New hope for kids with rare nerve disease: drug trial launches

NCT ID NCT05549258

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a drug called inebilizumab in 15 children aged 2 to 17 with neuromyelitis optica spectrum disorder (NMOSD), a rare condition where the immune system attacks the optic nerves and spinal cord. The drug aims to reduce relapses by targeting certain immune cells. Researchers will measure how the drug moves through the body, its safety, and whether it helps control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: inebilizumab
What this could lead to: If successful, this trial could show that inebilizumab is a safe and effective option to reduce relapses in children with NMOSD.
What could go wrong: This is a small, early-phase study with only 15 participants, so results may not apply to all patients. Side effects are possible, and the drug may not work as well in children as in adults.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neuromyelitis optica

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROMYELITIS OPTICA SPECTRUM DISORDER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Birmingham Women's and Children's NHS Foundation Trust
RECRUITING

Birmingham, West Midlands, B4 6NH, United Kingdom
CPQuali Pesquisa Clínica Sao Paulo
RECRUITING

São Paulo, 01228-000, Brazil
Centre Hospitalier Universitaire de Bicêtre
RECRUITING

Le Kremlin-Bicêtre, Val-de-Marne, 94275, France
Clinic for Neurology and Psychiatry for Children and Youth
RECRUITING

Belgrade, Belgrade, 11000, Serbia
Erasmus MC Sophia Children's Hospital-Wytemaweg 80
RECRUITING

Rotterdam, South Holland, 3015 GD, Netherlands
Evelina London Children's Hospital
RECRUITING

London, London, City of, SE1 7EH, United Kingdom
Great Ormond Street Hospital - PPDS
RECRUITING

London, London, City of, WC1N 3JH, United Kingdom
Hospital For Sick Children
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
Hospital Sant Joan de Deu - PIN
RECRUITING

Espluges de Llobregat, Barcelona, 08950, Spain
Hospital Santa Izabel-Rua Floriano Peixoto 300
RECRUITING

Salvador, Estado de Bahia, 40050-410, Brazil
Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS)
RECRUITING

Porto Alegre/RS, 90610-000, Brazil
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
RECRUITING

São Paulo, 05403-000, Brazil
Hospital de Pediatría S.A.M.I.C.- Prof. Dr. Juan P. Garrahan
RECRUITING

Parque Patricios, Ciudad Autónoma de BuenosAires, C1245AAM, Argentina
Karolinska Universitetssjukhuset Solna
RECRUITING

Stockholm, Stockholm County, 17176, Sweden
Loma Linda University Children's Hospital - PIN
RECRUITING

Loma Linda, California, 92354, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
UCSD Altman Clinical and Translational Research Institute Building
RECRUITING

La Jolla, California, 92037-1337, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 78701, United States
Uniwersyteckie Centrum Kliniczne w Gdansku - Smoluchowskiego 17
RECRUITING

Gdansk, 80-952, Poland

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