New combo therapy targets tough lung cancer
NCT ID NCT06898957
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a combination of three drugs—tarlatamab, YL201, and durvalumab—in 29 adults with extensive stage small cell lung cancer that has progressed after prior treatment. The main goal is to check safety and side effects, while also measuring how well the tumors respond. It's a small, early study, so results will guide future research rather than offer a new treatment right away.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tarlatamab, YL201, and Durvalumab (anti-PD-L1)
What this could lead to
If successful, this could point toward a new combination treatment option for people with advanced small cell lung cancer.
What could go wrong
This is a very early, small phase 1b study focused on safety, not proof of effectiveness. The combination may cause serious side effects or fail to shrink tumors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alexandra Hospital
Athens, 11528, Greece
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Asan Medical Center
Seoul, 05505, South Korea
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Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, 20162, Italy
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CHU de Quebec Hopital de l Enfant Jesus
Québec, Quebec, G1J 1Z4, Canada
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Centre Leon Berard
Lyon, 69373, France
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City of Hope Orange County Lennar Foundation Cancer Center
Irvine, California, 92618, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Clinexpert Kft Bugat Pal Korhaz
Gyöngyös, 3200, Hungary
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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European Interbalkan Medical Center
Thessaloniki, 57001, Greece
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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Fujian Cancer Hospital
Fuzhou, 350011, China
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Gustave Roussy
Villejuif, 94805, France
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Henry Dunant Hospital Center
Athens, 11526, Greece
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Hospital Universitari Vall d Hebron
Barcelona, Catalonia, 08035, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Madrid, 28222, Spain
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Hospital de la Santa Creu i Sant Pau
Barcelona, Catalonia, 08041, Spain
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Iatriko Diavalkaniko Thessalonikis
Thessaloniki, 57001, Greece
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Institut Bergonie
Bordeaux, 33000, France
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Institut Universitaire du Cancer Toulouse Oncopole
Toulouse, 31059, France
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Istituto Romagnolo per lo Studio dei Tumori Dino Amadori
Meldola (FC), 47014, Italy
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Istituto di Candiolo Fondazione del Piemonte per l Oncologia IRCCS
Candiolo to, 10060, Italy
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Sanford Oncology Clinic and Pharmacy
Sioux Falls, South Dakota, 54104, United States
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Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122, United States
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Semmelweis Egyetem
Budapest, 1083, Hungary
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital Yonsei University Health System
Seoul, 03722, South Korea
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Shandong Cancer Hospital
Jinan, Shandong, 250117, China
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Siteman Cancer Center
St Louis, Missouri, 63110, United States
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Swedish Medical Center
Seattle, Washington, 98104, United States
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Universitaetsklinikum Essen
Essen, 45147, Germany
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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West China Hospital of Sichuan University
Chengdu, Sichuan, 611135, China
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Yale New Haven Hospital
New Haven, Connecticut, 06510, United States