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New drug AMG 732 aims to reduce eye bulging in thyroid eye disease

NCT ID NCT06401044

Ongoing Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 4 times

Summary

This study tests a new drug called AMG 732 for people with moderate-to-severe active thyroid eye disease, a condition that causes eye bulging and discomfort. The trial has two parts: Part A checks safety in healthy volunteers, and Part B tests how well the drug works in patients. Researchers will measure changes in eye protrusion and monitor for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
AMG 732 (an injectable drug)
What this could lead to
If it works, this could lead to a new treatment option that reduces eye bulging and other symptoms of thyroid eye disease.
What could go wrong
This is an early-phase trial with only 88 participants, so results may not apply to everyone. The drug may cause side effects or fail to show benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endocrine exophthalmos Graves Ophthalmopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THYROID EYE DISEASE

Contacts and locations

Locations

  • Aichi Medical University Hospital

    Nagakute-shi, Aichi-ken, 480-1195, Japan

  • Amy Patel Jain MD

    Newport Beach, California, 92660, United States

  • Applied Research Center of Arkansas

    Little Rock, Arkansas, 72205, United States

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56124, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56126, Italy

  • Azienda Socio Sanitaria Territoriale dei Sette Laghi

    Varese, 21100, Italy

  • Baylor College of Medicine Medical Center

    Houston, Texas, 77030, United States

  • Buergerhospital und Clementine Kinderhospital gGmbH

    Frankfurt am Main, 60318, Germany

  • CHU de Québec-Université Laval - CUO-Recherche Clinique, Hopital du Saint-Sacrement

    Québec, Quebec, G1S 4L8, Canada

  • Centre Hospitalier Universitaire de Nantes - Hopital Nord Laennec

    Nantes, 44800, France

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • Dc-Med Spolka z Ograniczona Odpowiedzialnoscia Spolka Komandytowa

    Swidnica, 58-100, Poland

  • Eb Group Spolka z ograniczona odpowiedzialnoscia

    Warsaw, 00-189, Poland

  • Erie Retina Research

    Erie, Pennsylvania, 16505, United States

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • General Hospital of Athens Laiko

    Athens, 11527, Greece

  • Hayashi Eye Hospital

    Fukuoka, Fukuoka, 812-0011, Japan

  • Hopital Pitie-Salpetriere

    Paris, 75013, France

  • Hospital Universitari i Politecnic La Fe

    Valencia, 46026, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Virgen Macarena

    Seville, Andalusia, 41009, Spain

  • Ilumina Medical Research

    Kissimmee, Florida, 34744, United States

  • Ippokratio General Hospital of Thessaloniki

    Thessaloniki, 54642, Greece

  • Kozawa Eye Hospital And Diabetes Center

    Mito, Ibaraki, 310-0845, Japan

  • Levenson Eye Associates

    Jacksonville, Florida, 32204, United States

  • Macquarie University

    North Ryde, New South Wales, 2109, Australia

  • Massachusetts Eye and Ear Infirmary

    Boston, Massachusetts, 02114, United States

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • National University Hospital

    Singapore, 119074, Singapore

  • North Shore Private Hospital

    St Leonards, New South Wales, 2065, Australia

  • Ppd Las Vegas Research Unit

    Las Vegas, Nevada, 89113, United States

  • Profesorskie Centrum Medyczne Spolka z Ograniczona Odpowiedzialnoscia

    Gdansk, 80-180, Poland

  • Santé Québec Est-de-l'Île-de-Montréal - Universitaire

    Montreal, Quebec, H1T 2M4, Canada

  • Sarasota Retina Institute

    Sarasota, Florida, 34239, United States

  • Singapore National Eye Centre

    Singapore, 169608, Singapore

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Universitaetsklinikum Essen

    Essen, 45147, Germany

  • Universitaetsklinikum Freiburg

    Freiburg im Breisgau, 79106, Germany

  • Universitaetsklinikum Leipzig AoeR

    Leipzig, 04013, Germany

  • University of Miyazaki Hospital

    Miyazaki, Miyazaki, 889-1692, Japan

  • Uniwersyteckie Centrum Stomatologii I Medycyny Specjalistycznej Spzoo

    Poznan, 60-354, Poland

  • Vancouver General Hospital

    Vancouver, British Columbia, V5Z 0A6, Canada

  • Vision Medical Research, Inc.

    Orland Park, Illinois, 60462, United States

  • West Virginia University

    Morgantown, West Virginia, 26506, United States

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