Can an experimental drug reduce eye bulging in thyroid eye disease?
NCT ID NCT07720648
First seen Jul 22, 2026 · Last updated Jul 24, 2026 · Updated 2 times
Summary
This phase 3 trial is testing whether the experimental drug KHN939 can reduce eye bulging in people with moderate-to-severe inactive thyroid eye disease. About 117 participants in China will receive either KHN939 or a placebo by infusion every three weeks for 21 weeks. The main goal is to see if the drug leads to a meaningful reduction in eye protrusion without worsening the other eye.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an experimental drug called KHN939
- What this could lead to
- If it works, this could offer a new treatment option for thyroid eye disease, potentially reducing eye bulging and improving quality of life.
- What could go wrong
- This is an early-phase trial in a specific population (Chinese patients with inactive disease). The drug may not work as hoped or could cause side effects. Results may not apply to other groups.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for THYROID EYE DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, 200135, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new drug ease bulging eyes in thyroid disease?
- New drug IBI3031 enters first human trial for thyroid eye disease
- New hope for thyroid eye disease: drug shows promise in Steroid-Resistant patients
- Your phone camera could soon spot eye disorders
- Promising drug trial for thyroid eye disease halted early
- Scientists track prednisolone levels to improve dosing for inflammatory conditions