New hope for older leukemia patients: targeted drug combo shows promise
NCT ID NCT04994717
First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This Phase 3 trial is testing whether a targeted immunotherapy drug called blinatumomab, given alongside low-intensity chemotherapy, works better than standard chemotherapy for older adults (55+) with a specific type of acute lymphoblastic leukemia (ALL). The study involves 303 participants and aims to see if the new combination improves survival and reduces the chance of the cancer coming back. The trial is no longer recruiting, and results are awaited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Blinatumomab (Blincyto) and low-intensity chemotherapy
What this could lead to
If successful, this could offer a more effective and less toxic treatment option for older adults with a hard-to-treat leukemia, potentially improving survival and reducing relapse.
What could go wrong
This is a Phase 3 trial, but results are not yet available. The experimental combination may not prove better than standard chemo, and side effects like infections or neurological issues remain a concern.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AZ Delta Campus Rumbeke
Roeselare, 8800, Belgium
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AZ Sint-Jan Brugge-Oostende AV
Bruges, 8000, Belgium
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Aalborg Universitetshospital
Aalborg, 9000, Denmark
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Aarhus Universitetshospital
Aarhus N, 8200, Denmark
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Adventist Health System/Sunbelt, Inc d/b/a AdventHealth Orlando
Orlando, Florida, 32804, United States
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Akita University Hospital
Akita, Akita, 010-8543, Japan
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Ankara Bilkent Sehir Hastanesi
Ankara, 06800, Turkey (Türkiye)
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Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, T2N 5G2, Canada
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Attiko General University Hospital
Athens, 12462, Greece
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Austin Health, Austin Hospital
Heidelberg, Victoria, 3084, Australia
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Azienda Ospedaliera Policlinico Umberto I
Roma, 00161, Italy
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Azienda Ospedaliera Universitaria Consorziale Policlinico di Bari
Bari, 70124, Italy
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Azienda Ospedaliera Universitaria Integrata di Verona Ospedale G B Rossi Borgo Roma
Verona, 37134, Italy
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Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia
Perugia, 06156, Italy
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Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli
Naples, 80131, Italy
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Azienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino
Torino, 10126, Italy
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Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii
Bergamo, 24127, Italy
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Azienda Unita Sanitaria Locale LE Presidio Ospedaliero Vito Fazzi Polo Oncologico Giovanni Paolo II
Lecce, 73100, Italy
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Azienda Unita Sanitaria Locale Pescara Ospedale Civile Santo Spirito
Pescara, 65124, Italy
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Azienda Unità Locale Socio Sanitaria 3 Ospedale Dell Angelo
Mestre (VE), 30174, Italy
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Bagcilar Medipol Mega Universite Hastanesi
Istanbul, 34214, Turkey (Türkiye)
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Boca Clinical Trials Mexico SC
Mexico City, Mexico City, 01120, Mexico
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CEMTL Hopital Maisonneuve Rosemont
Montreal, Quebec, H1T 2M4, Canada
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Canberra Hospital
Garran, Australian Capital Territory, 2605, Australia
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Cancer Care Manitoba
Winnipeg, Manitoba, R3H 0V9, Canada
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Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez
Lille, 59000, France
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Centre Hospitalier Universitaire Archet 2
Nice, 06202, France
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Centre Hospitalier Universitaire de Bordeaux - Hopital Haut Leveque
Pessac, 33604, France
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Centre Hospitalier Universitaire de Dijon - Hopital du Bocage
Dijon, 21000, France
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Centre Hospitalier Universitaire de Liege - Sart Tilman
Liège, 4000, Belgium
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Centre Hospitalier Universitaire de Nancy - Hopital de Brabois
Vandœuvre-lès-Nancy, 54511, France
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Centre Hospitalier Universitaire de Nantes - Hopital Hotel Dieu
Nantes, 44000, France
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Centre Hospitalier Universitaire de Rennes
Rennes, 35000, France
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Centre Hospitalier Universitaire-Universite Catholique de Louvain Namur-Site Godinne
Yvoir, 5530, Belgium
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Centre Hospitalier de Versailles - Hopital Andre Mignot
Le Chesnay, 78157, France
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Centro Oncologico Internacional
Mexico City, Mexico City, 01330, Mexico
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Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin
Berlin, 12203, Germany
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China Medical University Hospital
Taichung, 40458, Taiwan
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Chonnam National University Hwasun Hospital
Hwasun, 58128, South Korea
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Chungnam National University Hospital
Daejeon, 35015, South Korea
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City of Hope National Medical Center
Duarte, California, 91010, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Clinica Alemana de Santiago
Santiago, 7650729, Chile
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Complejo Asistencial Universitario de Salamanca Hospital Universitario de Salamanca
Salamanca, Castille and León, 37007, Spain
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Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032, Hungary
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Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
Budapest, 1097, Hungary
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Dokuz Eylul Universitesi Tip Fakultesi Hastanesi
Izmir, 35340, Turkey (Türkiye)
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Dong-A University Hospital
Busan, 49201, South Korea
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Evangelismos Hospital
Athens, 10676, Greece
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Fakultni nemocnice Brno
Brno, 625 00, Czechia
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Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05, Czechia
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Fiona Stanley Hospital
Murdoch, Western Australia, 6150, Australia
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Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Fukushima Medical University Hospital
Fukushima, Fukushima, 960-1295, Japan
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Fundacao Amaral Carvalho
Jaú, São Paulo, 17210-120, Brazil
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Fundacion Arturo Lopez Perez
Santiago, 7500921, Chile
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General Hospital of Thessaloniki Georgios Papanikolaou
Thessaloniki, 57010, Greece
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Gunma Saiseikai Maebashi Hospital
Maebashi, Gunma, 371-0821, Japan
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Hacettepe Universitesi Tip Fakultesi Hastanesi
Ankara, 06100, Turkey (Türkiye)
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Hamilton Health Sciences - Juravinski Hospital and Cancer Centre
Hamilton, Ontario, L8V 5C2, Canada
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Hanusch Krankenhaus
Vienna, 1140, Austria
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Helsinki University Hospital
Helsinki, 00029, Finland
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Hematologica Alta Especialidad
Huixquilucan, 52787, Mexico
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Hemorio
Rio de Janeiro, 22640-000, Brazil
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Heves Varmegyei Markhot Ferenc Oktatokorhaz es Rendelointezet
Eger, 3300, Hungary
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Hopital Henri Mondor
Créteil, 94010, France
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Hopital Lyon Sud
Pierre-Bénite, 69645, France
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Hopital Saint Antoine
Paris, 75012, France
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Hopital Saint Louis
Paris, 75010, France
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Hosp Clin Fac Med Ribeirao Preto Usp
Ribeirão Preto, São Paulo, 14048-900, Brazil
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Hospital Universitari Vall d Hebron
Barcelona, Catalonia, 08035, Spain
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Hospital Universitari i Politecnic La Fe
Valencia, Valencia, 46026, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Dr Jose Eleuterio Gonzalez
Monterrey, Nuevo León, 64460, Mexico
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Hospital Universitario Marques de Valdecilla
Santander, Cantabria, 39008, Spain
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Hospital Universitario Reina Sofia
Córdoba, Andalusia, 14004, Spain
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Hospital Universitario Virgen del Rocio
Seville, Andalusia, 41013, Spain
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Hospital das Clinicas da Universidade Federal de Goias
Goiânia, Goiás, 74605-020, Brazil
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Hospital de Base de Sao Jose do Rio Preto
São Jose Do Rio Preto, São Paulo, 15090-000, Brazil
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Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-003, Brazil
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IRCCS Azienda Ospedaliera Metropolitana
Genova, 16132, Italy
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IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola
Bologna, 40138, Italy
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Igesd Instituto de Gestao Estrategica da Saude do Distrito Federal
Brasília, Federal District, 70335-902, Brazil
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Inmunocel
Santiago, 7580206, Chile
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Inselspital Bern
Bern, 3010, Switzerland
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Institut Catala d Oncologia Badalona Hospital Universitari Germans Trias i Pujol
Badalona, Catalonia, 08916, Spain
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Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals
L'Hospitalet de Llobregat, Catalonia, 08908, Spain
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Institut Jules Bordet
Anderlecht, 1070, Belgium
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Institut Paoli Calmettes
Marseille, 13009, France
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Institut Universitaire du Cancer Toulouse Oncopole
Toulouse, 31059, France
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Instituto Cancer Sao Paulo Icesp
São Paulo, 01246-000, Brazil
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Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, 14080, Mexico
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Instituto Portugues de Oncologia de Lisboa Francisco Gentil, EPE
Lisbon, 1099-023, Portugal
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Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
Porto, 4200-072, Portugal
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Institutul Clinic Fundeni
Bucharest, 022328, Romania
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Institutul Oncologic Prof Dr Ion Chiricuta
Cluj-Napoca, 400015, Romania
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Institutul Regional de Oncologie Iasi
Iași, 700483, Romania
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Jessa Ziekenhuis - Campus Virga Jesse
Hasselt, 3500, Belgium
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Jichi Medical University Hospital
Shimotsuke-shi, Tochigi, 329-0498, Japan
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Kanazawa University Hospital
Kanazawa, Ishikawa-ken, 920-8641, Japan
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Kindai University Hospital
Sakai-shi, Osaka, 590-0197, Japan
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Kings College Hospital
London, SE5 9RS, United Kingdom
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Klinikum der LMU Muenchen
München, 81377, Germany
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Kobe City Medical Center General Hospital
Kobe, Hyōgo, 650-0047, Japan
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Kurume University Hospital
Kurume-shi, Fukuoka, 830-0011, Japan
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Kyoto University Hospital
Kyoto, Kyoto, 606-8507, Japan
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Kyushu University Hospital
Fukuoka, Fukuoka, 812-8582, Japan
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Laiko General Hospital of Athens
Athens, 11527, Greece
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Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
Taoyuan, 33305, Taiwan
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Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
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Medizinische Universitaet Graz
Graz, 8036, Austria
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Medizinische Universitaet Innsbruck
Innsbruck, 6020, Austria
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Memorial Antalya Hastanesi
Antalya, 07025, Turkey (Türkiye)
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Monash Medical Centre
Clayton, Victoria, 3168, Australia
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Nagasaki University Hospital
Nagasaki, Nagasaki, 852-8501, Japan
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Nagoya University Hospital
Nagoya, Aichi-ken, 466-8560, Japan
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Narodny onkologicky ustav
Bratislava, 833 10, Slovakia
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National Cheng Kung University Hospital
Tainan, 70403, Taiwan
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National Hospital Organization Okayama Medical Center
Okayama, Okayama-ken, 701-1192, Japan
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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Nihon University Itabashi Hospital
Itabashi-ku, Tokyo, 173-8610, Japan
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North Estonia Medical Centre
Tallinn, 13 419, Estonia
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Odense Universitetshospital
Odense, 5000, Denmark
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Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
Samsun, 55139, Turkey (Türkiye)
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Ordensklinikum Linz Elisabethinen
Linz, 4020, Austria
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Osaka Metropolitan University Hospital
Osaka, Osaka, 545-8586, Japan
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Peter MacCallum Cancer Centre
Melbourne, Victoria, 3000, Australia
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Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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Princess Margaret Hospital
Kowloon, Hong Kong
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Pusan National University Hospital
Busan, 49241, South Korea
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Queen Elizabeth II, Health Sciences Centre
Halifax, Nova Scotia, B3H 1V8, Canada
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Queen Mary Hospital, The University of Hong Kong
Hong Kong, Hong Kong
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Rabin Medical Center - Beilinson Hospital
Petah Tikva, 4941492, Israel
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Rambam Medical Center
Haifa, 3109601, Israel
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Rigshospitalet
København Ø, 2100, Denmark
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Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
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Royal Brisbane and Womens Hospital
Herston, Queensland, 4029, Australia
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Royal North Shore Hospital
St Leonards, New South Wales, 2065, Australia
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Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia
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Sahlgrenska Universitetssjukhuset
Gothenburg, 413 45, Sweden
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Saint Francis Hospital, Inc
Greenville, South Carolina, 29607, United States
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Sapporo Hokuyu Hospital
Sapporo, Hokkaido, 003-0006, Japan
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Semmelweis Egyetem
Budapest, 1088, Hungary
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital Yonsei University Health System
Seoul, 03722, South Korea
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Shaare Zedek Medical Center
Jerusalem, 9103102, Israel
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Specialized Hospital for Active Treatment of Hematology Diseases EAD
Sofia, 1797, Bulgaria
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Spitalul Clinic Judetean de Urgenta Sibiu
Sibiu, 550245, Romania
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Spitalul Clinic Municipal Filantropia Craiova
Craiova, 200143, Romania
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Spitalul Universitar de Urgenta Bucuresti
Bucharest, 050098, Romania
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Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz
Nyíregyháza, 4400, Hungary
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Taichung Veterans General Hospital
Taichung, 40705, Taiwan
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Tartu University Hospital
Tartu, 51014, Estonia
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Tesshokai Kameda General Hospital
Kamogawa-shi, Chiba, 296-8602, Japan
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The Alfred Hospital
Melbourne, Victoria, 3004, Australia
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The Catholic University of Korea Seoul St Marys Hospital
Seoul, 06591, South Korea
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The Ottawa Hospital Cancer Centre
Ottawa, Ontario, K1H 8L6, Canada
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Tohoku University Hospital
Sendai, Miyagi, 980-8574, Japan
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Tokai University Hospital
Isehara-shi, Kanagawa, 259-1193, Japan
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Tokyo Metropolitan Komagome Hospital
Bunkyo-ku, Tokyo, 113-8677, Japan
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Tuen Mun Hospital
New Territories, Hong Kong
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Turku University Hospital
Turku, 20521, Finland
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Unidade Local de Saude de Coimbra, EPE
Coimbra, 3004-561, Portugal
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Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria
Lisbon, 1649-035, Portugal
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Unidade Local de Saude de Sao Jose, EPE - Hospital de Santo Antonio dos Capuchos
Lisbon, 1169-050, Portugal
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Universitaetsklinikum Augsburg
Augsburg, 86156, Germany
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Universitaetsklinikum Dresden
Dresden, 01307, Germany
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Universitaetsklinikum Duesseldorf
Düsseldorf, 40225, Germany
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Universitaetsklinikum Heidelberg
Heidelberg, 69120, Germany
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Universitaetsklinikum Jena
Jena, 07747, Germany
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Universitaetsklinikum Schleswig-Holstein - Kiel
Kiel, 24105, Germany
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Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
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Universitair Ziekenhuis Antwerpen
Edegem, 2650, Belgium
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Universitair Ziekenhuis Gent
Ghent, 9000, Belgium
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Universite Catholique de Louvain Cliniques Universitaires Saint Luc
Brussels, 1200, Belgium
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University College London
London, NW1 2PG, United Kingdom
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University Hospital of Heraklion
Heraklion, 71500, Greece
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University Hospital of Ioannina
Ioannina, 45500, Greece
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University Hospital of Larissa
Larissa, 41110, Greece
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University Hospital of Patras
Pátrai, 26504, Greece
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University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
Plovdiv, 40002, Bulgaria
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University of California Irvine
Orange, California, 92868-3201, United States
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University of California San Francisco
San Francisco, California, 94143, United States
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University of Fukui Hospital
Yoshida-gun, Fukui, 910-1193, Japan
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Univerzitna nemocnica Bratislava, Nemocnica sv Cyrila a Metoda
Bratislava, 851 07, Slovakia
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Ustav hematologie a krevni transfuze
Prague, 128 20, Czechia
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Vancouver General Hospital, Gordon and Leslie Diamond Health Care Centre
Vancouver, British Columbia, V5Z 1M9, Canada
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Westmead Hospital
Westmead, New South Wales, 2145, Australia
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Yamagata University Hospital
Yamagata, Yamagata, 990-9585, Japan
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Yokohama City University Medical Center
Yokohama, Kanagawa, 232-0024, Japan