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New shot helps diabetics shed pounds in major trial

NCT ID NCT06858878

Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new medication, maridebart cafraglutide, to see if it helps adults with type 2 diabetes who are overweight or obese lose more weight than a placebo. About 1,100 participants will receive either the drug or a placebo for 72 weeks. The main goal is to measure the percentage of body weight lost.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

1,105 people

The number who actually took part.

Started

Mar 2025

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years. * Body mass index ≥ 27 kg/m\^2. * History of at least 1 self-reported unsuccessful attempt at weight loss by diet and exercise. * Diagnosis of T2DM. Exclusion Criteria: * Type 1 diabetes mellitus. * Self-reported change in body weight \> 5 kg within 90 days before screening. * Proliferative diabetic retinopathy OR diabetic macular edema OR non-proliferative diabetic retinopathy that requires acute treatment. * Obesity induced by other endocrinologic disorders. * Family (first-degree relative\[s\]) or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2. * History of chronic pancreatitis or history of acute pancreatitis within 180 days before screening. * History of unstable major depressive disorder (MDD) or other severe psychiatric disorder within 2 years before screening. * Lifetime history of suicide attempt.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Type 2 diabetes mellitus (T2DM), obesity, overweight

Contacts and locations

Locations

  • Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD

    Sofia, 1407, Bulgaria

  • Advanced Internal Medicine

    Paducah, Kentucky, 42001, United States

  • Aggarwal and Associates Ltd

    Brampton, Ontario, L6T 0G1, Canada

  • Aintree University Hospital

    Liverpool, L9 7AL, United Kingdom

  • Albany Medical College

    Albany, New York, 12203, United States

  • Albion Finch Medical Centre

    Toronto, Ontario, M9V 4B4, Canada

  • Alliance For Multispecialty Research - Oak Brook

    Oak Brook, Illinois, 60523, United States

  • Alliance for Multispecialty Research - Kansas City

    Kansas City, Missouri, 64114, United States

  • Alliance for Multispecialty Research - Layton

    Layton, Utah, 84041, United States

  • Alliance for Multispecialty Research LLC

    Wichita, Kansas, 67207, United States

  • Alliance for Multispecialty Research Mobile

    Mobile, Alabama, 36608, United States

  • Alliance for Multispecialty Research Newton

    Newton, Kansas, 67114, United States

  • Alliance for Multispecialty Research, LLC - Park Ridge

    Park Ridge, Illinois, 66068, United States

  • AmBeNet GmbH

    Leipzig, 04107, Germany

  • Ambulatory for specialized outpatient medical aid in endocrinology-Dr Albena Dinkova EOOD

    Pleven, 5801, Bulgaria

  • Annapolis Internal Medicine, LLC

    Annapolis, Maryland, 21401, United States

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Asheville Clinical Research

    Asheville, North Carolina, 28803, United States

  • Avacare Foothills Research Center

    Phoenix, Arizona, 85044, United States

  • Azienda Ospedaliero Universitaria Careggi

    Florence, 50134, Italy

  • Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco

    Milan, 20157, Italy

  • Bluewater Clinical Research Group Incorporated

    Sarnia, Ontario, N7T 4X3, Canada

  • Borbanya Praxis Egeszsegugyi Kft

    Nyíregyháza, 4405, Hungary

  • Borvo Clinic Kft

    Debrecen, 4025, Hungary

  • Brigham and Womens Hospital

    Boston, Massachusetts, 02115, United States

  • CCR Ostrava sro

    Ostrava, 702 00, Czechia

  • Carteret Medical Group

    Morehead City, North Carolina, 28557, United States

  • Cedar Health Research, LLC

    Dallas, Texas, 75251, United States

  • Cedar Health Research, LLC

    Euless, Texas, 76040, United States

  • Cedic Centro de Investigacion Clinica

    CABA, Buenos Aires, C1060ABN, Argentina

  • Cemedic Centro de Especialidades Medicas

    CABA, Buenos Aires, C1407GTN, Argentina

  • Centre Medical Acadie

    Montreal, Quebec, H4N 2W2, Canada

  • Centricity Research Brampton

    Brampton, Ontario, L6S 0C6, Canada

  • Centricity Research Ottawa LMC

    Nepean, Ontario, K2J 0V2, Canada

  • Centricity Research Pointe-Claire

    Pointe-Claire, Quebec, H9R 4S3, Canada

  • Centricity Research Quebec City

    Lévis, Quebec, G6W 0M5, Canada

  • Centricity Research Vaughan

    Concord, Ontario, L4K 4M2, Canada

  • Centro Medico Viamonte

    CABA, Buenos Aires, 1120, Argentina

  • Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna

    Lodz, 90-338, Poland

  • Centrum für Diagnostik und Gesundheit

    München, 80809, Germany

  • Charite - Universitaetsmedizin Berlin, Campus Mitte

    Berlin, 10117, Germany

  • Chronic Disease Innovation Centre

    Winnipeg, Manitoba, R2V 3M3, Canada

  • Cinme - Centro de Investigaciones Metabolicas

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1056ABI, Argentina

  • Ciprec Centro de Investigacion y Prevencion Cardiovascular

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1061AAT, Argentina

  • Clifton Medical Centre

    Rotherham, S65 1DA, United Kingdom

  • ClinDiab Kft

    Budapest, 1089, Hungary

  • Clinexpert Kft

    Budapest, 1033, Hungary

  • Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski

    Lublin, 20-011, Poland

  • Conquest Research - Winter Park

    Winter Park, Florida, 32789, United States

  • Consultorios Medicos Dr Besada

    CABA, Buenos Aires, C1426ABP, Argentina

  • Core Healthcare Group

    Cerritos, California, 90703, United States

  • DRC Gyogyszervizsgalo Kozpont Kft

    Balatonfüred, 8230, Hungary

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032, Hungary

  • Desert Clinical Research

    Mesa, Arizona, 85213, United States

  • Diabetespraxis Bad Mergentheim

    Bad Mergentheim, 97980, Germany

  • Diabetespraxis Dr. Hermann Braun

    Berlin, 13187, Germany

  • Diabeteszentrum Hamburg West

    Hamburg, 22607, Germany

  • Diabetologische Schwerpunktpraxis Hohenmoelsen

    Hohenmölsen, 06679, Germany

  • Diagnostic - Consultative Center XX - Sofia EOOD

    Sofia, 1404, Bulgaria

  • Diahelp sro

    Pardubice, 530 02, Czechia

  • Diex Recherche Trois Rivieres

    Trois-Rivières, Quebec, G9A 4P3, Canada

  • Ekamed Spolka z Ograniczona Odpowiedzialnoscia

    Lublin, 20-718, Poland

  • Elligo Clinical Research Center

    Austin, Texas, 78701, United States

  • Empire Clinical Research

    Pomona, California, 91767, United States

  • Encore Medical Research of Weston LLC

    Weston, Florida, 33331, United States

  • Endeavor Health Medical Group - Endocrinology and Diabetes- Skokie

    Skokie, Illinois, 60077, United States

  • Endokrinologie Cerny Most sro

    Prague, 198 00, Czechia

  • Endokrinologikum Hamburg

    Hamburg, 22767, Germany

  • Fakultni nemocnice Brno

    Brno, 625 00, Czechia

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, 100 34, Czechia

  • Florida Institute for Clinical Research

    Orlando, Florida, 32825, United States

  • Flourish Research

    Northridge, California, 91325, United States

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • FutureMeds Birmingham

    Birmingham, B21 9RY, United Kingdom

  • FutureMeds Glasgow

    Glasgow, G20 7BE, United Kingdom

  • Gilbert Center for Family Medicine

    Gilbert, Arizona, 85296, United States

  • Greenwich Clinical Trials

    Riverside, Connecticut, 06878, United States

  • Hallym University Kangnam Sacred Heart Hospital

    Seoul, 07441, South Korea

  • Headlands Research California

    Escondido, California, 92025, United States

  • Hull Royal Infirmary

    Hull, HU3 2JZ, United Kingdom

  • IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola

    Bologna, 40138, Italy

  • IRCCS Centro Cardiologico Monzino

    Milan, 20138, Italy

  • Ima Clinical Research - West Virginia

    Morgantown, West Virginia, 26505, United States

  • Ima Clinical Research- Monroe

    Monroe, Louisiana, 71201, United States

  • Indago Research and Health Center

    Hialeah, Florida, 33012, United States

  • Indiana Medical Research Institute

    Merrillville, Indiana, 46410, United States

  • Infinity Clinical Trials

    San Diego, California, 92108, United States

  • InnoDiab Forschung

    Essen, 45136, Germany

  • Institut de recherches cliniques de Montreal

    Montreal, Quebec, H2W 1R7, Canada

  • Institut klinicke a experimentalni mediciny

    Prague, 140 21, Czechia

  • International Diabetes Center - HealthPartners Institute

    Minneapolis, Minnesota, 55416, United States

  • Iowa Diabetes Research

    West Des Moines, Iowa, 50266, United States

  • Juno Research LLC

    Houston, Texas, 77040, United States

  • Juno Research LLC

    Houston, Texas, 77054, United States

  • Kangbuk Samsung Hospital

    Seoul, 03181, South Korea

  • Kardiologische Praxis Doktor Jens Taggeselle

    Markkleeberg, 04416, Germany

  • Komaromi Selye Janos Korhaz

    Komárom, 2900, Hungary

  • Korea University Anam Hospital

    Seoul, 02841, South Korea

  • Korea University Ansan Hospital

    Ansan-si, Gyeonggi-do, 15355, South Korea

  • KyungHee University Gangdong Hospital

    Seoul, 05278, South Korea

  • Latin Clinical Trial Center

    San Juan, 00909, Puerto Rico

  • Lausmed Kft

    Baja, 6500, Hungary

  • Layton Medical Centre

    Blackpool, FY3 7EN, United Kingdom

  • MED-TIMA Kft

    Budapest, 1132, Hungary

  • Maffei Centro Medico

    CABA, Buenos Aires, C1425AGC, Argentina

  • Manassas Clinical Research Center Inc

    Manassas, Virginia, 20110, United States

  • Mazda Hospital of Mazda Motor Corporation

    Aki-gun, Hiroshima, 735-8585, Japan

  • Medical Care LLC

    Elizabethton, Tennessee, 37643, United States

  • Medical Center Berbatov EOOD

    Yambol, 8600, Bulgaria

  • Medical Corporation Ouitsukai Kanno Naika

    Mitaka-shi, Tokyo, 181-0013, Japan

  • Medicome Spolka z Ograniczona Odpowiedzialnoscia

    Oświęcim, 32-600, Poland

  • Mikannohana Clinic, Diabetes, Endocrinology and Metabolism

    Matsuyama, Ehime, 790-0034, Japan

  • Milan Kvapil sro

    Prague, 149 00, Czechia

  • Milan Kvapil sro

    Pribram VIII, 261 01, Czechia

  • Milestone Research

    London, Ontario, N5W 6A2, Canada

  • Morinaga Ueno Clinic

    Kumamoto, Kumamoto, 860-0863, Japan

  • Morizono Medical Clinic

    Kitakyusyu-shi, Fukuoka, 807-0072, Japan

  • Mvz am Bahnhof Spandau

    Berlin, 13597, Germany

  • NIHR Leicestershire & Northamptonshire Commercial Research Delivery Centre

    Leicester, LE5 4PW, United Kingdom

  • NZOZ Przychodnia Specjalistyczna A Wittek H Rudzki spolka jawna

    Ruda Śląska, 41-709, Poland

  • Nakakinen Clinic

    Naka, Ibaraki, 311-0113, Japan

  • Nakamoto Medical Clinic

    Mito, Ibaraki, 310-0826, Japan

  • Nbr Polska Tomasz Klodawski

    Warsaw, 00-710, Poland

  • New Horizon Research Center

    Miami, Florida, 33165, United States

  • North York Diagnostic and Cardiac Centre

    North York, Ontario, M6B 3H7, Canada

  • Northeast Clinical Research of San Antonio LLC

    San Antonio, Texas, 78233, United States

  • Nova Scotia Health Authority, Queen Elizabeth ii Health Sciences Centre

    Halifax, Nova Scotia, B3H 2Y9, Canada

  • Obudai Egeszsegugyi Centrum Kft

    Budapest, 1036, Hungary

  • Ohishi Naika Clinic

    Tsuchiura-shi, Ibaraki, 300-0835, Japan

  • Optimus U Corporation

    Miami, Florida, 33135, United States

  • Ormeau Clinical Trials Ltd

    Belfast, BT28BG, United Kingdom

  • Ospedale Civico, Di Cristina e Benfratelli

    Palermo, 90127, Italy

  • Osvaldo A Brusco MD PA

    Corpus Christi, Texas, 78414, United States

  • Palm Research Center Inc

    Las Vegas, Nevada, 89128, United States

  • Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji

    Warsaw, 02-507, Poland

  • Paradigm Clinical Research

    Modesto, California, 95355, United States

  • Physicians East

    Greenville, North Carolina, 27834, United States

  • Pratia Pardubice as

    Pardubice, 530 02, Czechia

  • Premier Clinical Trial Network

    Hamilton, Ontario, L8L 5G4, Canada

  • Premier Research

    Trenton, New Jersey, 08611, United States

  • Prevencia-2000-Medical center for outpatient medical aid OOD

    Stara Zagora, 6000, Bulgaria

  • Red-Institut GmbH

    Oldenburg, 23758, Germany

  • Restrial sro

    Prague, 181 00, Czechia

  • Salvia-Lekston i Madej Spolka Jawna

    Katowice, 40-772, Poland

  • San Fernando Valley Health Institute

    Canoga Park, California, 91304, United States

  • San Marcus Research Clinic Inc

    Miami Lakes, Florida, 33014, United States

  • Schwerpunktpraxis fuer Diabetes, Gefaess- & Ernaehrungsmedizin

    Falkensee, 14612, Germany

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, 03722, South Korea

  • Shiraiwa Medical Clinic

    Kashiwara-shi, Osaka, 582-0005, Japan

  • Soma Clinical Trials, LLC

    Denison, Texas, 75020, United States

  • Southmead Hospital

    Bristol, BS10 5NB, United Kingdom

  • Staploe Medical Centre

    Ely, CB7 5JD, United Kingdom

  • Suruga Clinic

    Shizuoka, Shizuoka, 424-0855, Japan

  • Tekton Research

    McKinney, Texas, 75069, United States

  • The Catholic University of Korea Seoul St Marys Hospital

    Seoul, 06591, South Korea

  • Tomasz Blicharski Lubelskie Centrum Diagnostyczne

    Świdnik, 21-040, Poland

  • Universita degli Studi Gabriele D Annunzio di Chieti e Pescara

    Chieti, 66100, Italy

  • Universitaets-Herzzentrum Freiburg - Bad Krozingen

    Bad Krozingen, 79189, Germany

  • Universitaetsklinikum Leipzig

    Leipzig, 04103, Germany

  • Universitaetsklinikum der Ruhr-Universitaet Bochum

    Bad Oeynhausen, 32545, Germany

  • Universitatsklinikum Aachen

    Aachen, 52074, Germany

  • University Multiprofile Hospital for Active Treatment Sofiamed OOD

    Sofia, 1750, Bulgaria

  • University of California Irvine

    Orange, California, 92868, United States

  • VA Puget Sound Healthcare System

    Seattle, Washington, 98108, United States

  • Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz

    Szombathely, 9700, Hungary

  • Vector Clinical Trials

    Sparks, Nevada, 89436, United States

  • Velocity Clinical Research - Cincinnati

    Blue Ash, Ohio, 45242, United States

  • Velocity Clinical Research - Providence

    East Greenwich, Rhode Island, 02818, United States

  • Velocity Clinical Research - Springdale

    Cincinnati, Ohio, 45246, United States

  • Velocity Clinical Research Chula Vista

    Chula Vista, California, 91911, United States

  • Velocity Clinical Research GmbH

    Berlin, 10787, Germany

  • Velocity Nova Sp zoo Velocity Pulawy

    Puławy, 24-100, Poland

  • Velocity Nova Sp zoo Velocity Staszow

    Staszów, 28-200, Poland

  • Vseobecna fakultni nemocnice v Praze

    Prague, 128 08, Czechia

  • Waterloo Medical Centre

    Blackpool, FY4 3AD, United Kingdom

  • West Clinical Research

    Morehead City, North Carolina, 28557, United States

  • Winterberry Family Medicine

    Hamilton, Ontario, L8J 0B6, Canada

  • Wromedica I Bielicka A Strzalkowska SC

    Wroclaw, 51-685, Poland

  • Yeungnam University Medical Center

    Daegu, 42415, South Korea

  • Yonsei University Wonju Severance Christian Hospital

    Wonju-si, Gangwon-do, 26426, South Korea

  • Your Research Network Inc.

    Niagara Falls, Ontario, L2H 1H5, Canada

  • Yutenji Medical Clinic

    Meguro-ku, Tokyo, 153-0053, Japan

  • Zentrum fuer Diabtes und Gefaesskrankheiten im Franziskus Carré Muenster

    Münster, 48145, Germany

  • Zentrum fuer Klinische Studien Suedbrandenburg GmbH

    Elsterwerda, 04910, Germany

  • tlc Diabetes and Endocrinology

    Surrey, British Columbia, V3T 2V6, Canada

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