New targeted drug shows promise for Hard-to-Treat lung cancer

NCT ID NCT06593522

Ongoing Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called anvumetostat in people with a specific genetic form of advanced non-small cell lung cancer (MTAP-deleted NSCLC) that has worsened after prior treatment. The main goals are to see if the drug shrinks tumors and to check its safety. About 61 participants will receive one of two dose levels of the drug.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MTAP-DELETED NSCLC

Contacts and locations

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Locations

Adana Sehir Egitim ve Arastirma Hastanesi

Adana, 01370, Turkey (Türkiye)
Aichi Cancer Center

Nagoya, Aichi-ken, 464-8681, Japan
Ajou University Hospital

Suwon-si Gyeonggi-do, 16499, South Korea
Ankara Bilkent Sehir Hastanesi

Ankara, 06800, Turkey (Türkiye)
Bagcilar Medipol Mega Universite Hastanesi

Istanbul, 34214, Turkey (Türkiye)
Beijing Cancer Hospital

Beijing, Beijing Municipality, 100142, China
Beijing Cancer Hospital

Beijing, 100142, China
Beijing Chest Hospital, Capital Medical University

Beijing, 101149, China
Calvary Mater Newcastle Hospital

Waratah, New South Wales, 2298, Australia
Cancer Research South Australia

Adelaide, South Australia, 5000, Australia
Cancer and Hematology Centers of Western Michigan

Grand Rapids, Michigan, 49503, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Centro Paulista de Oncologia

São Paulo, 04538-132, Brazil
Cha Bundang Medical Center, Cha University

Seongnam-si, Gyeonggi-do, 13496, South Korea
City of Hope National Medical Center

Duarte, California, 91010, United States
City of Hope Orange County Lennar Foundation Cancer Center

Duarte, California, 91010, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut, 06360, United States
Erasmus Medisch Centrum

Rotterdam, 3015 GD, Netherlands
Fakultni Thomayerova nemocnice

Prague, 140 59, Czechia
Fakultni nemocnice Olomouc

Olomouc, 779 00, Czechia
Fund Faculdade Regional Med Sao Jose Rio Preto

São José do Rio Preto, São Paulo, 15090-000, Brazil
Fundacao Antonio Prudente - Hosp AC Camargo

São Paulo, São Paulo, 01509-900, Brazil
Fundacao Champalimaud

Lisbon, 1400-038, Portugal
Fundacao pio xII Barretos

Barretos, São Paulo, 14784-400, Brazil
Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi

Ankara, 06560, Turkey (Türkiye)
GenesisCare -North Shore Oncology

St Leonards, New South Wales, 2065, Australia
Hartford HealthCare Cancer Institute - Manchester

Plainville, Connecticut, 06062, United States
Henan Cancer Hospital

Zhengzhou, Henan, 450001, China
Hopitaux Universitaires de Geneve

Geneva, 1211, Switzerland
Hospital Cuf porto

Porto, 4100-180, Portugal
Hospital Nossa Senhora da Conceicao

Porto Alegre, Rio Grande do Sul, 91010-004, Brazil
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE

Porto, 4200-072, Portugal
Instituto de Educacao Pesquisa e Gestao em Saude

Rio de Janeiro, 22775-001, Brazil
Instituto do Cancer Estado SP Icesp

São Paulo, São Paulo, 01246-000, Brazil
Jilin Cancer Hospital

Changchun, Jilin, 130012, China
Jinan Central Hospital

Jinan, Shandong, 250013, China
Kantonsspital Sankt Gallen

Sankt Gallen, 9007, Switzerland
Liga Norte-Riograndense Contra O Cancer

Natal, Rio Grande do Norte, 59062-000, Brazil
London Health Sciences Centre

London, Ontario, N6A 4L6, Canada
Masarykuv onkologicky ustav

Brno, 656 53, Czechia
Mater Hospital Brisbane

South Brisbane, Queensland, 4101, Australia
McGill University Health Centre Glen Site

Montreal, Quebec, H4A 3J1, Canada
Medstar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
Memorial Bahcelievler Hastanesi

Istanbul, 34180, Turkey (Türkiye)
Mengchao Hepatobiliary Hospital of Fujian Medical University

Fuzhou, Fujian, 350028, China
National Cancer Center Hospital

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East

Kashiwa-shi, Chiba, 277-8577, Japan
National Cancer Centre Singapore

Singapore, 168583, Singapore
National Cheng Kung University Hospital

Tainan, 70403, Taiwan
National Taiwan University Hospital

Taipei, 10002, Taiwan
National University Hospital

Singapore, 119074, Singapore
Nederlands Kanker Instituut Antoni van Leeuwenhoekziekenhuis

Amsterdam, 1066 CX, Netherlands
Núcleo de Oncologia da Bahia

Salvador, Estado de Bahia, 40170-110, Brazil
Our Lady of the Lake Cancer Institute

Baton Rouge, Louisiana, 70808, United States
Pauls Stradins Clinical University Hospital

Riga, 1002, Latvia
Prince of Wales Hospital, Chinese University of Hong Kong

Shatin, New Territories, Hong Kong
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
Queen Mary Hospital, The University of Hong Kong

Hong Kong, Hong Kong
Riga East Clinical University Hospital

Riga, 1079, Latvia
Rocky Mountain Cancer Centers

Denver, Colorado, 80218, United States
Sarah Cannon Research Institute

Dallas, Texas, 75230, United States
Sarah Cannon Research Institute Oncology Partners

Nashville, Tennessee, 37203, United States
Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea
Shanghai East Hospital

Shanghai, Shanghai Municipality, 200123, China
Shizuoka Cancer Center

Sunto-gun, Shizuoka, 411-8777, Japan
Sint Jansdal Ziekenhuis

Harderwijk, 3844 DG, Netherlands
Taichung Veterans General Hospital

Taichung, 40705, Taiwan
Texas Oncology - Dallas Fort Worth

Dallas, Texas, 75246, United States
Texas Oncology Central/South Texas

Austin, Texas, 78745, United States
Texas Oncology Northeast Texas

Tyler, Texas, 75702, United States
The Cancer Institute Hospital of Japanese Foundation for Cancer Research

Koto-ku, Tokyo, 135-8550, Japan
The Catholic University of Korea St Vincents Hospital

Suwon-si, Gyeonggi-do, 16247, South Korea
The First Affiliated Hospital Zhejiang University School Of Medicine

Hangzhou, Zhejiang, 310003, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The Second Xiangya Hospital of Central South University

Changsha, Hunan, 410011, China
Trinity Health Saint Joseph Mercy Ann Arbor

Ann Arbor, Michigan, 48106, United States
US Oncology Research Investigational Products Center

Irving, Texas, 75063, United States
Unidade Local de Saude de Braga, EPE

Braga, 4710-243, Portugal
Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, Hubei, 430022, China
United States Oncology Regulatory Affairs Corporate Office

Nashville, Tennessee, 37203, United States
Universitaetsspital Basel

Basel, 4031, Switzerland
University of California Los Angeles

Los Angeles, California, 90095, United States
Valkyrie Clinical Trials

Los Angeles, California, 90067, United States
Virginia Cancer Specialists PC

Fairfax, Virginia, 22031, United States
Vseobecna fakultni nemocnice v Praze

Prague, 128 08, Czechia
Wakayama Medical University Hospital

Wakayama, Wakayama, 641-8510, Japan
West China Hospital Sichuan University

Chengdu, Sichuan, 610041, China
William Osler Health System - Brampton Civic Hospital

Brampton, Ontario, L6R 3J7, Canada
Zhejiang Cancer Hospital

Hangzhou, Zhejiang, 310005, China