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New hope for stomach cancer: targeted drug combo enters human trials

NCT ID NCT05322577

Terminated Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

This study tests a new drug called bemarituzumab, given together with chemotherapy and an immunotherapy drug (nivolumab), in 72 adults with advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery. The main goals are to check safety and see if the combination shrinks tumors. The trial is for people whose tumors have not been treated before and who have a specific protein (FGFR2b) on their cancer cells.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
bemarituzumab (a targeted antibody) combined with chemotherapy (CAPOX or SOX) and the immunotherapy nivolumab
What this could lead to
If successful, this could lead to a new combination treatment option for people with advanced stomach or gastroesophageal junction cancer that has not been treated before.
What could go wrong
This is an early-phase trial with only 72 participants, so results may not apply to everyone. Side effects from combining multiple cancer drugs could be significant, and the treatment may not shrink tumors as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric cancer gastric neoplasm gastroesophageal cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC CANCER GASTROESOPHAGEAL JUNCTION CANCER

Contacts and locations

Locations

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Chiba University Hospital

    Chiba, Chiba, 260-8677, Japan

  • Dokkyo Medical University Hospital

    Shimotsuga-gun, Tochigi, 321-0293, Japan

  • Fujita Health University Hospital

    Toyoake-shi, Aichi-ken, 470-1192, Japan

  • Fukui Prefectural Hospital

    Fukui-shi, Fukui, 910-8526, Japan

  • Fukushima Medical University Hospital

    Fukushima, Fukushima, 960-1295, Japan

  • Gifu University Hospital

    Gifu, Gifu, 501-1194, Japan

  • Gunma Prefectural Cancer Center

    Ota-shi, Gunma, 373-8550, Japan

  • Gunma University Hospital

    Maebashi, Gunma, 371-8511, Japan

  • Hirosaki University Hospital

    Hirosaki-shi, Aomori, 036-8563, Japan

  • Hiroshima City Hiroshima Citizens Hospital

    Hiroshima, Hiroshima, 730-8518, Japan

  • Hiroshima University Hospital

    Hiroshima, Hiroshima, 734-8551, Japan

  • IMSUT Hospital, The Institute of Medical Science The University of Tokyo

    Minato-ku, Tokyo, 108-8639, Japan

  • Ibaraki Prefectural Central Hospital

    Kasama-shi, Ibaraki, 309-1793, Japan

  • Ishikawa Prefectural Central Hospital

    Kanazawa, Ishikawa-ken, 920-8530, Japan

  • Kagawa University Hospital

    Kita-gun, Kagawa-ken, 761-0793, Japan

  • Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center

    Yokohama, Kanagawa, 241-8515, Japan

  • Kochi Health Sciences Center

    Kochi, Kochi, 781-8555, Japan

  • Korea University Guro Hospital

    Seoul, 08308, South Korea

  • Kyoto University Hospital

    Kyoto, Kyoto, 606-8507, Japan

  • Kyushu University Hospital

    Fukuoka, Fukuoka, 812-8582, Japan

  • National Cancer Center

    Goyang-si Gyeonggi-do, 10408, South Korea

  • National Cancer Center Hospital

    Chuo-ku, Tokyo, 104-0045, Japan

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, Ehime, 791-0280, Japan

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • National University Hospital

    Singapore, 119074, Singapore

  • Northport Veterans Affairs Medical Center

    Northport, New York, 11768, United States

  • Ogaki Municipal Hospital

    Ogaki-shi, Gifu, 503-8502, Japan

  • Okayama University Hospital

    Okayama, Okayama-ken, 700-8558, Japan

  • Osaka General Medical Center

    Osaka, Osaka, 558-8558, Japan

  • Osaka Medical and Pharmaceutical University Hospital

    Takatsuki-shi, Osaka, 569-8686, Japan

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, 03722, South Korea

  • Shizuoka Cancer Center

    Sunto-gun, Shizuoka, 411-8777, Japan

  • Shizuoka General Hospital

    Shizuoka, Shizuoka, 420-8527, Japan

  • St Marianna University Hospital

    Kawasaki-shi, Kanagawa, 216-8511, Japan

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • The Cancer Institute Hospital of Japanese Foundation for Cancer Research

    Koto-ku, Tokyo, 135-8550, Japan

  • Tohoku University Hospital

    Sendai, Miyagi, 980-8574, Japan

  • Toyama University Hospital

    Toyama, Toyama, 930-0194, Japan

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