New hope for kids with painful mouth sores: drug trial launches

NCT ID NCT04528082

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study tests whether the drug apremilast (Otezla) can reduce painful mouth ulcers in children aged 2 to 17 with Behçet's disease. About 60 participants will receive either apremilast or a placebo for 12 weeks to see if the drug works better than a dummy pill. The goal is to help kids have fewer and less painful ulcers, improving their quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: apremilast (Otezla)
What this could lead to: If it works, this could give children with Behçet's disease a new treatment option to reduce painful mouth ulcers and improve daily life.
What could go wrong: This is still a clinical trial with only 60 participants, so results may not apply to everyone. Apremilast can cause side effects like nausea or diarrhea, and it may not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Behcet disease Oral Ulcer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BEHÇET DISEASE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Agia Sofia Children Hospital
RECRUITING

Athens, 11527, Greece
Alder Hey Childrens Hospital
RECRUITING

Liverpool, L12 2AP, United Kingdom
Attikon University General Hospital
RECRUITING

Athens, 12462, Greece
Azienda Socio Sanitaria Territoriale Centro Specialistico Ortopedico Traumatologico Gaetano Pini
TERMINATED

Milan, 20122, Italy
Birmingham Childrens Hospital
TERMINATED

Birmingham, B4 6NH, United Kingdom
Centre Hospitalier Universitaire Vaudois
TERMINATED

Lausanne, 1011, Switzerland
Dokuz Eylul Universitesi Tip Fakultesi Hastanesi
TERMINATED

Izmir, 35330, Turkey (Türkiye)
Erciyes Universitesi Tip Fakultesi Hastanesi
RECRUITING

Kayseri, 38030, Turkey (Türkiye)
General Hospital of Thessaloniki Ippokrateio
RECRUITING

Thessaloniki, 54642, Greece
Hacettepe Universitesi Tip Fakultesi Hastanesi
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Hopital Necker Enfants Malades
TERMINATED

Paris, 75015, France
Hopital Robert Debre
RECRUITING

Paris, 75019, France
Hospices Civils de Lyon Hopital Femme Mere Enfant
RECRUITING

Bron, 69677, France
Hospital Sant Joan de Deu
RECRUITING

Esplugues de Llobregat, Catalonia, 08950, Spain
Hospital Universitari Vall d Hebron
RECRUITING

Barcelona, Catalonia, 08035, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, Valencia, 46026, Spain
Hospital Universitario La Paz
TERMINATED

Madrid, 28046, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, Andalusia, 41013, Spain
IRCCS Istituto Giannina Gaslini
RECRUITING

Genova, 16147, Italy
IRCCS Ospedale Pediatrico Bambino Gesu
RECRUITING

Roma, 00165, Italy
Istanbul Universitesi Cerrahpasa Tip Fakultesi
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Istanbul Universitesi Istanbul Tip Fakultesi Hastanesi
RECRUITING

Istanbul, 34093, Turkey (Türkiye)
John Radcliffe Hospital
RECRUITING

Oxford, OX3 7LD, United Kingdom
Meir Medical Center
RECRUITING

Kfar Saba, 4428164, Israel
Ospedale Santissima Annunziata
TERMINATED

Chieti, 66100, Italy
Umraniye Egitim ve Arastirma Hastanesi
RECRUITING

Istanbul, 34764, Turkey (Türkiye)

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