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New drug shows promise for Long-Term ulcerative colitis control

NCT ID NCT05672199

Terminated Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a drug called efavaleukin alfa in people with moderate to severe ulcerative colitis who had already completed a previous study. The goal was to see if the drug is safe and works over a longer period, up to 104 weeks. The study was terminated early and enrolled only 25 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
efavaleukin alfa (AMG 592)
What this could lead to
If it works, this could provide a new long-term treatment option for people with moderate to severe ulcerative colitis.
What could go wrong
This is a small, early-phase extension study that was terminated, so results may be limited. The drug may not prove effective or safe over the long term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS

Contacts and locations

Locations

  • Centro de Investigaciones Medicas Mar del Plata

    Mar del Plata, Buenos Aires, B7600DHK, Argentina

  • Centrum Medyczne Melita Medical

    Wroclaw-Krzyki, 50-449, Poland

  • Cer Instituto Medico

    Quilmes, Buenos Aires, B1878DVB, Argentina

  • Clinexpert Kft

    Budapest, 1033, Hungary

  • Clinica Independencia

    Munro, Buenos Aires, 1605, Argentina

  • Clinica Medicum

    Bucharest, 012015, Romania

  • Clinica de Investigacion en Reumatologia y Obesidad SC

    Guadalajra, Jalisco, 44650, Mexico

  • Diagnostic-Consultative Center Convex EOOD

    Sofia, 1680, Bulgaria

  • Herlev Hospital

    Herlev, 2730, Denmark

  • Indian Health Service Health Research

    Kissimmee, Florida, 34741, United States

  • Intesto BE

    Bern, 3012, Switzerland

  • Kocaeli Universitesi Tip Fakultesi Hastanesi

    Kocaeli, 41001, Turkey (Türkiye)

  • MIND Klinika Kft

    Budapest, 1024, Hungary

  • Memorial Healthcare International SRL

    Bucharest, 013812, Romania

  • Mersin Universitesi Tip Fakultesi Hastanesi

    Mersin, 33343, Turkey (Türkiye)

  • NZOZ Twoje Zdrowie EL Spzoo

    Elblag, 82-300, Poland

  • Nagasaki University Hospital

    Nagasaki, Nagasaki, 852-8501, Japan

  • Ome Medical Center

    Ome-shi, Tokyo, 198-0042, Japan

  • Santa Maria Gastroenterology Medical Group

    Santa Maria, California, 93458, United States

  • Spitalul Clinic Colentina

    Bucharest, 020125, Romania

  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar

    Szeged, 6725, Hungary

  • Tsujinaka Hospital Kashiwanoha

    Kashiwa-shi, Chiba, 277-0871, Japan

  • Universitaetsklinikum Ulm

    Ulm, 89081, Germany

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • Wonju Severance Christian Hospital

    Wonju-si, Gangwon-do, 26426, South Korea

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