ASTHMA

This study tested whether adding the experimental drug RPT193 to standard asthma inhalers could help adults whose asthma isn't fully controlled. Participants had moderate-to-severe asthma and continued using their regular inhalers while receiving either RPT193 or a placebo for 14…

This early-stage study tested an inhaled drug called ARO-MUC5AC, designed to reduce harmful mucus in the lungs. It aimed to see if the drug was safe and how it worked in healthy volunteers and people with moderate-to-severe asthma or COPD. The study was terminated, meaning it was…

This study tested whether an oral medication called dexpramipexole could help control severe asthma in people with a specific type called eosinophilic asthma. Over 1,000 participants aged 12 and up, whose asthma was not well-controlled despite standard medications, took either th…

This study tested whether a mucus-thinning drug called NAC could improve breathing in adults with moderate-to-severe asthma who had visible mucus plugs in their lungs on CT scans. Participants received either NAC or a placebo for two weeks, then switched. The trial was terminated…

This study tested an oral medication called dexpramipexole for people with a specific, hard-to-treat type of severe asthma. It aimed to see if taking the pill for a year could reduce the number of serious asthma attacks and improve lung function and quality of life. The trial inv…

This study aimed to test how a chewable asthma drug called fevipiprant is processed by the body in children aged 6 to 12. It was a short, 8-day trial to find the right dose for kids for future studies. However, the drug's development program was discontinued, so this study was te…

This study aimed to discover new causes of severe asthma attacks and better understand how common steroid inhalers work. Researchers analyzed mucus and saliva from 67 adults during a serious asthma episode. The goal was to find clues that could lead to new treatments by studying …