Can a new drug ease bulging eyes in thyroid disease?
NCT ID NCT07720635
First seen Jul 22, 2026 · Last updated Jul 24, 2026 · Updated 2 times
Summary
This phase 3 trial tests whether the experimental drug KHN939 can reduce eye bulging and other symptoms in people with moderate-to-severe active thyroid eye disease. About 60 participants in China will receive either KHN939 or a placebo by infusion every three weeks for 21 weeks. The main goal is to see if the drug leads to a meaningful reduction in eye protrusion without worsening the other eye.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an experimental drug called KHN939
- What this could lead to
- If it works, KHN939 could offer a new treatment option for thyroid eye disease, potentially reducing eye bulging and discomfort without surgery.
- What could go wrong
- This is a relatively small, early-phase trial, and the drug may not prove more effective than placebo. Possible side effects are still being evaluated.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, 200135, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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