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Experimental cancer drug AMG 199 tested in patients with stomach, colon, and pancreatic tumors

NCT ID NCT04117958

Terminated Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tested an experimental drug called AMG 199 in adults with advanced stomach, gastroesophageal junction, colorectal, or pancreatic cancers that have a specific protein (MUC17). The main goals were to check safety and find the best dose. The study was stopped early, so results are limited.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm gastric adenocarcinoma gastric neoplasm gastroesophageal junction adenocarcinoma pancreatic ductal adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MUC17-POSITIVE SOLID TUMORS

Contacts and locations

Locations

  • Aichi Cancer Center

    Nagoya, Aichi-ken, 464-8681, Japan

  • Amsterdam UMC - location VUmc

    Amsterdam, 1081 HV, Netherlands

  • Asan Medical Center

    Seoul, 138-736, South Korea

  • City of Hope National Medical Center

    Duarte, California, 91010, United States

  • Hospital Clinico Universitario de Valencia

    Valencia, Valencia, 46010, Spain

  • Hospital Universitari Vall d Hebron

    Barcelona, Catalonia, 08035, Spain

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Klinikum der Universitaet Muenchen Campus Grosshadern

    München, 81377, Germany

  • Klinikum rechts der Isar

    München, 81675, Germany

  • Landeskrankenhaus Salzburg

    Salzburg, 5020, Austria

  • Leids Universitair Medisch Centrum

    Leiden, 2333 ZA, Netherlands

  • National Cancer Center Hospital

    Chuo-ku, Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East

    Kashiwa-shi, Chiba, 277-8577, Japan

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, 03722, South Korea

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Universitaetsklinikum Hamburg Eppendorf Onkologisches Zentrum

    Hamburg, 20246, Germany

  • Universitaetsklinikum Leipzig

    Leipzig, 04103, Germany

  • University of California at Irvine Medical Center

    Orange, California, 92868, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.