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New combo therapy shows promise for tough lung cancer

NCT ID NCT04885998

Completed Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tested a combination of two drugs, tarlatamab and AMG 404, in 23 adults with small cell lung cancer that had worsened after standard chemotherapy. The main goal was to check safety and find the right dose for future studies. Participants had to be in fairly good health (ECOG 0-1) and could have treated brain metastases.

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Conditions

The condition(s) this trial relates to.

lung neoplasm small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMALL CELL LUNG CANCER

Contacts and locations

Locations

  • Chung Shan Medical University Hospital

    Taichung, 40201, Taiwan

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Medizinische Universitaet Innsbruck

    Innsbruck, 6020, Austria

  • National Cancer Center Hospital

    Chuo-ku, Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East

    Kashiwa-shi, Chiba, 277-8577, Japan

  • National Cancer Centre Singapore

    Singapore, 169610, Singapore

  • National University Hospital

    Singapore, 119074, Singapore

  • Northwestern University, Robert H Lurie Comprehensive Cancer Center

    Chicago, Illinois, 60611, United States

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37203, United States

  • Universitaetsklinikum Allgemeines Krankenhaus Wien

    Vienna, 1090, Austria

  • Universitair Ziekenhuis Antwerpen

    Edegem, 2650, Belgium

  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg

    Leuven, 3000, Belgium

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Kentucky

    Lexington, Kentucky, 40536, United States

  • Wake Forest Baptist Comprehensive Cancer Research Center

    Winston-Salem, North Carolina, 27157, United States

More trials for these conditions

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