New obesity drug aims to help keep weight off after switching from popular injections

NCT ID NCT07575399

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether switching from common GLP-1 weight-loss drugs to a new medication called maridebart cafraglutide can help adults with obesity or overweight maintain their weight loss. About 300 participants who have already lost at least 10% of their body weight on a GLP-1 drug will receive injections of the new drug. The main goal is to see how body weight changes over 68 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: maridebart cafraglutide (AMG 133)
What this could lead to: If successful, this could offer a new option for people with obesity to maintain weight loss after switching from common GLP-1 medications.
What could go wrong: This is an early-phase 3 trial with only 300 participants, so results may not apply to everyone. Side effects or lack of weight maintenance are possible risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OR OVERWEIGHT

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Accellacare Research of Wilmington
RECRUITING

Wilmington, North Carolina, 28401, United States
Accellacare of Raleigh
RECRUITING

Raleigh, North Carolina, 27609, United States
Aga Clinical Trials
RECRUITING

Hialeah, Florida, 33012, United States
Altoona Center for Clinical Research
RECRUITING

Duncansville, Pennsylvania, 16635, United States
Apex Clinical Research
RECRUITING

San Diego, California, 92120, United States
Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division
RECRUITING

Troy, Michigan, 48098, United States
Arizona Clinical Trials
RECRUITING

Chandler, Arizona, 85224, United States
Biopharma Informatic, LLC
RECRUITING

Houston, Texas, 77043, United States
Cahaba Research, Inc.
RECRUITING

Pelham, Alabama, 35124, United States
Centricity Research Morehead City Specialty
RECRUITING

Morehead City, North Carolina, 28557, United States
Charter Research - The Villages
RECRUITING

The Villages, Florida, 32162, United States
Clinical Neuroscience Solutions
RECRUITING

Orlando, Florida, 32801, United States
Desert Oasis Healthcare Medical Group
RECRUITING

Palm Springs, California, 92262, United States
Eastside Research Associates Health Research
RECRUITING

Redmond, Washington, 98052, United States
Endeavor Health
RECRUITING

Skokie, Illinois, 60077, United States
Epic Medical Research - DeSoto
RECRUITING

DeSoto, Texas, 75115, United States
Epic Medical Research - Oklahoma
RECRUITING

Chickasha, Oklahoma, 73018, United States
Epic Medical Research - Sun City
RECRUITING

Sun City, Arizona, 85351, United States
Excel Clinical Research
RECRUITING

Las Vegas, Nevada, 89109, United States
Florida Institute for Clinical Research
RECRUITING

Orlando, Florida, 32825, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Inland Empire Liver Foundation
RECRUITING

Rialto, California, 92377, United States
Lynn Health Science Institute
RECRUITING

Oklahoma City, Oklahoma, 73112, United States
New Horizon Research Center
RECRUITING

Miami, Florida, 33165, United States
North Georgia Clinical Research
RECRUITING

Woodstock, Georgia, 30189, United States
North Hills Medical Research
RECRUITING

North Richland Hills, Texas, 76180, United States
Northwest Houston Heart Center
RECRUITING

Tomball, Texas, 77375, United States
Nsc Research
RECRUITING

Johns Creek, Georgia, 30024, United States
Peninsula Research Associates
RECRUITING

Rolling Hills Estates, California, 90274, United States
Pennington Biomedical Research Center
RECRUITING

Baton Rouge, Louisiana, 70808, United States
Progressive Medical Research
RECRUITING

Port Orange, Florida, 32127, United States
Puerto Rico Medical Research Inc.
RECRUITING

Ponce, 00717, Puerto Rico
Research Institute of South Florida
RECRUITING

Miami, Florida, 33173, United States
Research Physicians Network, LLC
RECRUITING

Houston, Texas, 77089, United States
Rochester Clinical Research
RECRUITING

Rochester, New York, 14609, United States
Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group
RECRUITING

Union City, Georgia, 30291, United States
Sky Integrative Medical Center
RECRUITING

Ridgeland, Mississippi, 39157, United States
Solaris Clinical Research
RECRUITING

Meridian, Idaho, 83646, United States
South Florida Clinical Research
RECRUITING

Margate, Florida, 33063, United States
South Texas Research Institute
RECRUITING

Edinburg, Texas, 78539, United States
Southern California Clinical Research
RECRUITING

Santa Ana, California, 92701, United States
Texas Institute of Cardiology
RECRUITING

McKinney, Texas, 75071, United States
University of Florida Department of Medicine
RECRUITING

Gainesville, Florida, 32610, United States
VIP Trials
RECRUITING

San Antonio, Texas, 78230, United States

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