Can kidney health change how a new drug works?

NCT ID NCT07741604

Not yet recruiting Knowledge-focused Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study looks at how different levels of kidney function affect the way the body handles an experimental drug called RO7795081. Researchers will give a single oral dose to people with various degrees of kidney impairment and compare them to people with normal kidney function. The goal is to see if kidney problems change drug levels in the blood and whether the drug is safe. This information could help guide future dosing recommendations for people with kidney disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RO7795081 (also known as CT-996), an experimental drug given as a single oral dose
What this could lead to: If successful, this study could help determine the right dosing of RO7795081 for people with kidney problems, potentially making future treatments safer and more effective for them.
What could go wrong: This is an early-phase study with a small number of participants, so results may not apply to everyone. The drug may have side effects, and the study may not lead to a treatment.

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Conditions

The condition(s) this trial relates to.

kidney failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL IMPAIRMENT

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