Can a targeted antibody calm thyroid eye disease?

NCT ID NCT05176639

Completed Disease control Sponsor: Viridian Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial tests whether veligrotug, an antibody that blocks a receptor involved in inflammation, can reduce eye bulging and swelling in people with active thyroid eye disease. Participants receive five infusions of the drug or a placebo. The study measures how many people see a meaningful reduction in eye protrusion, along with safety and tolerability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: veligrotug (VRDN-001), a humanized monoclonal antibody that blocks the insulin-like growth factor-1 receptor (IGF-1R) to reduce inflammation and tissue swelling in thyroid eye disease.
What this could lead to: If successful, veligrotug could offer a new treatment to reduce eye bulging and inflammation in people with active thyroid eye disease, potentially improving vision and appearance.
What could go wrong: This is a Phase 3 trial, but results are not yet known. The drug may not prove more effective than placebo, and there could be side effects from blocking IGF-1R.

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Conditions

The condition(s) this trial relates to.

endocrine exophthalmos Graves disease Graves Ophthalmopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THYROID EYE DISEASE

Contacts and locations

Locations

4 Wojskowy Szpital Kliniczny z Polikinika SP ZOZ

Wroclaw, 53-114, Poland
AP-HP- Hopital de la Pitie Salpetriere

Paris, 75013, France
Advanced Research International, LLC

Las Vegas, Nevada, 89144, United States
Amy Patel Jain, MD

Newport Beach, California, 92260, United States
Baylor College of Medicine (BCM)-Ophthalmology

Houston, Texas, 77030, United States
Byers Eye Institute/Stanford University

Palo Alto, California, 94303, United States
CH Nice

Nice, 06000, France
CHU d'Angers

Angers, 49100, France
Centre Hospitalier National D'ophtalmologie

Paris, 75012, France
Clinica Bonanova de Cirugia Ocular

Barcelona, 08022, Spain
Clinica Universidad de Navarra

Madrid, 28027, Spain
Clinica Universidad de Navarra

Pamplona, 31008, Spain
Complexo Hospiralario Universitario de Santiago-Hospital Medico-Ciruxico de Conxo

Santiago, 15706, Spain
Edward Jenner Research Group Center LLC

Plantation, Florida, 33317, United States
Fraser Eye Care Center

Fraser, Michigan, 48026, United States
Guy's and St. Thomas NHS Trust

London, United Kingdon, SE1 7EH, United Kingdom
Hospital Arruzafa

Córdoba, 14012, Spain
Hospital Universitario Miguel Servet, Servicio de Paseo Isabel La Catdlica1

Zaragoza, 50009, Spain
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitatio Virgen De La Macarena, Servicio de Oftalmologia

Seville, 41071, Spain
Johannes Gutenberg-University Medical Center

Mainz, 55131, Germany
KU Medical Center, University of Kansas

Kansas City, Kansas, 66103, United States
Kahana Oculoplastic & Orbital Surgery

Livonia, Michigan, 48152, United States
MACRO Trials, Inc.

Los Angeles, California, 90049, United States
Massachusetts Eye and Ear

Boston, Massachusetts, 02114, United States
Med-Care Research Inc.

Miami, Florida, 33125, United States
NZOZ E-Vita

Bialystok, 15-879, Poland
Neuro-Eye Clinical Trials

Houston, Texas, 77074, United States
Neuro-Ophthalmology of Texas PLLC

Houston, Texas, 77074, United States
New York Eye Ear Infirmary of Mount Sinai

New York, New York, 10003, United States
North Shore Eye Surgery

Sydney, 2065, Australia
Northwick Park Hospital

London, United Kingdon, HA13UJ, United Kingdom
Ophthalmic Consultants of Boston

Weymouth, Massachusetts, 02189, United States
Panstwowy Instytut Medycsny MSWiA

Warsaw, 02-507, Poland
Rutgers-New Jersey Medical School-Newark

Newark, New Jersey, 07103, United States
Santa Familia PTG Lodz

Lodz, 90-302, Poland
Sarasota Retina Institute

Sarasota, Florida, 34231, United States
Senta Clinic

San Diego, California, 95207, United States
Sina Medical Center

Homestead, Florida, 33034, United States
Specjakistyczny Osrodek Okulistyczny Oculomedica

Bydgoszcz, 85-870, Poland
Sydney Eye Hospital

Sydney, 2000, Australia
The Private Office of Raymond Douglas

Beverly Hills, California, 90210, United States
USC Roski Eye Institute

Los Angeles, California, 90033, United States
Universitatsmedizin Gottingen

Göttingen, 37075, Germany
University Health Diabetes, Endocrinology & Nephrology Center

Kansas City, Kansas, 64108, United States
University of California, San Francisco

San Francisco, California, 94158, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Colorado - Department of Ophthalmology

Aurora, California, 80045, United States
University of Minnesota, Department of Ophthalmology and Visual Neurosciences

Minneapolis, Minnesota, 55455, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
Vision Medical Research Inc.

Orland Park, Illinois, 60462, United States
West Virgina University Eye Institute

Morgantown, West Virginia, 26506, United States
Western Eye Hospital Imperial College NHS trust

London, United Kingdon, NW1 5QH, United Kingdom

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