Amgen

This study tested the long-term safety of a drug called efavaleukin alfa in people with moderate to severe ulcerative colitis. It was designed for patients who completed a previous year-long study and might benefit from continued treatment. However, the study was terminated early…

This study tested an experimental drug called HZN-825 in people with idiopathic pulmonary fibrosis (IPF), a serious lung disease that causes scarring and makes breathing hard. The trial aimed to see if the drug could slow lung function decline over 52 weeks. About 153 adults with…

This study tested an experimental drug called HZN-825 in about 300 people with a rare autoimmune disease that causes skin thickening and can harm the lungs. The trial was stopped early, so results are not available. Participants took the drug or a placebo daily for up to 52 weeks…

This early-stage study tested a new drug called AMG 199 in adults with advanced stomach, esophageal, colorectal, or pancreatic cancers that have a specific marker (MUC17). The main goals were to check safety and find the right dose. The study was stopped early, so results are lim…

This study aimed to test the safety and effectiveness of new drugs for men with a type of advanced prostate cancer that no longer responds to hormone therapy. It enrolled 65 adults with confirmed cancer. The study was terminated early, so results are limited.

This early-stage study tested a new drug called acapatamab in 212 men with metastatic castration-resistant prostate cancer that had stopped responding to standard therapies. The drug works by directing the body's immune cells to attack cancer cells. The main goals were to check s…

This study tested an experimental drug called HZN-825 in people with a severe form of scleroderma that affects the skin and lungs. The trial was stopped early, but researchers measured changes in lung function and tracked side effects over 52 weeks. Participants had already compl…

This study tested an investigational drug called daxdilimab in 72 adults with moderate-to-severe discoid lupus erythematosus (DLE), a skin condition that causes scarring and hair loss. The goal was to see if the drug could reduce disease activity compared to a placebo. However, t…

This early-stage study tested the drug AMG 420 in 23 people with multiple myeloma that had returned or stopped responding to at least three prior treatments. The goal was to find a safe dose and check for side effects. The study was stopped early, and results focused on safety an…

This study tested an experimental drug called AMG 701, alone or with other medicines, in 174 adults with multiple myeloma that had come back or stopped responding to prior treatments. The main goals were to check safety and find the best dose. The trial was stopped early, so resu…

This was a very early (Phase 1) study testing a new drug called AMG 794 in adults with advanced lung, ovarian, or other solid tumors that had a specific marker (claudin 6). The main goal was to check safety and find the right dose. The study was stopped early after only 3 people …

This study tested a new drug called efavaleukin alfa for people with moderate to severe ulcerative colitis, a condition causing inflammation in the colon. About 221 adults took part, receiving either the drug or a placebo for 12 weeks, with an option to continue treatment for up …

This early-phase study tested the safety of a new drug called AMG 378 in 48 healthy adults aged 18 to 55. Participants received either the drug or a placebo to check for side effects and how the drug moves through the body. The study was terminated early, and no treatment or heal…