New combo inhaler aims to cut severe asthma attacks in half

NCT ID NCT06471257

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This phase 3 study tests whether an inhaler combining budesonide (a steroid) and albuterol (a rescue drug) works better than albuterol alone for preventing severe asthma attacks. About 790 Chinese adults with asthma who have had at least one severe attack in the past year will use the inhaler as needed for 24 to 52 weeks. The main goal is to see if the combo inhaler delays the first severe attack.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Budesonide/Albuterol inhaler (PT027)
What this could lead to: If successful, this could provide a more effective as-needed treatment for asthma that reduces the risk of severe attacks compared to using albuterol alone.
What could go wrong: This is a phase 3 trial, but results may not apply to all asthma patients. The study only includes Chinese adults, and the benefit over standard care may be modest. Side effects from the added steroid are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

Locations

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Baotou, 014010, China
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Baotou, 14010, China
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Beijing, 100020, China
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Beijing, 100029, China
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Beijing, 100039, China
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Beijing, 100191, China
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Changchun, 130021, China
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Changchun, 130041, China
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Changsha, 410005, China
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Changsha, 410015, China
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Chengdu, 610000, China
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Chengdu, 610021, China
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Chengdu, 610041, China
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Chengdu, 610072, China
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Chengdu, 610500, China
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Chizhou, 247099, China
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Chongqing, 400010, China
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Chongqing, 400037, China
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Chongqing, 401320, China
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Dazhou, 635000, China
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Deyang, 618000, China
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Ganzhou, 341099, China
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Guangyuan, 628000, China
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Guangzhou, 510000, China
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Guangzhou, 510080, China
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Guangzhou, 510080, China
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Guangzhou, 510145, China
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Guangzhou, 510163, China
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Guangzhou, 510317, China
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Haikou, 570208, China
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Hangzhou, 310006, China
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Hangzhou, 310009, China
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Hefei, 133500, China
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Hefei, 230061, China
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Hefei, 230601, China
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Heifei, 230011, China
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Hohhot, 010017, China
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Hohhot, 010050, China
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Huizhou, 516001, China
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Huizhou, 516002, China
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Jinan, 250001, China
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Jinhua, China
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Jining, 272029, China
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Kunming, 650032, China
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Lanzhou, 730000, China
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Linhai, 317000, China
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Luoyang, 471000, China
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Luzhou, 646000, China
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Luzhou, 646000, China
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Mianyang, 621000, China
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Nanchang, 330006, China
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Nanchong, 637000, China
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Nanjing, 210009, China
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Nanjing, 210012, China
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Nantong, 226001, China
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Ningbo, 315010, China
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Panjin, 124009, China
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Panzhihua, 617099, China
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Pingxiang, 337055, China
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Qingdao, 266011, China
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Rui’an, 325200, China
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Sanya, 572000, China
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Shanghai, 200032, China
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Shanghai, 200080, China
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Shanghai, 201199, China
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Shenyang, 110004, China
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Shenyang, 110032, China
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Shenzhen, 518020, China
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Shenzhen, 518036, China
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Shijiazhuang, 054001, China
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Shijiazhuang, 50051, China
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Suining, 629000, China
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Taiyuan, 030001, China
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Taiyuan, 030032, China
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Tianjin, 300050, China
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Ürümqi, 830054, China
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Wenzhou, 325000, China
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Wenzhou, 325027, China
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Wuhan, 430030, China
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ACTIVE_NOT_RECRUITING

Wuhan, 430060, China
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Wuhu, 241000, China
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Xi'an, 710006, China
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Xiamen, 361003, China
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Xintai, 54031, China
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Xinxiang, 453002, China
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Xuzhou, 221000, China
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Xuzhou, 221009, China
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Yangzhou, 225003, China
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Yibin, 610500, China
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Yinchuan, 750001, China
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Yinchuan, 750004, China
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Yueyang, 414000, China
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Yuhuan, 317600, China
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Zhangzhou, 363099, China
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Zhengzhou, 450003, China
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Zhengzhou, 450052, China
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Zhuhai, 519000, China
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Zhuji, 311899, China
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Zibo, 255036, China
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WITHDRAWN

Zigong, 643000, China
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Zunyi, 563100, China
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ACTIVE_NOT_RECRUITING

Hong Kong, 999077, Hong Kong

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