New drug duo targets Hard-to-Treat cancers with missing gene
NCT ID NCT05975073
First seen Jan 05, 2026 · Last updated May 16, 2026 · Updated 23 times
Summary
This study tested two experimental drugs, anvumetostat and IDE397, in 53 adults with advanced solid tumors that lack a gene called MTAP. The goal was to find a safe dose and see if the combination can shrink tumors, especially in a type of lung cancer. The trial is complete, and results will help guide future treatment for these cancers.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Asan Medical Center
Seoul, 05505, South Korea
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Astera Cancer Care
East Brunswick, New Jersey, 08816, United States
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City of Hope National Medical Center
Duarte, California, 91090, United States
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Columbia University Irving Medical Center
New York, New York, 10032, United States
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Community Health Network MD Anderson Cancer Center - North
Indianapolis, Indiana, 46250, United States
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Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2, Canada
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University
Durham, North Carolina, 27710, United States
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Health Partners Cancer Center at Regions Hospital
Saint Paul, Minnesota, 55102, United States
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Hospital Universitari Vall d Hebron
Barcelona, Catalonia, 08035, Spain
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Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Monash Medical Centre
Clayton, Victoria, 3168, Australia
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National Cheng Kung University Hospital
Tainan, 70403, Taiwan
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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New York University Grossman School of Medicine and New York University Langone Hospitals
New York, New York, 10016, United States
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Next Oncology
Irving, Texas, 75039, United States
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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Prisma Health Upstate
Greenville, South Carolina, 29605, United States
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Rigshospitalet
Copenhagen, 2100, Denmark
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Sarah Cannon Research Institute
Denver, Colorado, 80218, United States
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Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital Yonsei University Health System
Seoul, 03722, South Korea
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The Queen Elizabeth Hospital
Woodville South, South Australia, 5011, Australia
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
Conditions
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