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Second chance: new drug tested for stubborn thyroid eye disease

NCT ID NCT07438405

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tests a drug called AMG 732 in 30 adults with thyroid eye disease who either did not respond to treatment or saw their symptoms return after a previous study. The main goal is to see if the drug can reduce eye bulging by at least 2 millimeters without worsening the other eye. Participants will receive the drug as an injection under the skin.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
AMG 732 (a drug given as an injection under the skin)
What this could lead to
If successful, this could offer a treatment option for thyroid eye disease patients who did not improve or relapsed after initial therapy.
What could go wrong
This is a small, early-phase rollover study with only 30 participants, so results may not apply broadly. The drug may not work for all patients, and side effects are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endocrine exophthalmos Graves Ophthalmopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THYROID EYE DISEASE

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Applied Research Center of Arkansas

    RECRUITING

    Little Rock, Arkansas, 72205, United States

  • Eb Group Spolka z ograniczona odpowiedzialnoscia

    RECRUITING

    Warsaw, 00-189, Poland

  • Hospital Universitari i Politecnic La Fe

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Universitario Virgen Macarena

    RECRUITING

    Seville, Andalusia, 41009, Spain

  • Ilumina Medical Research

    RECRUITING

    Kissimmee, Florida, 34744, United States

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 10002, Taiwan

  • Vision Medical Research, Inc.

    RECRUITING

    Orland Park, Illinois, 60462, United States

  • West Virginia University

    RECRUITING

    Morgantown, West Virginia, 26506, United States

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