New pill targets Hard-to-Treat KRAS cancers in first human trial

NCT ID NCT07094113

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a new oral drug called AMG 410, alone or with other medicines, in adults with advanced solid tumors that have KRAS gene changes. The study aims to find a safe dose and check for side effects. About 434 participants will take part across multiple dose levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AMG 410 (oral tablet), pembrolizumab (IV infusion), panitumumab (IV infusion)

What this could lead to

If successful, this could point toward a new treatment option for people with advanced cancers that have KRAS mutations, especially those who have run out of standard therapies.

What could go wrong

This is a very early Phase 1 trial, so the drug may not work or may cause serious side effects. The study is primarily looking at safety and dosing, not yet proving effectiveness.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colorectal neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KRAS ALTERED ADVANCED OR METASTATIC SOLID TUMORS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Aichi Cancer Center
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Azienda Ospedaliero Universitaria Pisana
RECRUITING

Pisa, 56126, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, 20162, Italy
Beijing Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, 100142, China
Centre Leon Berard
RECRUITING

Lyon, 69008, France
Centro Ricerche Cliniche Di Verona Societa responsabilita limitata
RECRUITING

Verona, 37134, Italy
Chris OBrien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Gustave Roussy
RECRUITING

Villejuif, 94805, France
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Jinan Central Hospital
RECRUITING

Jinan, Shandong, 250013, China
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa-shi, Chiba, 277-8577, Japan
Next Oncology
RECRUITING

San Antonio, Texas, 78229, United States
Next Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 1Z5, Canada
Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Royal Marsden Hospital
RECRUITING

Sutton, SM2 5PT, United Kingdom
Sarah Cannon Research Institute Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute UK
RECRUITING

London, W1G 6AD, United Kingdom
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Sir Mortimer B Davis - Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Siteman Cancer Center - Washington University
RECRUITING

St Louis, Missouri, 63110, United States
The Queen Elizabeth Hospital
RECRUITING

Woodville South, South Australia, 5011, Australia
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitair Medisch Centrum Utrecht
RECRUITING

Utrecht, 3584 CX, Netherlands
Universitair Ziekenhuis Antwerpen
RECRUITING

Edegem, 2650, Belgium
Universitair Ziekenhuis Gent
RECRUITING

Ghent, 9000, Belgium
University of California Los Angeles
RECRUITING

Los Angeles, California, 90095, United States