ASTHMA

This study will follow 130 adults with asthma that is not well controlled by their current medication. Researchers want to see if switching to a higher dose or a different combination of inhaled drugs can improve the function of the small airways in the lungs. Participants will t…

This study tests if a new drug called QL2302 works as well as the approved drug Tezspire for adults with severe asthma that is not controlled by current treatments. About 636 people will get injections every 4 weeks for 48 weeks, then be monitored for 12 more weeks. The main goal…

This study tests if a single steroid shot works as well as a 5-day course of steroid pills for adults with asthma who visit the emergency room. About 182 participants will be randomly assigned to receive either the shot or the pills. The goal is to see which treatment better prev…

This study tests a new drug called AK139 in 160 adults with moderate to severe asthma. The goal is to see if it improves lung function and reduces airway inflammation safely. Participants will receive either AK139 or a placebo, and researchers will monitor side effects and immune…

This study aims to create and test a digital screening and management system for adults with asthma and allergies. About 9,666 participants will use a digital platform for at least a year to track symptoms and behaviors, while some will also try non-drug strategies like anti-mite…

This study compares two proven asthma management strategies—PARTICS and MART—to see which works better at preventing severe asthma attacks. About 4,100 adults with moderate-to-severe asthma who are at risk for flare-ups will be randomly assigned to one of the two approaches and f…

This study tests a drug called depemokimab in people with Type 2 asthma who are at risk of serious attacks. The goal is to see if adding this drug to standard care can reduce asthma attacks, help patients achieve remission (no attacks and no need for steroid pills), and slow lung…

This study tests a new inhaler called QVM149, which combines three medicines, against a standard two-medicine inhaler in teenagers aged 12 to 17 with asthma. The goal is to see if the new inhaler improves lung function and asthma control more effectively. About 304 teens will tak…

This study tests whether a slow-release form of the hormone DHEA can help control asthma in adults aged 18 to 50. Researchers will measure asthma control using standard tests and check for side effects. The goal is to see if DHEA is a safe and effective add-on treatment for asthm…

This study tests a new inhaler (CHF 5993) that combines three medicines—an anti-inflammatory, a long-acting bronchodilator, and another bronchodilator—against a standard two-medicine inhaler in Chinese adults whose asthma is not well controlled despite current treatment. About 55…

This study offers continued treatment with benralizumab (Fasenra) to about 230 adults with asthma, eosinophilic granulomatosis with polyangiitis (EGPA), or hypereosinophilic syndrome (HES) who completed a previous benralizumab study and are still benefiting. The main goal is to m…

This study tests whether reducing radon gas in homes can improve asthma symptoms. Researchers will enroll 180 adults with uncontrolled asthma and measure how many days they have symptoms after radon mitigation. The goal is to see if a simple home fix can help manage the disease.

This study aims to see how accurate two simple questionnaires (GINA-P and ACT-P) are at measuring asthma control in adults. Researchers will compare the questionnaire results with standard lung function tests. The study will involve 144 adults with asthma who will answer question…

This study looks at whether having a lung doctor and an ear-nose-throat doctor see patients together is better than separate visits for people with both asthma and chronic sinusitis with nasal polyps. The main goal is to see if this joint approach reduces the need for oral steroi…

This study will test a program called CALM that helps Black adults with asthma learn to cope with stress. The goal is to see if the program is practical and helpful for this group. About 50 people will take part, and the study will measure how well they accept the program and if …

This study looks at whether CPAP, a machine that pushes air through a mask, can help people with large airway collapse (LAC) — a condition where the windpipe or main breathing tubes narrow or collapse. The study will involve 60 adults with LAC and aims to see if CPAP is acceptabl…

This study tests whether L-menthol, a minty compound, can reduce breathlessness and improve exercise ability in 20 adults with asthma. Participants will try both L-menthol and a placebo in a crossover design to compare effects. The goal is to see if this simple substance can make…

This study looks at whether adding a Chinese herbal formula called Liqin Zhike to standard asthma inhalers (ICS/LABA) can improve outcomes for people with cough variant asthma. About 236 adults newly diagnosed with this condition will take part. The main goal is to see if the com…

This study tests whether a program called Body Awareness Therapy can help adults with asthma breathe easier and feel better emotionally. Participants will do guided exercises focusing on posture, breathing, and body sensations over several weeks. The goal is to see if this approa…

This study tests a new nebulizer treatment made from tiny particles from stem cells (hUC-MSC-sEV-002) for people with both allergic rhinitis and asthma. The goal is to see if it is safe and can improve symptoms and quality of life. About 18 adults aged 18-60 will inhale the treat…

This study looks at whether a 12-week vegan diet can lower inflammation and improve immune markers in adults with mild to moderate asthma, compared to a regular diet. Researchers will measure blood markers of inflammation and allergy in 280 people aged 18-30. Participants will fo…

This study looks at whether giving people with heart or lung disease real-time air quality information helps them exercise outdoors with less pollution exposure. About 80 adults with conditions like asthma, COPD, or heart disease will use a smartphone app to guide their outdoor w…

This study uses artificial intelligence to understand how air pollution and climate change impact respiratory diseases like asthma and allergies. Researchers will gather health data from nearly 2,000 patients across Europe and analyze it with AI tools to find patterns. The goal i…

This study tests a simple idea: scheduling a telehealth appointment with an asthma specialist before patients leave the ER after an asthma attack. Many people never see a specialist afterward, missing out on treatments that could prevent future attacks. The study will compare thi…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will analyze a single blood sample to see how certain immune cells change during inflammation and infection. Participants won't receive direct …

This study looks at how breathing in wildfire smoke can lead to long-term lung problems like asthma, COPD, and lung cancer. Researchers will safely expose 24 healthy adults to different levels of smoke in a controlled setting. The goal is to learn who is most at risk and what bio…

This study looks at whether watching a medical TV drama can improve asthma knowledge in young adults (18-35) who don't have medical training. 48 participants from different countries will be randomly assigned to watch the drama or not, and their asthma knowledge will be tested. T…

This study will observe 42,000 children with asthma in China to understand how well their asthma is controlled and what types of airway inflammation they have. Researchers will use simple tests to group children by inflammation type. The goal is to help doctors choose better trea…