New drug avacopan under Long-Term safety review for vasculitis patients

NCT ID NCT06072482

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 5 times

Summary

This study is checking the long-term safety of a drug called avacopan for people with ANCA-associated vasculitis, a rare disease where the immune system attacks blood vessels. About 300 adults who need treatment for a new diagnosis or flare-up will take avacopan or a placebo. The main goal is to see what side effects occur over time.

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Conditions

The condition(s) this trial relates to.

anti-neutrophil cytoplasmic antibody-associated vasculitis granulomatosis with polyangiitis microscopic polyangiitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Aalborg Universitetshospital
ACTIVE_NOT_RECRUITING

Aalborg, 9000, Denmark
Allegheny Health Network Cancer Institute at Mellon Pavilion
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Amicis Research Center
RECRUITING

Valencia, California, 91355, United States
Brigham and Womens Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Brookview Hills Research Associates Llc
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Carolina Kidney Associates
RECRUITING

Greensboro, North Carolina, 27405, United States
Carolina Nephrology PA
RECRUITING

Spartanburg, South Carolina, 29306, United States
ClinTrial Research Oakwater, Llc
RECRUITING

Orlando, Florida, 32806, United States
Clinical Research Institute of Michigan
RECRUITING

Saint Clair Shores, Michigan, 48081, United States
Dartmouth Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03766, United States
Debreceni Egyetem Klinikai Kozpont
ACTIVE_NOT_RECRUITING

Debrecen, 4032, Hungary
Dunes Clinical Research LLC
RECRUITING

Sioux City, Iowa, 51104, United States
East Carolina University Brody Outpatient Center
RECRUITING

Greenville, North Carolina, 27834, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Epic Medical Research - Red Oak
RECRUITING

Red Oak, Texas, 75154, United States
Fakultni nemocnice Hradec Kralove
ACTIVE_NOT_RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice Kralovske Vinohrady
ACTIVE_NOT_RECRUITING

Prague, 100 34, Czechia
Fakultni nemocnice Olomouc
ACTIVE_NOT_RECRUITING

Olomouc, 779 00, Czechia
Fakultni nemocnice Ostrava
ACTIVE_NOT_RECRUITING

Ostrava - Poruba, 708 52, Czechia
Fakultni nemocnice Plzen
ACTIVE_NOT_RECRUITING

Pilsen, 304 60, Czechia
Florida Kidney Physicians
RECRUITING

Boca Raton, Florida, 33431, United States
General Hospital of Athens Laiko
ACTIVE_NOT_RECRUITING

Athens, 11527, Greece
Harbor University of California at Los Angeles Medical Center
RECRUITING

Torrance, California, 90502, United States
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Hightower Clinical
RECRUITING

Oklahoma City, Oklahoma, 73114, United States
Hippokration General Hospital of Athens
ACTIVE_NOT_RECRUITING

Athens, 11527, Greece
Hospital For Special Surgery
RECRUITING

New York, New York, 10021, United States
Johns Hopkins Bayview Medical Center
RECRUITING

Baltimore, Maryland, 21224, United States
Kidney Michigan Institute
RECRUITING

Saginaw, Michigan, 49804, United States
Lake Cumberland Rheumatology
RECRUITING

New Albany, Indiana, 47150, United States
Malcom Randall Veterans Affairs Medical Center
RECRUITING

Gainesville, Florida, 32608, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Medvin Clinical Research
TERMINATED

Covina, California, 91722, United States
Narodowy Instytut Geriatrii Reumatologii i Rehabilitacji im prof dr hab med Eleonory Reicher
ACTIVE_NOT_RECRUITING

Warsaw, 02-637, Poland
Nephrology Associates Inc
RECRUITING

East Providence, Rhode Island, 02914, United States
Nephrology Associates of Northern Virginia Inc
RECRUITING

Fairfax, Virginia, 22033, United States
New York Nephrology Vasculitis and Glomerular Center
RECRUITING

Albany, New York, 12209, United States
Northwell Health
RECRUITING

Great Neck, New York, 11021, United States
Odense Universitetshospital
ACTIVE_NOT_RECRUITING

Odense C, 5000, Denmark
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Orthopedic Physicians Alaska
TERMINATED

Anchorage, Alaska, 99508, United States
Palo Alto Medical Foundation Fremont
RECRUITING

Fremont, California, 94538, United States
Pecsi Tudomanyegyetem Klinikai Kozpont
ACTIVE_NOT_RECRUITING

Pécs, 7632, Hungary
Providence Medical Foundation
RECRUITING

Fullerton, California, 92835, United States
Renal Disease Research Institute - Landry Office
RECRUITING

Dallas, Texas, 75204, United States
Renal Medicine Associates
RECRUITING

Albuquerque, New Mexico, 87109, United States
Renown Rheumatology
RECRUITING

Reno, Nevada, 89502, United States
Revive Research Institute
RECRUITING

Sterling Heights, Michigan, 48313, United States
Revmatologicky ustav
ACTIVE_NOT_RECRUITING

Prague, 128 00, Czechia
Rheumatology and Pulmonary Clinic
RECRUITING

Beckley, West Virginia, 25801, United States
Rigshospitalet
ACTIVE_NOT_RECRUITING

Copenhagen, 2100, Denmark
SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im Norberta Barlickiego Uniwersytetu Medycznego w Lodzi
ACTIVE_NOT_RECRUITING

Lodz, 90-153, Poland
Scott and White Memorial Hospital
RECRUITING

Temple, Texas, 76502, United States
Scottsdale Healthcare at Shea - HonorHealth
RECRUITING

Scottsdale, Arizona, 85258, United States
Southland Arthritis and Osteoarthritis Medical Center, Inc
RECRUITING

Menifee, California, 92586, United States
Southwest Kidney Institute
RECRUITING

Surprise, Arizona, 85374, United States
Spitalul Clinic Dr Ion Cantacuzino
ACTIVE_NOT_RECRUITING

Bucharest, 020475, Romania
Spitalul Clinic Judetean de Urgenta Cluj
ACTIVE_NOT_RECRUITING

Cluj-Napoca, 400006, Romania
Spitalul Clinic Sf Maria, Bucuresti
ACTIVE_NOT_RECRUITING

Bucharest, 011172, Romania
Spzoz Centralny Szpital Kliniczny Umed w Lodzi
ACTIVE_NOT_RECRUITING

Lodz, 92-213, Poland
Stat Research
RECRUITING

Miamisburg, Ohio, 45342, United States
The Nephrology Group
RECRUITING

Fresno, California, 93720, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43201, United States
Unity Health
RECRUITING

Searcy, Arkansas, 72143, United States
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of California San Francisco- Zuckerburg San Francisco General
RECRUITING

San Francisco, California, 94110, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky
RECRUITING

Lexington, Kentucky, 40536, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55414, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of South Florida
RECRUITING

Tampa, Florida, 33606, United States
Vanderbilt University Medical Center
TERMINATED

Nashville, Tennessee, 37232, United States
Virginia Mason Medical Center
TERMINATED

Seattle, Washington, 98101, United States
Vital Rheumatology
RECRUITING

Austin, Texas, 78727, United States
Vseobecna fakultni nemocnice v Praze
ACTIVE_NOT_RECRUITING

Prague, 128 08, Czechia
West Tennessee Research Institute
RECRUITING

Jackson, Tennessee, 38305, United States
Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy Centralny Szpital Kliniczny Mon
ACTIVE_NOT_RECRUITING

Warsaw, 04-141, Poland

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