ASTHMA

This study is testing whether the drug dupilumab can improve how well the lungs clear mucus in people with moderate to severe asthma. About 30 adults will receive either dupilumab or a placebo for 12 weeks. Researchers will use a special imaging technique to measure mucus clearan…

This study tests whether a newer extrafine inhaler (Trimbow) works better than a standard one (Trelegy) for people with moderate to severe asthma that is not well controlled. Researchers will use special MRI scans to see how well the medicine reaches the lungs and measure breathi…

This study is testing whether a special education program called 'Asthma School' can help adults with asthma have fewer flare-ups, emergency room visits, and hospital stays over a year. The program teaches patients how to better manage their condition and follow their treatment p…

This study tests an investigational drug called tezepelumab in children aged 5 to 12 with severe asthma that is not well controlled by current treatments. The goal is to see if it can reduce serious asthma attacks and improve lung function. About 231 children will receive either …

This study tests if a combination inhaler (budesonide/albuterol) works better than a standard albuterol inhaler for teens with asthma. About 440 adolescents aged 12 to 18 who have had a severe asthma attack in the past year will use the inhaler as needed for 52 weeks. The goal is…

This study tests an experimental drug called tozorakimab in adults whose asthma is not well controlled despite using medium-to-high dose inhaled steroids. About 540 participants will receive either the drug or a placebo as a shot, and researchers will track how many severe asthma…

This study tests a new drug called SHR-1905 for adults with severe asthma that is not well controlled by current treatments. The goal is to see if it can reduce asthma attacks and improve breathing. About 408 participants will receive either the drug or a placebo, and researchers…

This study is testing a smartphone app called ASTHMAXcel Voice that helps people with asthma track their symptoms and voice changes. About 200 English-speaking adults with persistent asthma who own a smartphone will either use the app or receive usual care. The goal is to see if …

This study tests two approaches to reduce asthma attacks: using inhaled steroids as a rescue treatment (called R-ICS) and taking the antibiotic azithromycin to prevent attacks. About 3,200 people with asthma aged 13-75 will try one or both methods. The goal is to find which strat…

This study tests an injectable drug called depemokimab in 150 adults with severe asthma caused by a type of inflammation linked to high levels of certain white blood cells (eosinophils). The goal is to see if the drug can reduce mucus plugs and airway thickening in the lungs over…

This study tests an injectable drug called benralizumab in 200 children aged 6 to 17 with severe eosinophilic asthma that is not well controlled by standard inhalers. The goal is to see if it can reduce asthma attacks and improve daily symptoms. Participants must have a history o…

This study tests a program called BREATHE that helps Black adults with uncontrolled asthma work together with their doctors to make better treatment decisions. The goal is to improve asthma control and quality of life. About 400 participants will take part at community health cen…

This study tests a new injectable drug called lunsekimig for adults with asthma that is not well-controlled but who are not yet eligible for current biologic treatments. The goal is to see if it can reduce asthma attacks and improve breathing over about a year. Around 1,147 parti…

This study looks at whether a new digital inhaler (Whizz spacer) helps children aged 5 to 16 with asthma use their medication more consistently and control their symptoms better, compared to a standard inhaler. Researchers will also search for biomarkers in blood and breath to im…

This study compares a new version of an asthma inhaler that uses a more environmentally friendly propellant to the current inhaler. Researchers want to make sure both versions work equally well for people with mild to moderate asthma. About 780 adults will participate in this pha…

This study watches 600 adults with asthma who are prescribed the Enerzair inhaler as part of their normal care. Over 24 weeks, doctors track side effects and how well the medicine controls asthma symptoms. The goal is to confirm the inhaler works safely in everyday use.

This study tests a mobile health program to help African American young adults (ages 18-30) better control their asthma. Participants use a smartphone app, video calls with an asthma nurse, text reminders, and activity tracking. The goal is to improve asthma symptoms and quality …

This study looks at whether placing a temporary balloon in the stomach, along with diet and exercise, can improve asthma control in obese adults whose asthma is not well managed by standard inhalers. About 84 participants will be randomly assigned to receive the balloon plus life…

This study looks at how well tezepelumab works for adults with chronic sinusitis and nasal polyps (with or without asthma). About 110 people will be followed for up to a year to see if their nasal polyps shrink and congestion improves. The drug is already approved, and this resea…

This study tests whether adding glycopyrronium to standard asthma medication improves lung function in children aged 4 to 12. About 69 kids with asthma will receive two different doses of glycopyrronium or a placebo, in addition to their usual treatment. The main goal is to see i…

This study tests whether a new inhaler that combines fluticasone (an anti-inflammatory steroid) and albuterol (a rescue bronchodilator) can prevent severe asthma attacks better than albuterol alone. About 2,700 adults with asthma who have had at least one severe attack in the pas…

This study tests whether weekly phone calls with education, relaxation techniques, and motivational interviewing can help adults with asthma who are anxious about using their steroid inhaler. 216 participants will be split into two groups: one gets the extra phone support, the ot…

This study tests a new inhaler that combines two common asthma medicines (fluticasone and albuterol) to see if it works better than each medicine alone or a placebo. About 724 people aged 12 and older with asthma will use the inhaler four times daily for four weeks. The goal is t…

This study looks at how well a once-daily triple inhaler (Trimbow) works for adults with uncontrolled asthma in everyday settings. About 200 people will use the inhaler for 6 months, and researchers will track changes in asthma control and medication adherence. The goal is to see…

This study tests whether treating suddenly ill adults at home is as safe and effective as hospital care. About 3,000 participants with conditions like infections, heart failure, or COPD will receive hospital-level care at home. The goal is to see if home care can lower costs and …

This study tests two doses of an inhaled drug called glycopyrronium in 42 children aged 6 to 12 with moderate to severe asthma. The goal is to see if it improves lung function and to find the right dose for a future combination medicine. Participants will receive the drug or a pl…

This study tests an experimental medicine called PF-07275315 for adults with moderate-to-severe asthma that is not well controlled. Participants will receive either the study drug or a placebo as injections over 12 weeks. The goal is to see if the drug improves lung function and …

This study tests whether escitalopram, a common antidepressant, can reduce the number of severe asthma attacks in adults with moderate to severe asthma who have had at least three attacks in the past year. About 105 participants will receive either escitalopram or a placebo, and …

This study looks at how well Airsupra works compared to albuterol for preventing severe asthma attacks in real-world settings. About 4,000 people with asthma who use rescue inhalers will be followed for 12 months. Researchers will track asthma attacks, medication use, and patient…

This study tests a new drug called brenipatide in adults whose moderate-to-severe asthma is not well controlled. About 531 participants will receive either brenipatide or a placebo for 52 weeks to see if it reduces asthma attacks and improves breathing. The goal is to find a bett…

This study looks at whether a smart inhaler cap and phone app can help adults with poorly controlled asthma use their inhaler correctly and take their medication as prescribed. About 60 participants will use the smart system for one year while continuing their usual asthma treatm…

This study tests whether giving a rescue inhaler called Airsupra to adults in the emergency department can reduce asthma flare-ups and improve control over the next 3 months. About 1,860 participants aged 18–54 with acute asthma will be randomly assigned to receive Airsupra or us…

This study looks at 250 adults with asthma that is not well controlled by their current medium-dose inhaler. Researchers want to see if adding a drug called dupilumab to the usual inhaler works better than simply increasing the inhaler dose. The goal is to reduce severe asthma at…

This study tests an injectable medicine called dupilumab in children aged 2 to under 6 years whose asthma or wheezing is not well controlled with standard inhalers. The goal is to see if it can reduce severe asthma attacks and improve breathing safety over a year. About 90 childr…

This study tests whether metformin, a common diabetes drug, can improve asthma control in overweight or obese adults whose asthma is not well-controlled by their current inhalers. About 100 participants will take metformin or a placebo for 24 weeks and have their asthma symptoms,…

This study looks at whether extra support from an asthma navigator can help children aged 4 to 12 avoid another hospital stay after being treated for an asthma attack. About 340 families will take part, with half getting the usual care and half also getting a navigator to help ma…

This study compares two inhalers, PT027 and PT007, used as needed in Chinese adults with asthma. The goal is to see if PT027 reduces the risk of severe asthma attacks better than PT007. About 790 participants with a history of at least one severe attack in the past year will be f…

This study tests whether a three-drug inhaler (FF/UMEC/VI) works better than a two-drug inhaler (FF/VI) for teens aged 12-17 whose asthma is not well controlled with their current medication. About 292 participants will use one of the two inhalers daily for 24 weeks. The main goa…

This study tests whether semaglutide, a drug already approved for diabetes and weight loss, can improve asthma control in adults with obesity who still have symptoms despite using inhaled steroids. About 100 participants will receive either semaglutide or a placebo for up to 24 w…

This study tests whether connecting youth (ages 12-25) to community programs rooted in Native Hawaiian culture can improve their mental and chronic health. Participants will take part in cultural activities and complete surveys about their well-being. The goal is to see if this a…

This study tests an experimental oral drug, ENV-294, in 50 adults with moderate-to-severe asthma who already use standard inhalers. Participants take either the drug or a placebo once daily for 12 weeks. Researchers will check safety, drug levels, and whether the pill improves as…

This study tests a new drug called 610 in Chinese adults with severe eosinophilic asthma. The goal is to see if it can reduce the number of serious asthma attacks over one year. Participants will receive either the drug or a placebo, and researchers will monitor their safety and …

This study compares a new combination inhaler (QMF149) to a standard asthma inhaler (budesonide) in 200 children aged 6 to 12 with asthma. Each child will try both treatments for 12 weeks to see which one improves lung function and symptom control more. The goal is to find a more…

This study looks at the long-term safety and effectiveness of a drug called lunsekimig for adults with asthma. Participants who finished a previous study can join this one and receive the drug for up to 96 weeks. The goal is to see if the drug continues to help control asthma and…

This study tests whether a single inhaler that both relieves symptoms and prevents asthma attacks works better than the standard approach of using separate inhalers. About 1,000 children and teens aged 6-18 with asthma will be followed for one year. The goal is to see if the comb…

This study looks at whether two easy, non-invasive tests—a breath test (FeNO) and a blood test (eosinophils)—can accurately diagnose asthma in children aged 6 to 17. Currently, diagnosing asthma often requires complex hospital-based tests. The goal is to see if these simpler test…

This study tests if a smartphone app can listen to your breathing and detect lung problems like asthma, COPD, or cystic fibrosis. Researchers will compare the app's results to standard breathing tests. If successful, this could make lung health checks easier and more accessible, …

This study aims to see if two easy breathing tests—oscillometry and FeNO—can help primary care doctors accurately diagnose asthma and COPD without needing complex equipment. About 600 adults with symptoms like wheezing or shortness of breath will take these tests at their local c…

This study tests a device called fenoTRACK that measures a gas in your breath (FeNO) to check airway inflammation. It involves 160 adults and children with asthma, some with uncontrolled symptoms and some with controlled asthma. The goal is to see if the device can accurately tra…

This study looks at whether measuring inflammation in the breath and blood can help prioritize who gets lung tests first when asthma is suspected. Researchers will include 1,500 people aged 6 and older who were referred by their primary care doctor. The goal is to see if this app…

This study tests a small wearable device that listens to lung sounds to detect wheezing, a common sign of asthma and other breathing problems. About 160 children and adults with asthma will wear the device while a doctor also listens to their lungs. The goal is to see if the devi…

This study is testing whether giving pregnant women extra fish oil (higher than usual doses) can lower the chance of their child developing asthma or persistent wheezing in the first three years of life. The researchers are enrolling 2,000 pregnant women in Denmark who have low b…

This study tests whether giving pregnant women higher doses of vitamin D than currently recommended can prevent asthma and persistent wheezing in their children during the first three years of life. Researchers will enroll 2,000 pregnant women in Denmark and follow their children…

This study looks at whether combining neck exercises with special breathing techniques can improve lung function and chest movement in adults with asthma who also have poor posture. 22 people will take part in a 4-week program. The goal is to find a simple, drug-free way to help …

This early-stage study is testing a new drug called AMG 691 to see if it is safe and how the body processes it. The study includes healthy volunteers and people with mild-to-moderate asthma. Participants will receive either the drug or a placebo, and researchers will monitor for …

This study looks at whether a new propellant (HFA-152a) in salbutamol inhalers works as well as the current one (HFA-134a) for people with mild asthma. About 84 adults aged 18 to 65 will take single doses of the inhaler and have their lung function measured. The goal is to make s…

This study tests a device that coaches people with COPD or asthma on how to use their inhalers correctly. About 140 adults will either use the device or get brief standard training. After 6 weeks, researchers check if the device improves inhaler technique and reduces hospital vis…

This study tests whether a new way of talking to teens about their asthma can improve their quality of life. About 98 teenagers aged 12-18 with asthma will be randomly assigned to either a special consultation focused on their confidence in managing asthma, or a standard appointm…

This study tests an inhaled medicine called ARO-RAGE in 36 adults with mild asthma. The goal is to see if it can improve small airway function after breathing in an allergen. Participants will receive either the drug or a placebo and have their lung function measured over time.

This study tests whether energy-saving exercises or circuit training better reduce shortness of breath and improve daily life in people with asthma. Researchers will measure walking ability, breathing difficulty, and quality of life in 32 adults with mild-to-moderate asthma. The …

This study is testing a serious video game designed to improve emotional well-being in adolescents aged 12 to 16, both with and without chronic conditions like type 1 diabetes, asthma, and allergies. The game uses artificial intelligence to adapt activities and feedback to each t…

This study tests a device called the Lung Master to see if it can help people with breathing problems like COPD or asthma increase their lung capacity. Twenty adults (ages 19-35 or over 65) will use the device daily at home for a month and have their lung function measured before…

This study tests whether an online therapy program can help children aged 8-17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. About 30 children and their parent…

This early-stage study tests a new drug called IBI3002 in adults with asthma. The main goal is to check if multiple doses are safe and tolerable. About 12 to 27 participants will receive either the drug or a placebo by injection. The study lasts about 24 weeks total, including sc…

This study looks at whether giving magnesium through an IV early on can reduce breathing trouble in children aged 2 to 17 who still have moderate-to-severe asthma after standard emergency treatment. About 192 children will be randomly assigned to receive either magnesium or a pla…

This study tests whether alternate nostril breathing exercises or using an incentive spirometer (a device that helps you take deep breaths) works better for improving lung function in people with mild to moderate asthma. Researchers will measure how much air you can exhale and yo…

This study looks at whether adding physical exercise to a restricted diet can improve lung function and weight in women who have both PCOS and asthma. Researchers will measure breathing tests and body mass index in 40 obese women. The goal is to see if combining exercise with die…

This study looks at whether using a CPAP machine at night can improve asthma control in adults with severe, hard-to-control asthma and obstructive sleep apnea. Researchers will measure asthma symptoms and lung function in 138 participants over time. The goal is to see if treating…

This study looks at whether tongue images and pulse wave data can help doctors diagnose and track asthma in children aged 5 to 18. Researchers will collect these non-invasive measurements during routine check-ups and compare them with standard lung function tests. The goal is to …

This study looks at how genes are linked to different types and severities of asthma in Chinese people. Researchers will collect DNA and health data from 2,000 asthma patients to find common genetic variants. The goal is to better understand asthma in this population, not to test…

This study aims to understand how mucus buildup in the airways affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and other tests to measure mucus in 240 adults and 50 children with these conditions, plus 100 healthy volunteers. The goal is to find…

This study aims to find out how many adults with mild-to-moderate asthma in Thailand experience remission and what factors are linked to it. Researchers will ask participants about their asthma symptoms, do breathing tests, and take a blood sample. No treatment is given; the goal…

This study is testing a new type of MRI that uses a special gas (xenon) to take detailed pictures of lung function. It will include 260 healthy volunteers and people with various lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this imaging method can b…

This study is a global registry that collects health information from adults with severe asthma. The goal is to track how patients respond to treatments and understand the disease better. By gathering data from many people, researchers hope to improve care and develop better trea…

This study tests two new types of lung MRI (using special gases) to see if they can better show lung problems in people with cystic fibrosis or asthma. About 30 people aged 8 and older, including healthy volunteers, will have scans to compare lung structure and function. The goal…

This study looks at cells from the airways of 24 adults (some with asthma, some without) to understand why mucus is overproduced in asthma. Researchers will compare gene activity in these cells using advanced sequencing. The goal is to learn more about asthma, not to test a new t…

This study aims to find out how common asthma and COPD are among workers in an industrial zone in Thailand. About 310 workers aged 18 and older will fill out a questionnaire about breathing problems and take a lung function test. The results will help understand the impact of wor…

This study follows 500 adults with asthma in Hong Kong who are on step 4 or 5 of standard treatment (medium-to-high dose inhalers or biologics). Over 2 years, researchers will check how well their asthma is controlled and how often they have flare-ups or hospital stays. The goal …

This study is collecting detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. The goal is to identify different disease subtypes and shared features, which could lead to more personaliz…

This study looks at what causes airway inflammation in people with allergic asthma. Researchers will expose participants to allergens and measure how inflammatory cells move into the airways. The goal is to better understand asthma, not to test a new treatment. About 313 adults w…

This study examines lung tissue from 120 adults (ages 18-70) with and without asthma to measure levels of two proteins, ezrin and Pip5k1α, in airway smooth muscle. The goal is to understand how these proteins change in asthma, which could lead to new treatment approaches. Partici…

This study is observing 355 adults with asthma in China to learn about their symptoms, treatments, and biological markers. The goal is to identify different types of asthma to help develop more personalized treatment strategies in the future. Participants will undergo lung functi…

This study looks at how bacteria and viruses living in the airways of adults with asthma are linked to different types and severities of the disease. Researchers will collect samples from 140 adults to understand these connections. The goal is to find new ways to prevent or treat…

This study tests whether computer-based alerts in the electronic health record can help doctors avoid prescribing antibiotics when they aren't needed for children with lower respiratory tract infections like pneumonia, bronchiolitis, or asthma flare-ups. Most of these infections …

This study looks at the bacteria living in the airways of infants under 2 years old with severe asthma. Researchers want to understand how these bacteria differ from normal and how they relate to the immune system. The goal is to find new ways to treat severe asthma in babies. Th…

This study aims to describe the characteristics, treatment burden, and quality of life of 2,500 people with asthma across different severity levels. It includes a one-time assessment and a follow-up to track changes over time. No new treatments are tested; the goal is to gather r…

This study looks at how two different inhalers deliver asthma medicine into the bodies of children aged 4 to 12. The goal is to compare the amount of drug absorbed and check for safety. About 12 children with stable asthma will take part. The results will help doctors understand …

This study uses special lung scans to see how common asthma medications change airflow and blood flow in the lungs. About 40 adults with asthma will take their usual inhaled steroids and a fast-acting rescue inhaler, then get scanned. The goal is to better understand how these me…

This observational study aims to find specific chemical markers (metabolites) in the blood and urine of children aged 12-17 with asthma that could signal an asthma attack. Researchers will analyze samples from 100 children with mild, moderate, and severe asthma who are already re…

This study is testing a wearable device called C-mo System that can automatically detect and describe coughs. 300 people aged 2 and older with cough-related conditions like asthma or COPD will wear the device for 24 hours. The goal is to see how well the device can identify cough…

This study looks at why some people with asthma don't get better with standard inhaled medications. Researchers will use MRI and CT scans to see if blocked or narrowed airways prevent the medicine from reaching the right spots in the lungs. The goal is to understand if these stru…

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers want to see if a specific group of athletes with breathing limitations might benefit from the drug. The study involves 64 healthy,…

This study looks at how a person's genes and their environment (like pollution, diet, and lifestyle) work together to cause common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires and genetic data from 25,000 adults to build a…

This study looks back at medical records of 360 adults in Hong Kong with severe asthma who received biologic therapy. Researchers want to understand which biologics are used, how well they control asthma, and if they reduce flare-ups. The goal is to see how these treatments work …

This study looks at whether a simple breathing test called impulse oscillometry (IOS) can better track asthma control than standard tests. Fifty adults with asthma who are changing their maintenance medication will take lung function tests and questionnaires at the start and agai…

This study follows 6,000 children in Switzerland who have breathing issues like wheezing, coughing, or trouble breathing during exercise. Researchers collect information from doctor visits and family questionnaires to learn more about these problems and how to diagnose and treat …

This study looks at how airway inflammation from asthma might change brain activity and relate to feelings of depression or anxiety. Over three visits, 100 adults (with and without asthma) will answer questionnaires, do computer tasks, give blood and sputum samples, and have brai…

This study looks at how genes play a role in lung diseases like cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will analyze DNA from up to 3,500 people, including healthy volunteers, to find genetic differences linked to lung problems. A small optional part of the s…

This study aims to see if people with allergic asthma and those with eosinophilic asthma have different levels of breathing problems, symptoms, and frailty. Researchers will measure lung function, breathlessness, fatigue, and quality of life in 60 adults aged 35-75. The goal is t…

This study looks at how indoor and outdoor air pollution affects people with asthma. Researchers will place sensors in 30 patients' homes to measure pollutants like fine particles and chemicals. The goal is to see if higher pollution levels are linked to more asthma attacks. Part…

This study follows 1,000 people with eczema and related allergies to learn why some get better and others don't. Researchers will collect health data and samples to find clues that predict remission. The goal is to develop better, personalized treatments for these chronic skin an…

This study aims to find people who have asthma or COPD but don't know it yet. Participants will complete an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their primary care doctor or usual ca…

This study follows 400 nonsmoking adults aged 18–60 with moderate-to-severe asthma for up to 5 years. Researchers collect blood, urine, stool, dust, saliva, and lung samples at regular visits to see how bacteria and other environmental factors affect asthma symptoms and flare-ups…

This study aims to see if a Turkish version of the Brompton Breathing Pattern Assessment Tool (BPAT) is a valid and reliable way to measure breathing patterns in people with asthma. Researchers will enroll 100 Turkish-speaking adults with severe asthma and compare the tool's resu…

This study looks at how the body processes high doses of the steroid prednisolone in people with inflammatory diseases like thyroid eye disease, asthma, and vasculitis. Researchers will measure drug levels in the blood over time to compare short-term and long-term use. The goal i…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…

This study looks at how well the diaphragm works in 800 people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. Participants will do walking and sitting tests to measure br…

This study looks at how fungi found in homes and the environment affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect sputum, dust, and air samples from 125 adults aged 18-80 to measure fungal exposure and lung fu…

This study collects additional medical records from people who previously participated in asthma research. Researchers will gather up to 10 years of past and future health data from electronic records and a one-time questionnaire. The goal is to better understand how asthma devel…