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New hope for kids with rare blood vessel disease: avacopan trial launches

NCT ID NCT06321601

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether the drug avacopan can help children aged 6 to 18 with a rare autoimmune disease called ANCA-associated vasculitis, which causes inflammation of blood vessels. About 20 participants will receive avacopan alongside standard treatments like rituximab or cyclophosphamide. The main goal is to see if the disease goes into remission by 26 weeks and stays under control for a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

avacopan (a drug that blocks inflammation, taken by mouth)

What this could lead to

If successful, this could provide a new treatment option for children with this rare autoimmune disease, potentially reducing the need for steroids.

What could go wrong

This is a small, single-arm study with no placebo group, so results may be less reliable. Avacopan may cause side effects like infections or liver issues.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

granulomatosis with polyangiitis microscopic polyangiitis vasculitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VASCULITIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Akron Childrens Hospital

    RECRUITING

    Akron, Ohio, 44308, United States

  • Alberta Childrens Hospital

    RECRUITING

    Calgary, Alberta, T3B 6A8, Canada

  • British Columbia Childrens Hospital

    RECRUITING

    Vancouver, British Columbia, V6H 3N1, Canada

  • CHU Sainte Justine

    RECRUITING

    Montreal, Quebec, H3T 1C5, Canada

  • Centre Hospitalier Universitaire de Bordeaux - Hopital Pellegrin

    RECRUITING

    Bordeaux, 33076, France

  • Cleveland Clinic Foundation

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Cohen Children Medical Center

    RECRUITING

    Lake Success, New York, 11042, United States

  • Dzieciecy Szpital Kliniczny im. Jozefa Polikarpa Brudzinskiego w Warszawie

    RECRUITING

    Warsaw, 02-091, Poland

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Erciyes Universitesi Tip Fakultesi Hastanesi

    RECRUITING

    Kayseri, 38030, Turkey (Türkiye)

  • Fakultni nemocnice v Motole

    RECRUITING

    Prague, 150 06, Czechia

  • Hacettepe Universitesi Tip Fakultesi Hastanesi

    RECRUITING

    Ankara, 06100, Turkey (Türkiye)

  • Hopital Necker

    RECRUITING

    Paris, 75015, France

  • Hopital Necker Enfants Malades

    RECRUITING

    Paris, 75015, France

  • Hospices Civils de Lyon Hopital Femme Mere Enfant

    RECRUITING

    Bron, 69677, France

  • Hospital Sant Joan de Deu

    RECRUITING

    Esplugues de Llobregat, Catalonia, 08950, Spain

  • Hospital Universitari Vall d Hebron

    RECRUITING

    Barcelona, Catalonia, 08035, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Narodny ustav detskych chorob

    RECRUITING

    Bratislava, 833 40, Slovakia

  • Riley Hospital for Children

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Semmelweis Egyetem

    RECRUITING

    Budapest, 1094, Hungary

  • Stollery Childrens Hospital

    RECRUITING

    Edmonton, Alberta, T6G 1C9, Canada

  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar

    TERMINATED

    Szeged, 6720, Hungary

  • Texas Childrens Hospital

    RECRUITING

    Houston, Texas, 77030, United States

  • Umraniye Egitim ve Arastirma Hastanesi

    RECRUITING

    Istanbul, 34764, Turkey (Türkiye)

  • Universitair Ziekenhuis Gent

    RECRUITING

    Ghent, 9000, Belgium

  • Universitair Ziekenhuis Leuven - Gasthuisberg

    RECRUITING

    Leuven, 3000, Belgium

  • University of Minnesota Masonic Childrens Hospital Discovery Clinic

    RECRUITING

    Minneapolis, Minnesota, 55454, United States

  • University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

  • University of Pittsburgh Medical Center Childrens Hospital of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

  • Uniwersytecki Szpital Dzieciecy w Krakowie

    RECRUITING

    Krakow, 30-663, Poland

  • Uniwersyteckie Centrum Kliniczne

    RECRUITING

    Gdansk, 80-952, Poland

  • Vseobecna fakultni nemocnice v Praze

    RECRUITING

    Prague, 128 08, Czechia

  • Wake Forest University Health Sciences

    RECRUITING

    Charlotte, North Carolina, 28203, United States