New hope for Hard-to-Treat prostate cancer: early trial launches

NCT ID NCT04221542

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 16, 2026 · Updated 29 times

Summary

This early-phase study tests a new drug called AMG 509 in people with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. About 479 participants will receive the drug alone or with other treatments.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Asan Medical Center
RECRUITING

Seoul, 138-736, South Korea
Centre Hospitalier Universitaire Vaudois
RECRUITING

Lausanne, 1011, Switzerland
Chris OBrien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Duke University Medical Center Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Fudan University Shanghai Cancer Centre
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Hospital Clinic i Provincial de Barcelona
RECRUITING

Barcelona, Catalonia, 08036, Spain
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Universitari Vall d Hebron
RECRUITING

Barcelona, Catalonia, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital da Luz, SA
RECRUITING

Lisbon, 1500-650, Portugal
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
RECRUITING

Porto, 4200-072, Portugal
Intermountain Medical Center
RECRUITING

Murray, Utah, 84107, United States
Istituto Oncologico della Svizzera Italiana
RECRUITING

Bellinzona, 6500, Switzerland
Kantonsspital Graubuenden
RECRUITING

Chur, 7000, Switzerland
Kantonsspital Sankt Gallen
RECRUITING

Sankt Gallen, 9007, Switzerland
Klinikum rechts der Isar der TUM
RECRUITING

München, 81675, Germany
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
RECRUITING

Taoyuan, 33305, Taiwan
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
MidAmerica Cancer Care
RECRUITING

Merriam, Kansas, 66204, United States
Monash Medical Centre
RECRUITING

Clayton, Victoria, 3168, Australia
Nanjing Drum Tower Hospital
RECRUITING

Nanjing, 210003, China
National Cancer Center Hospital East
RECRUITING

Kashiwa-shi, Chiba, 277-8577, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Oncology Hematology Care Incorporated
RECRUITING

Cincinnati, Ohio, 45242, United States
Peking University First Hospital
RECRUITING

Beijing, Beijing Municipality, 100034, China
Prisma Health Upstate
COMPLETED

Greenville, South Carolina, 29605, United States
Providence Saint Jude Medical Center
RECRUITING

Fullerton, California, 92835, United States
Rocky Mountain Cancer Centers
RECRUITING

Aurora, Colorado, 80012, United States
Sanford Oncology Clinic and Pharmacy
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, 510060, China
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, 325000, China
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tulane Medical Center
COMPLETED

New Orleans, Louisiana, 70112, United States
US Oncology Research Investigational Products Center
RECRUITING

Irving, Texas, 75063, United States
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria
RECRUITING

Lisbon, 1649-035, Portugal
United States Oncology Regulatory Affairs Corporate Office
RECRUITING

Nashville, Tennessee, 37203, United States
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitaetsklinikum Muenster
RECRUITING

Münster, 48149, Germany
University of California San Francisco
RECRUITING

San Francisco, California, 94158, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Virginia Cancer Specialists PC
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States
Yale New Haven Hospital
RECRUITING

New Haven, Connecticut, 06520, United States
Yokohama City University Hospital
RECRUITING

Yokohama, Kanagawa, 236-0004, Japan
Zhejiang Provincial Peoples Hospital
RECRUITING

Hangzhou, Zhejiang, 314408, China

Conditions

Explore the condition pages connected to this study.

PROSTATE CANCER