New hope for men with Hard-to-Treat prostate cancer: drug combo trial launches

NCT ID NCT07213674

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 5 times

Summary

This phase 3 trial is testing whether adding the experimental drug xaluritamig to standard abiraterone helps men with metastatic castration-resistant prostate cancer live longer. About 750 participants who have not yet had chemotherapy will be randomly assigned to receive either the combination or one of several standard treatments. The main goal is to compare overall survival between the groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Xaluritamig (also called AMG 509) plus abiraterone
What this could lead to: If successful, this combination could extend survival for men with advanced prostate cancer that no longer responds to hormone therapy, offering a new treatment option before chemotherapy.
What could go wrong: This is a large phase 3 trial, but the experimental drug is still investigational. It may not improve survival compared to current treatments, and side effects from the combination could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Alexandra Hospital
RECRUITING

Athens, 11528, Greece
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Athens Medical Center S.A - Iatriko Amarousiou
RECRUITING

Marousi, 15125, Greece
Attikon University Hospital
RECRUITING

Athens, 12462, Greece
Austin Health, Austin Hospital
RECRUITING

East Melbourne, Victoria, 3002, Australia
Azienda Ospedaliera Universitaria San Luigi Gonzaga
RECRUITING

Orbassano, 10043, Italy
Azienda Ospedaliera Universitaria di Modena Policlinico
RECRUITING

Modena, 41124, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia
RECRUITING

Foggia, 71122, Italy
Barbara Ann Karmanos Cancer Institute
RECRUITING

Lansing, Michigan, 48910, United States
Bon Secours Cancer Institute at Saint Francis
RECRUITING

Midlothian, Virginia, 23114, United States
CIUSSS de l Estrie CHUS Hopital Fleurimont
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Calvary Mater Newcastle Hospital
RECRUITING

Waratah, New South Wales, 2298, Australia
Centre Antoine Lacassagne
RECRUITING

Nice, 06189, France
Centre Hospitalier Universitaire Dinant Godinne - Universite Catholique de Louvain Namur
RECRUITING

Yvoir, 5530, Belgium
Centre Hospitalier Universitaire Vaudois
RECRUITING

Lausanne, 1011, Switzerland
Centre Hospitalier Universitaire de Bordeaux - Hopital Saint Andre
RECRUITING

Bordeaux, 33075, France
Centre Hospitalier Universitaire de Strasbourg - Hopital de Hautepierre
RECRUITING

Strasbourg, 67000, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, 63011, France
Centre Leon Berard
RECRUITING

Lyon, 69373, France
Centre Regional Francois Baclesse
RECRUITING

Caen, 14076, France
Centre de Recherche du Centre Hospitalier de l Universite de Montreal
RECRUITING

Montreal, Quebec, H2X 0A9, Canada
Charite - Universitaetsmedizin Berlin, Campus Mitte
RECRUITING

Berlin, 10117, Germany
City of Hope Atlanta
RECRUITING

Newnan, Georgia, 30265, United States
City of Hope Cancer Center Phoenix
RECRUITING

Goodyear, Arizona, 85338, United States
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
City of Hope Orange County Lennar Foundation Cancer Center
RECRUITING

Duarte, California, 91010, United States
Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Clinique Victor Hugo - Centre Jean Bernard
RECRUITING

Le Mans, 72000, France
Complexo Hospitalario Universitario A Coruna Hospital Teresa Herrera
RECRUITING

A Coruña, Galicia, 15006, Spain
Dokkyo Medical University Saitama Medical Center
RECRUITING

Koshigaya-shi, Saitama, 343-8555, Japan
European Interbalkan Medical Center
RECRUITING

Thessaloniki, 57001, Greece
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
General Oncological Hospital of Kifisia Oi Agioi Anargyroi
RECRUITING

Kifissia, Athens, 14564, Greece
Groupe Hospitalier Paris Saint Joseph
RECRUITING

Paris, 75014, France
Gustave Roussy
RECRUITING

Villejuif, 94805, France
Guys Hospital
RECRUITING

London, SE1 9RY, United Kingdom
Hartford HealthCare Cancer Institute at Hartford Hospital
RECRUITING

Hartford, Connecticut, 06102, United States
Hematology Oncology Association of Central New York
RECRUITING

East Syracuse, New York, 13057, United States
Henry Dunant Hospital Center
RECRUITING

Athens, 11526, Greece
Hightower Clinical
RECRUITING

Oklahoma City, Oklahoma, 73102, United States
Hirslanden Zurich
RECRUITING

Zurich, 8032, Switzerland
Hopital Europeen Georges Pompidou
RECRUITING

Paris, 75015, France
Hopital Foch
RECRUITING

Suresnes, 92151, France
Hospital Clinic i Provincial de Barcelona
RECRUITING

Barcelona, Catalonia, 08036, Spain
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Clinico Universitario Virgen de la Victoria
RECRUITING

Málaga, Andalusia, 29010, Spain
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, Andalusia, 29011, Spain
Hospital Universitari Vall d Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Lucus Augusti
RECRUITING

Lugo, Galicia, 27003, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital da Luz, SA
RECRUITING

Lisbon, 1500-650, Portugal
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, Catalonia, 08041, Spain
IRCCS Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
IRCCS Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Icon Cancer Care Wesley
RECRUITING

Auchenflower, Queensland, 4066, Australia
Inselspital Bern
RECRUITING

Bern, 3010, Switzerland
Institut Bergonie
RECRUITING

Bordeaux, 33076, France
Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals
RECRUITING

L'Hospitalet de Llobregat, Catalonia, 08908, Spain
Institut Universitaire du Cancer Toulouse Oncopole
RECRUITING

Toulouse, 31059, France
Institut de Cancerologie de Lorraine
RECRUITING

Vandœuvre-lès-Nancy, 54519, France
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
RECRUITING

Porto, 4200-072, Portugal
Johns Hopkins Hospital Sidney Kimmell Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Kagawa University Hospital
RECRUITING

Kita-gun, Kagawa-ken, 761-0793, Japan
Kanazawa University Hospital
RECRUITING

Kanazawa, Ishikawa-ken, 920-8641, Japan
Kantonsspital Sankt Gallen
RECRUITING

Sankt Gallen, 9007, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Kitasato University Hospital
RECRUITING

Sagamihara-shi, Kanagawa, 252-0375, Japan
Kobe University Hospital
RECRUITING

Kobe, Hyōgo, 650-0017, Japan
Krankenhaus der Barmherzigen Brueder Wien
RECRUITING

Vienna, 1020, Austria
Kyushu University Hospital
RECRUITING

Fukuoka, Fukuoka, 812-8582, Japan
Medical Oncology Hematology Consultants Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States
Midwestern Regional Medical Center dba City of Hope Chicago
RECRUITING

Zion, Illinois, 60099, United States
Minnesota Oncology Hematology PA
RECRUITING

Minneapolis, Minnesota, 55404, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Monash Medical Centre
RECRUITING

Clayton, Victoria, 3168, Australia
Nagoya University Hospital
RECRUITING

Nagoya, Aichi-ken, 466-8560, Japan
National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore
National Cheng Kung University Hospital
RECRUITING

Tainan, 70403, Taiwan
National Hospital Organization Shikoku Cancer Center
RECRUITING

Matsuyama, Ehime, 791-0280, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
National University Hospital
RECRUITING

Singapore, 119074, Singapore
Nippon Medical School Hospital
RECRUITING

Bunkyo-ku, Tokyo, 113-8603, Japan
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40207, United States
Oncology Hematology Care Incorporated
RECRUITING

Cincinnati, Ohio, 45242, United States
Ordensklinikum Linz Elisabethinen
RECRUITING

Linz, 4020, Austria
Oregon Oncology Specialists
RECRUITING

Salem, Oregon, 97301, United States
Osaka International Cancer Institute
RECRUITING

Osaka, Osaka, 541-8567, Japan
Ospedale Pederzoli Casa di Cura Privata
RECRUITING

Peschiera del Garda, 37019, Italy
Ospedale Santa Chiara Azienda Sanitaria Universitaria Integrata del Trentino
RECRUITING

Trento, 38122, Italy
Providence Saint Johns Health Center
RECRUITING

Santa Monica, California, 90404, United States
Providence Saint Jude Medical Center
RECRUITING

Fullerton, California, 92835, United States
Renovatio Clinical
RECRUITING

Houston, Texas, 77030, United States
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80218, United States
Royal Marsden Hospital
RECRUITING

Sutton, SM2 5PT, United Kingdom
Saitama Medical University International Medical Center
TERMINATED

Hidaka-shi, Saitama, 350-1298, Japan
Sarah Cannon Research Institute Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute UK
RECRUITING

London, W1G 6AD, United Kingdom
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Sir Mortimer B Davis - Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
South Texas Accelerated Research Therapeutics - Carolinas
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, 40705, Taiwan
Tan Tock Seng Hospital
RECRUITING

Singapore, 308433, Singapore
Tasman Oncology Research
RECRUITING

Southport, Queensland, 4215, Australia
Texas Oncology Northeast Texas
RECRUITING

Tyler, Texas, 75702, United States
The Cancer institute Hospital of Japanese Foundation for Cancer Research
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
The Center for Cancer and Blood Disorders
RECRUITING

Arlington, Texas, 76012, United States
The Jikei University Hospital
RECRUITING

Minato-ku, Tokyo, 105-8471, Japan
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
The University of Osaka Hospital
RECRUITING

Suita-shi, Osaka, 565-0871, Japan
Toyama University Hospital
RECRUITING

Toyama, Toyama, 930-0194, Japan
US Oncology Research Investigational Products Center
RECRUITING

Tyler, Texas, 75702, United States
Unidade Local de Saude de Gaia-Espinho, EPE
RECRUITING

Vila Nova de Gaia, 4430-502, Portugal
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria
RECRUITING

Lisbon, 1649-035, Portugal
Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao
RECRUITING

Porto, 4200-319, Portugal
Uniklinikum Erlangen
RECRUITING

Erlangen, 91054, Germany
United States Oncology Regulatory Affairs Corporate Office
RECRUITING

Nashville, Tennessee, 37203, United States
Universitaetsklinikum Allgemeines Krankenhaus Wien
RECRUITING

Vienna, 1090, Austria
Universitaetsklinikum Bonn
RECRUITING

Bonn, 53127, Germany
Universitaetsklinikum Dresden
RECRUITING

Dresden, 01307, Germany
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Hamburg Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitaetsklinikum Jena
RECRUITING

Jena, 07747, Germany
Universitaetsklinikum Sankt Poelten
RECRUITING

Sankt Pölten, 3100, Austria
Universitaetsklinikum Schleswig-Holstein - Kiel
RECRUITING

Kiel, 24105, Germany
Universitaetsklinikum Ulm
RECRUITING

Ulm, 89081, Germany
Universitaetsklinikum Wuerzburg
RECRUITING

Würzburg, 97080, Germany
Universitair Medisch Centrum Groningen
RECRUITING

Groningen, 9713 GZ, Netherlands
Universitair Ziekenhuis Gent
RECRUITING

Ghent, 9000, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
Universite Catholique de Louvain Cliniques Universitaires Saint Luc
RECRUITING

Brussels, 1200, Belgium
University General Hospital of Alexandroupoli
RECRUITING

Alexandroupoli, 68100, Greece
University Hospital of Heraklion
RECRUITING

Heraklion - Crete, 71500, Greece
University of Arizona Cancer Center
RECRUITING

Tucson, Arizona, 85724, United States
University of California Irvine
RECRUITING

Orange, California, 92868, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94158, United States
University of Illinois Chicago
RECRUITING

Chicago, Illinois, 60612, United States
University of Kansas Medical Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Louisville Health - James Graham Brown Cancer Center
RECRUITING

Louisville, Kentucky, 40202, United States
University of Maryland Greenebaum Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Minnesota Medical Center Fairview
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22903, United States
Virginia Cancer Specialists PC
RECRUITING

Leesburg, Virginia, 20176, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States

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