint Clair Shores, Michigan, 48081, United States
Clinical Research Trials of Florida
RECRUITING

Tampa, Florida, 33607, United States
Clinical Research of Center Florida
RECRUITING

Lakeland, Florida, 33805, United States
Coastal Carolina Research Center - Main
RECRUITING

North Charleston, South Carolina, 29405, United States
Cohen Medical Centers
RECRUITING

Thousand Oaks, California, 91360-3967, United States
Conquest Research - Winter Park
RECRUITING

Winter Park, Florida, 32789, United States
Cure Clinical Research, LLC
RECRUITING

Orange, California, 92866, United States
D&H Pompano Research Center
RECRUITING

Margate, Florida, 33063, United States
DM Clinical Research - Detroit
WITHDRAWN

Southfield, Michigan, 48076, United States
DM Clinical Research - Tomball - Multiple Specialties
RECRUITING

Tomball, Texas, 77375, United States
Del Sol Research Management - Tucson East
RECRUITING

Tucson, Arizona, 85715, United States
DelRicht Research
RECRUITING

Charlotte, North Carolina, 28210, United States
DelRicht Research - Atlanta
WITHDRAWN

Atlanta, Georgia, 30329, United States
DelRicht Research - Hendersonville
WITHDRAWN

Hendersonville, Tennessee, 37075, United States
DelRicht Research - LCMC Health Urgent Care - Lakeview
RECRUITING

New Orleans, Louisiana, 70124, United States
DelRicht Research - Louisville (Derby City DPC)
RECRUITING

Louisville, Kentucky, 40205, United States
DelRicht Research - Maryland (Matthew L. Mintz, MD, FACP)
WITHDRAWN

Rockville, Maryland, 20852, United States
DelRicht Research - Prairieville
RECRUITING

Prairieville, Louisiana, 70769, United States
DelRicht Research - Town and Country
RECRUITING

Town and Country, Missouri, 63017, United States
DelRicht Research - Tulsa
WITHDRAWN

Tulsa, Oklahoma, 74133, United States
Delricht Research - Better Life Direct Primary Care
WITHDRAWN

Indianapolis, Indiana, 46202, United States
Delricht Research - Command Family Medicine
WITHDRAWN

Springfield, Missouri, 65807, United States
Delricht Research - Concierge And Direct Primary Care
RECRUITING

Overland Park, Kansas, 66223, United States
Delricht Research - Concierge Medicine Of Cincinnati
WITHDRAWN

Mason, Ohio, 45040, United States
Denver Arthritis Clinic - Lowry
RECRUITING

Denver, Colorado, 80230, United States
Digestive Health Research of North Texas
RECRUITING

Wichita Falls, Texas, 76301, United States
Discovery Clinical Trials
RECRUITING

San Antonio, Texas, 78229, United States
Dream Team Clinical Research
WITHDRAWN

Pomona, California, 91767, United States
ERG - Endeavor Clinical Trials
RECRUITING

San Antonio, Texas, 78240, United States
East Bay Rheumatology Medical Group
RECRUITING

San Leandro, California, 94578, United States
Ellipsis Research Group
RECRUITING

Brooklyn, New York, 11215, United States
Epic Medical Research - DeSoto
RECRUITING

DeSoto, Texas, 75115, United States
Epic Medical Research - Hurst
RECRUITING

Hurst, Texas, 76054, United States
Epic Medical Research - San Marcos
RECRUITING

San Marcos, Texas, 78666, United States
Flourish Chicago - Ravenswood (Great Lakes Clinical Trials)
RECRUITING

Chicago, Illinois, 60640, United States
G & L Research
RECRUITING

Foley, Alabama, 36535, United States
Gershon Pain Specialists
RECRUITING

Virginia Beach, Virginia, 23454, United States
Health Awareness Inc
RECRUITING

Jupiter, Florida, 33458, United States
Health Concepts
RECRUITING

Rapid City, South Dakota, 57702, United States
Herco Medical and Research Center, Inc
RECRUITING

Coral Gables, Florida, 33134, United States
Hometown Urgent Care and Research - Dayton
RECRUITING

Dayton, Ohio, 45424, United States
Infinity Clinical Research
RECRUITING

Norco, California, 92860, United States
Las Vegas Clinical Trials
RECRUITING

North Las Vegas, Nevada, 89030, United States
Lone Star Arthritis & Rheumatology Associates - Denton
RECRUITING

Denton, Texas, 76205, United States
MD Medical Research - Oxon Hill
RECRUITING

Oxon Hill, Maryland, 20745, United States
MedVadis Research
RECRUITING

Waltham, Massachusetts, 02451, United States
MediSphere Medical Research Center, LLC - East
RECRUITING

Evansville, Indiana, 47714, United States
Medvin Clinical Research - Covina
RECRUITING

Covina, California, 91722, United States
Medvin Clinical Research - Tujunga
RECRUITING

Tujunga, California, 91042, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
New Generation of Medical Research
RECRUITING

Hialeah, Florida, 32016, United States
Oakland Medical Center
RECRUITING

Troy, Michigan, 48085, United States
Omega Research DeBary
RECRUITING

Orlando, Florida, 32808, United States
Panax Clinical Research
RECRUITING

Miami Lakes, Florida, 33014, United States
Pioneeer Research Solutions
RECRUITING

Houston, Texas, 77099, United States
Premier Health Research
RECRUITING

Sparta, New Jersey, 07871, United States
Premise Clinical Research Center
RECRUITING

Lancaster, Texas, 75146, United States
Prolato Clinical Research Center
RECRUITING

Houston, Texas, 77027, United States
R & H Clinical Research - South Fry Road
RECRUITING

Katy, Texas, 77450, United States
Revival Research Institute - Sterling Heights
RECRUITING

Sterling Heights, Michigan, 48313, United States
Rio Clinical Trials - Corporate Office
RECRUITING

Ogden, Utah, 84404, United States
Sahni Rheumatology & Therapy
RECRUITING

West Long Branch, New Jersey, 07764, United States
Shelby Clinical Research, LLC - North Carolina
RECRUITING

Shelby, North Carolina, 28150, United States
Siena Research Network
RECRUITING

Sugar Land, Texas, 77479, United States
Southland Arthritis and Osteoporosis Medical Center, Inc
RECRUITING

Menifee, California, 92586, United States
Southwest Rheumatology Research
RECRUITING

Mesquite, Texas, 75150, United States
Suburban Research Associates - West Chester Office
WITHDRAWN

West Chester, Pennsylvania, 19380, United States
Tandem Clinical Research - Metairie Clinic
ACTIVE_NOT_RECRUITING

Metairie, Louisiana, 70006, United States
The Kirklin Clinic of University of Alabama Birmingham Hospital
RECRUITING

Birmingham, Alabama, 35233, United States
Triad Clinical Trials
RECRUITING

Greensboro, North Carolina, 27410, United States
Velocity Clinical Research - San Bernardino
RECRUITING

San Bernardino, California, 92408, United States
Well Pharma Medical Research
RECRUITING

Miami, Florida, 33173, United States
West Coast Research
RECRUITING

Dublin, California, 94568, United States
Zenos Clinical Research
RECRUITING

Dallas, Texas, 75230, United States

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