Amgen

This study aims to monitor the long-term safety of a drug called romosozumab in children and adolescents with osteogenesis imperfecta (brittle bone disease). It follows 71 young people who completed a previous treatment trial to check for any delayed side effects. The main goal i…

This study aims to understand how a drug called inebilizumab works in children with Immunoglobulin G4-related Disease (IgG4-RD), a rare condition where the immune system attacks the body's own tissues. It will enroll about 15 children aged 2 to 18 to measure the drug's levels in …

This study is testing whether the drug AMG 732 can help people with thyroid eye disease whose eye bulging didn't improve or returned after previous treatment. The trial includes 30 adults who participated in an earlier AMG 732 study but didn't respond well or had their symptoms c…

This study is testing whether a drug called olpasiran can reduce the amount of soft, dangerous plaque in the heart arteries of people who already have heart disease and high levels of a specific blood fat called lipoprotein(a). About 406 participants will receive either olpasiran…

This study is testing whether giving a leukemia drug called blinatumomab as a simple injection under the skin works as well as giving it through a continuous IV drip. It will involve 560 adults newly diagnosed with a specific type of acute lymphoblastic leukemia who are already i…