New drug shows promise for Long-Term ulcerative colitis control
NCT ID NCT05672199
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a drug called efavaleukin alfa in people with moderate to severe ulcerative colitis who had already completed a previous study. The goal was to see if the drug is safe and works over a longer period, up to 104 weeks. The study was terminated early and enrolled only 25 participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
efavaleukin alfa (AMG 592)
What this could lead to
If it works, this could provide a new long-term treatment option for people with moderate to severe ulcerative colitis.
What could go wrong
This is a small, early-phase extension study that was terminated, so results may be limited. The drug may not prove effective or safe over the long term.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Centro de Investigaciones Medicas Mar del Plata
Mar del Plata, Buenos Aires, B7600DHK, Argentina
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Centrum Medyczne Melita Medical
Wroclaw-Krzyki, 50-449, Poland
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Cer Instituto Medico
Quilmes, Buenos Aires, B1878DVB, Argentina
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Clinexpert Kft
Budapest, 1033, Hungary
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Clinica Independencia
Munro, Buenos Aires, 1605, Argentina
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Clinica Medicum
Bucharest, 012015, Romania
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Clinica de Investigacion en Reumatologia y Obesidad SC
Guadalajra, Jalisco, 44650, Mexico
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Diagnostic-Consultative Center Convex EOOD
Sofia, 1680, Bulgaria
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Herlev Hospital
Herlev, 2730, Denmark
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Indian Health Service Health Research
Kissimmee, Florida, 34741, United States
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Intesto BE
Bern, 3012, Switzerland
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Kocaeli Universitesi Tip Fakultesi Hastanesi
Kocaeli, 41001, Turkey (Türkiye)
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MIND Klinika Kft
Budapest, 1024, Hungary
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Memorial Healthcare International SRL
Bucharest, 013812, Romania
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Mersin Universitesi Tip Fakultesi Hastanesi
Mersin, 33343, Turkey (Türkiye)
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NZOZ Twoje Zdrowie EL Spzoo
Elblag, 82-300, Poland
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Nagasaki University Hospital
Nagasaki, Nagasaki, 852-8501, Japan
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Ome Medical Center
Ome-shi, Tokyo, 198-0042, Japan
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Santa Maria Gastroenterology Medical Group
Santa Maria, California, 93458, United States
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Spitalul Clinic Colentina
Bucharest, 020125, Romania
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Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar
Szeged, 6725, Hungary
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Tsujinaka Hospital Kashiwanoha
Kashiwa-shi, Chiba, 277-0871, Japan
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Universitaetsklinikum Ulm
Ulm, 89081, Germany
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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Wonju Severance Christian Hospital
Wonju-si, Gangwon-do, 26426, South Korea