New CT scan reveals how gout treatments melt crystal deposits
NCT ID NCT03965676
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study follows 50 adults with tophaceous gout who are starting or adjusting urate-lowering therapy. Researchers use a special CT scan (Dual-Energy CT) to measure how much the uric acid crystals in tophi shrink after 6 and 12 months of treatment. They also check whether bone erosions heal as the tophi get smaller. The goal is to better understand why some tophi dissolve faster than others and which locations respond best.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
urate-lowering therapy
What this could lead to
If successful, this could help doctors predict which gout patients will respond best to treatment and whether tophus shrinkage can repair bone damage.
What could go wrong
This is a small observational study (50 people) with no control group, so results may not apply broadly. It measures imaging changes, not direct patient outcomes like pain or quality of life.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Radiology Department Lariboisière Hospital
Paris, Île-de-France Region, 75010, France
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Reumatology Department Lariboisière Hospital
Paris, Île-de-France Region, 75010, France