Can dupilumab help lungs clear mucus better in asthma?

NCT ID NCT04743791

Recruiting now Disease control Sponsor: Sally E. Wenzel MD Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study is testing whether the drug dupilumab can improve how well the lungs clear mucus in people with moderate-to-severe asthma. Thirty adults will receive either dupilumab or a placebo for 12 weeks. Researchers will measure mucus clearance using a special imaging technique, along with lung function and asthma control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dupilumab (a biologic drug given as an injection)
What this could lead to: If successful, this could show that dupilumab improves the lungs' ability to clear mucus, pointing to a better way to control asthma symptoms.
What could go wrong: This is a small, early-phase study (30 people) focused on a specific lung measurement, not on long-term outcomes. It may not lead to new treatments or apply to all asthma patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

Locations

The University of Pittsburgh Asthma Institute at UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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