Kidney function may change how olpasiran works
NCT ID NCT05489614
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study looked at how a single dose of the drug olpasiran moves through the body in people with normal kidneys and those with various levels of kidney impairment. Thirty-three adults received one shot under the skin. The main goal was to measure drug levels in the blood and check safety, not to treat any condition. Results will help guide future dosing for patients with kidney disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Olpasiran (a drug given as a shot under the skin)
What this could lead to
If successful, this study could help doctors decide the right dose of olpasiran for patients with kidney problems.
What could go wrong
This was a very early, small study (33 people) focused on drug levels, not on treating disease. It does not prove olpasiran works or is safe for long-term use.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advanced Pharma CR, LLC
Miami, Florida, 33147-4040, United States
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CRSCA HC LLC, dba Creekside Post Acute
Yucaipa, California, 92399, United States
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Clinical Pharmacology Of Miami, LLC
Miami, Florida, 33014, United States
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Inland Empire Clinical Trials, LLC
Rialto, California, 92377-4697, United States
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Nucleus Network - Minneapolis
Saint Paul, Minnesota, 55114, United States
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Orlando Clinical Research Center
Orlando, Florida, 32809, United States