Amgen

This study tests a drug called inebilizumab in 15 children (ages 2 to under 18) with IgG4-related disease, a rare condition where the immune system attacks the body. The main goals are to see how the drug moves through the body, how safe it is, and if it helps control the disease…

This study tests a drug called AMG 732 in people with thyroid eye disease who did not respond to treatment or whose symptoms returned after a previous study. About 30 adults will receive the drug to see if it reduces eye bulging. The goal is to find a better option for those who …

This study tests if a shot (subcutaneous injection) of the drug blinatumomab works as well as the standard IV drip for adults with a certain type of leukemia (Ph-negative B-ALL). About 560 newly diagnosed adults who are in remission after initial chemo will take part. The main go…

This study tests whether switching from popular weight-loss drugs (GLP-1 receptor agonists) to a new medication called maridebart cafraglutide can help adults with obesity or overweight maintain weight loss. About 300 participants who have already lost at least 10% of their body …

This early-stage study tests a new drug called xaluritamig in 40 adults with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The main goal is to check the drug's safety and how the body processes it. Participants must have cancer that has s…

This study tests how the body processes two different forms of the drug evolocumab in 400 healthy adults aged 18 to 60. Participants receive a single dose and are monitored for drug levels and side effects over about two months. The goal is to see if the forms are similar, not to…