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New injectable drug shows promise for tough lung cancer

NCT ID NCT06598306

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing a drug called tarlatamab, given as a shot under the skin, for people with extensive stage small cell lung cancer that has worsened after standard chemotherapy. The main goals are to check safety and side effects, and to see how the drug behaves in the body. About 220 adults will take part in this study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tarlatamab (a drug given as a shot under the skin)
What this could lead to
If it works, this could offer a more convenient way to treat small cell lung cancer that has spread and stopped responding to standard chemotherapy.
What could go wrong
This is an early Phase 1b trial focused on safety, not yet on effectiveness. The drug may cause side effects or not shrink tumors. Results are preliminary and may not lead to a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTENSIVE-STAGE SMALL-CELL LUNG CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Adana Sehir Egitim ve Arastirma Hastanesi

    RECRUITING

    Adana, 01370, Turkey (Türkiye)

  • Ankara Bilkent Sehir Hastanesi

    RECRUITING

    Ankara, 06800, Turkey (Türkiye)

  • Avera Cancer Institute

    RECRUITING

    Sioux Falls, South Dakota, 57105, United States

  • Calvary Mater Newcastle Hospital

    RECRUITING

    Waratah, New South Wales, 2298, Australia

  • Centre Hospitalier Universitaire de Liege - Sart Tilman

    RECRUITING

    Liège, 4000, Belgium

  • Chris OBrien Lifehouse

    RECRUITING

    Camperdown, New South Wales, 2050, Australia

  • Freiburg Spital

    RECRUITING

    Fribourg, 1708, Switzerland

  • Hospital Regional Universitario de Malaga

    RECRUITING

    Málaga, Andalusia, 29011, Spain

  • Hospital Universitari Vall d Hebron

    RECRUITING

    Barcelona, Catalonia, 08035, Spain

  • Hospital Universitari i Politecnic La Fe

    RECRUITING

    Valencia, Valencia, 46026, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Instytut Centrum Zdrowia Matki Polki

    RECRUITING

    Lodz, 93-338, Poland

  • Jilin Cancer Hospital

    RECRUITING

    Changchun, Jilin, 130012, China

  • Kantonsspital Graubuenden

    RECRUITING

    Chur, 7000, Switzerland

  • Kantonsspital Winterthur

    RECRUITING

    Winterthur, 8401, Switzerland

  • Koc Universitesi Hastanesi

    RECRUITING

    Istanbul, 34010, Turkey (Türkiye)

  • Okayama University Hospital

    RECRUITING

    Okayama, Okayama-ken, 700-8558, Japan

  • Shanghai Pulmonary Hospital

    RECRUITING

    Shanghai, Shanghai Municipality, 200433, China

  • Swedish Cancer Institute

    RECRUITING

    Seattle, Washington, 98104, United States

  • The Alfred Hospital

    RECRUITING

    Melbourne, Victoria, 3004, Australia

  • Trinity Health Saint Joseph Mercy Ann Arbor

    RECRUITING

    Ann Arbor, Michigan, 48106, United States

  • Universitaetsklinikum Regensburg

    RECRUITING

    Regensburg, 93053, Germany

  • Universitaetsklinikum Wuerzburg

    RECRUITING

    Würzburg, 97078, Germany

  • Universitair Ziekenhuis Gent

    RECRUITING

    Ghent, 9000, Belgium

  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg

    RECRUITING

    Leuven, 3000, Belgium

  • University of Illinois Chicago

    RECRUITING

    Chicago, Illinois, 60612, United States

  • University of Southern California, Norris Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90033, United States

  • University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Uniwersyteckie Centrum Kliniczne

    RECRUITING

    Gdansk, 80-214, Poland

  • Wakayama Medical University Hospital

    RECRUITING

    Wakayama, Wakayama, 641-8510, Japan

  • Wojewodzki Szpital im Sw Ojca Pio w Przemyslu

    RECRUITING

    Przemyśl, 37-700, Poland

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