Experimental drug acapatamab targets Hard-to-Treat prostate cancer

NCT ID NCT03792841

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 23 times

Summary

This early-stage study tested a new drug called acapatamab in 212 men with metastatic castration-resistant prostate cancer that had stopped responding to standard therapies. The drug works by directing the body's immune cells to attack cancer cells. The main goals were to check safety and find the best dose. The study was terminated early, so results are limited.

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Contacts and locations

Locations

  • BC Cancer Vancouver

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Chris OBrien Lifehouse

    Camperdown, New South Wales, 2050, Australia

  • City of Hope National Medical Center

    Duarte, California, 91010, United States

  • City of Hope at Long Beach Elm

    Long Beach, California, 90813, United States

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89169, United States

  • El Camino Hospital

    Campbell, California, 95008, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Erasmus Medisch Centrum

    Rotterdam, 3015 GD, Netherlands

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Krankenhaus der Barmherzigen Brueder Wien

    Vienna, 1020, Austria

  • Landeskrankenhaus Salzburg

    Salzburg, 5020, Austria

  • Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation

    Taoyuan, 33305, Taiwan

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • National Cancer Center Hospital East

    Kashiwa-shi, Chiba, 277-8577, Japan

  • National Cancer Centre Singapore

    Singapore, 169610, Singapore

  • National University Hospital

    Singapore, 119074, Singapore

  • Ordensklinikum Linz Elisabethinen

    Linz, 4020, Austria

  • Peter MacCallum Cancer Centre

    Parkville, Victoria, 3050, Australia

  • Scientia Clinical Research Ltd

    Randwick, New South Wales, 2031, Australia

  • Tulane Medical Center

    New Orleans, Louisiana, 70112, United States

  • Universitaetsklinikum Allgemeines Krankenhaus Wien

    Vienna, 1090, Austria

  • Universitair Ziekenhuis Gent

    Ghent, 9000, Belgium

  • Universite Catholique de Louvain Cliniques Universitaires Saint Luc

    Brussels, 1200, Belgium

  • University of California Los Angeles

    Los Angeles, California, 90095, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • Washington University

    St Louis, Missouri, 63110, United States

  • Weill Cornell Medical College

    New York, New York, 10065, United States

  • Yokohama City University Medical Center

    Yokohama, Kanagawa, 232-0024, Japan

Conditions

Explore the condition pages connected to this study.