Amgen

This was a very early, first-in-human study to test the safety and find the right dose of an experimental drug called AMG 794. It was for adults with advanced or spreading cancers that have a specific marker called Claudin 6 (CLDN6), including certain lung and ovarian cancers. Th…

This was an early safety study of a new drug called AMG 199 for adults with advanced stomach, colon, or pancreatic cancers that have a specific marker called MUC17. The main goals were to find a safe dose and see how the body handles the drug. The treatment aims to guide the pati…

This study tested an experimental oral drug called HZN-825 to see if it could slow the progression of lung scarring in people with idiopathic pulmonary fibrosis (IPF). About 153 participants were randomly assigned to receive either the drug at one of two doses or a placebo for on…

This study tested several new drug combinations for men with advanced prostate cancer that had spread and was no longer responding to standard hormone therapy. The main goals were to find safe doses and see if the treatments could help control the cancer. The trial was terminated…

This trial tested an investigational drug called HZN-825 in adults with a severe form of systemic sclerosis, a disease that causes skin thickening and can damage the lungs. About 300 participants received either the drug or a placebo for one year to see if it could improve lung f…

This study aimed to check the long-term safety and see if a drug called efavaleukin alfa could help control symptoms of moderate to severe ulcerative colitis over one to two years. It was for 25 people who had already completed a previous 52-week study with the drug. The trial ha…

This early-stage study tested a new drug called AMG 701, both alone and combined with other medications, for adults with multiple myeloma that had returned or stopped responding to many prior treatments. The main goals were to find a safe and effective dose and to see how the bod…

This study tested a new drug called efavaleukin alfa in adults with moderate to severe ulcerative colitis, a chronic bowel disease. The main goal was to see if the drug could help patients achieve remission, meaning their symptoms and bowel inflammation went away. The trial was d…

This extension study followed patients who completed a previous trial to continue testing the experimental drug HZN-825 for an additional year. It aimed to see if the drug could help preserve lung function in people with diffuse cutaneous systemic sclerosis, a rare autoimmune dis…

This study tested whether a new injectable medication called daxdilimab could reduce skin disease activity in adults with moderate-to-severe discoid lupus, a condition causing scarring skin rashes. About 72 participants received either the drug or a placebo shot every four weeks …

This was an early-stage study to find a safe and effective dose of an experimental drug called AMG 420 for people with multiple myeloma that had returned or stopped responding to at least three prior types of therapy. The trial involved 23 participants who received the drug throu…

This was an early safety study for a new drug called acapatamab, designed to help the body's own immune cells attack advanced prostate cancer. It involved 212 men whose cancer had spread and was no longer responding to standard hormone and chemotherapy treatments. The main goal w…

This early-stage study aimed to check the safety of a new drug called AMG 378 and see how the body absorbs and processes it. It involved 48 healthy adults who received either the drug or a placebo. The trial was terminated, meaning it was stopped early, and its main goal was to g…