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Hydroxychloroquine trial for rare vasculitis halted early

NCT ID NCT04316494

Terminated Disease control Sponsor: Guy's and St Thomas' NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether hydroxychloroquine, a drug used for lupus and arthritis, could help control ANCA vasculitis—a group of autoimmune diseases that cause blood vessel inflammation. Adults with mild disease activity were randomly assigned to receive hydroxychloroquine or a placebo alongside their usual treatments for one year. The trial was terminated early after enrolling 43 of the planned 76 participants.

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Conditions

The condition(s) this trial relates to.

anti-neutrophil cytoplasmic antibody-associated vasculitis eosinophilic granulomatosis with polyangiitis granulomatosis with polyangiitis microscopic polyangiitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANCA-ASSOCIATED VASCULITIS CHURG-STRAUSS SYNDROME MICROSCOPIC POLYANGIITIS WEGENER GRANULOMATOSIS

Contacts and locations

Locations

  • Cambridge University Hospitals NHS Foundation Trust

    Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom

  • Cardiff & Vale University Health Board

    Cardiff, CF14 4XW, United Kingdom

  • Cwm Taf Morgannwg University Health Board

    Llantrisant, United Kingdom

  • East and North Hertfordshire NHS Trust

    Stevenage, Hertfordshire, SG1 4AB, United Kingdom

  • Epsom and St Helier University Hospitals NHS Trust

    Epsom, United Kingdom

  • Guy's and St Thomas' NHS Foundation Trust

    London, SE1 9RT, United Kingdom

  • Imperial College Healthcare NHS Trust

    London, W12 0HS, United Kingdom

  • King's College Hospital NHS Foundation Trust

    London, SE5 9RS, United Kingdom

  • Liverpool University Hospitals NHS Foundation Trust

    Liverpool, Merseyside, L9 7AL, United Kingdom

  • NHS Highland

    Inverness, Inverness-shire, IV2 3JH, United Kingdom

  • Oxford University Hospitals NHS Foundation Trust

    Oxford, United Kingdom

  • Royal Berkshire NHS Foundation Trust

    Reading, Berkshire, RG1 5AN, United Kingdom

  • Royal United Hospitals Bath NHS Foundation Trust

    Bath, Somerset, BA1 3NG, United Kingdom

  • South Tyneside and Sunderland NHS Foundation Trust

    Sunderland, United Kingdom

  • Surrey and Sussex Healthcare NHS Trust

    Redhill, Surrey, RH1 5RH, United Kingdom

  • Torbay and South Devon NHS Foundation Trust

    Torquay, United Kingdom

  • University Hospitals Sussex NHS Foundation Trust

    Brighton, Sussex, BN2 5BE, United Kingdom

  • University Hospitals of Leicester NHS Trust

    Leicester, Leicestershire, LE3 9QP, United Kingdom

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