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New hope for tough gout: drug combo targets uric acid after other treatments fail

NCT ID NCT07116746

Ongoing Disease control Sponsor: Arthrosi Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new drug called AR882, taken with a standard gout medication (XOI), in 15 people with severe, uncontrolled gout who have already failed uricase therapy. The goal is to see if the combination can lower uric acid levels and shrink painful uric acid crystal deposits called tophi. Researchers will also monitor for side effects over 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
AR882 (a drug that lowers uric acid) combined with a xanthine oxidase inhibitor (XOI)
What this could lead to
If it works, this could offer a new treatment option for people with severe gout who have not responded to or cannot tolerate uricase therapy.
What could go wrong
This is a small, early-phase trial with only 15 participants, so results may not apply to everyone. The drug combination may cause side effects or fail to control gout long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Arthritis, Gouty gout Hyperuricemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GOUT GOUT CHRONIC GOUTY ARTHRITIS HYPERURICEMIA REFRACTORY GOUT TOPHACEOUS GOUT UNCONTROLLED GOUT

Contacts and locations

Locations

  • Arthrosi Investigative Site (102)

    Miami, Florida, 33155, United States

  • Arthrosi Investigative Site (103)

    Duncansville, Pennsylvania, 16635, United States

  • Arthrosi Investigative Site (104)

    West Lake Hills, Texas, 78746, United States

  • Arthrosi Investigative Site (105)

    Margate, Florida, 33063, United States

  • Arthrosi Investigative Site (106)

    Jackson, Mississippi, 39202, United States

  • Arthrosi Investigative Site (107)

    Bellevue, Washington, 98004, United States

  • Arthrosi Investigative Site (108)

    Charlotte, North Carolina, 28202, United States

  • Arthrosi Investigative Site (109)

    Tampa, Florida, 33609, United States

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