Kidney function may change how olpasiran works

NCT ID NCT05489614

Completed Knowledge-focused Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study looked at how a single dose of the drug olpasiran moves through the body in people with normal kidneys and those with various levels of kidney impairment. Thirty-three adults received one shot under the skin. The main goal was to measure drug levels in the blood and check safety, not to treat any condition. Results will help guide future dosing for patients with kidney disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Olpasiran (a drug given as a shot under the skin)
What this could lead to: If successful, this study could help doctors decide the right dose of olpasiran for patients with kidney problems.
What could go wrong: This was a very early, small study (33 people) focused on drug levels, not on treating disease. It does not prove olpasiran works or is safe for long-term use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for RENAL IMPAIRMENT are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

impaired renal function disease kidney failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL IMPAIRMENT

Contacts and locations

Locations

Advanced Pharma CR, LLC

Miami, Florida, 33147-4040, United States
CRSCA HC LLC, dba Creekside Post Acute

Yucaipa, California, 92399, United States
Clinical Pharmacology Of Miami, LLC

Miami, Florida, 33014, United States
Inland Empire Clinical Trials, LLC

Rialto, California, 92377-4697, United States
Nucleus Network - Minneapolis

Saint Paul, Minnesota, 55114, United States
Orlando Clinical Research Center

Orlando, Florida, 32809, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.