New shot could ease bulging eyes from thyroid disease

NCT ID NCT06248619

Ongoing Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This phase 3 trial tests an injectable drug called teprotumumab for people with moderate-to-severe active thyroid eye disease, a condition that causes eye bulging and discomfort. About 89 adults will receive either the drug or a placebo injection to see if it reduces eye bulging by at least 2 mm. The study is already active but not recruiting, and results may lead to a new treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: teprotumumab (a biologic drug given as a shot under the skin)
What this could lead to: If it works, this could offer a more convenient way to treat thyroid eye disease and reduce eye bulging and inflammation.
What could go wrong: This is still a clinical trial, so it may not work better than placebo. Side effects are possible, and results may not apply to everyone with the condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endocrine exophthalmos Graves Ophthalmopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THYROID EYE DISEASE

Contacts and locations

Locations

AP-HM-Hôpital de La Conception

Marseille, Bouches-du-Rhône, 13010, France
Advanced Quality Medical Research

Orland Park, Illinois, 60462, United States
Azienda Ospedaliera Universitaria Federico II

Naples, Campania, 80131, Italy
Azienda Ospedaliero Universitaria Pisana - Stabilimento Santa Chiara

Pisa, 56124, Italy
Azienda Ospedaliero Universitaria Pisana - Stabilimento di Cisanello

Pisa, 56124, Italy
Baylor College of Medicine-1977 Butler Blvd

Houston, Texas, 77030-4101, United States
CHU de Quebec-Universite Laval CUO Recherche Clinique Hopital du St-Sacrement

Québec, G1S 4L8, Canada
Casey Eye Institute -515 SW Campus Dr

Portland, Oregon, 97239-3130, United States
Catalina Eye Care - NVISION - PPDS

Tucson, Arizona, 85712, United States
Centre For Eye Research Australia Ltd

East Melbourne, Victoria, 3002, Australia
Centro Medico Grupo Laser Vision

Rosario, Santa Fe Province, S2000, Argentina
Changhua Christian Hospital

Changhua County, 50006, Taiwan
Chung Shan Medical University Hospital

Taichung, Taiwan
Gokeikai Osaka Kaisei Hospital

Osaka-Shi Yodogawa-Ku, Ôsaka, 532-0003, Japan
Hayashi Eye Hospital

Fukuoka, Hukuoka, 812-0011, Japan
Hospital Universitari i Politecnic La Fe de Valencia-Avda de Fernando Abril Martorell 106

Valencia, 46026, Spain
Hospital Universitario Austral

Pilar, Buenos Aires, B1629ODT, Argentina
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen Macarena

Seville, 41009, Spain
Ishikawa Prefectural Central Hospital

Kanazawa, Ishikawa-ken, 920-8530, Japan
Kozawa Eye hospital and Diabetes Center

Mito, Ibaraki, 310-0845, Japan
Las Vegas Endocrinology

Henderson, Nevada, 89074, United States
McGill University Health Centre Research Institute

Montreal, Quebec, H4A 3J1, Canada
Moorfields Eye Hospital - PPDS

London, Middlesex, EC1V 2PD, United Kingdom
National Taiwan University Hospital

Taipei, 100, Taiwan
Organización Médica de Investigación

Buenos Aires, Ciudad Autónoma de BuenosAires, C1015ABO, Argentina
Queensland Eye Institute

Wooloongabba, Queensland, 4102, Australia
Royal Adelaide Hospital

Adelaie, South Australia, 5000, Australia
Scheie Eye Institute

Philadelphia, Pennsylvania, 19104-2640, United States
Sydney Eye Hospital

Sydney, New South Wales, 2000, Australia
The Center for Eye and Facial Plastic Surgery

Somerset, New Jersey, 08773, United States
University of Miyazaki Hospital

Miyazaki, Miyazaki, 889-1601, Japan
University of Tennessee Health Science Center - 848 Adams Ave

Memphis, Tennessee, 38103-3452, United States
University of Washington Eye Institute

Seattle, Washington, 98104-2433, United States
Universitätsklinikum Essen

Essen, North Rhine-Westphalia, 45147, Germany
Vancouver Coastal Health Research Institute (VCHRI) - 2550 Willow St

Vancouver, British Columbia, V5Z 3N9, Canada
W Kellogg Eye Center

Ann Arbor, Michigan, 48105-1912, United States
West Virginia University Eye Institute

Morgantown, West Virginia, 26506-1200, United States

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