ASTHMA

This study tests whether a triple-combination inhaler (containing an anti-inflammatory, a long-acting bronchodilator, and another bronchodilator) works better than a standard double-combination inhaler for people whose asthma is not well controlled. About 644 adults with asthma w…

This study tests a new injectable drug called depemokimab in 30 children aged 6 to 11 with asthma that involves a specific type of inflammation. The drug is given alongside their usual asthma medicines to see how the body processes it, how well it works, and if it is safe. The go…

This study tests whether a single injection of dexamethasone works as well as a 5-day course of prednisone pills to prevent asthma patients from returning to the emergency room. About 182 adults with asthma will be randomly assigned to get either the shot or the pills. Researcher…

This study tests whether frequent sauna baths can reduce or eliminate bacteria that cause stubborn lung infections in people with conditions like COPD, asthma, or bronchiectasis. Researchers will track how long participants go without needing antibiotics and whether the bacteria …

This study tracks people with severe eosinophilic asthma who already take Fasenra (benralizumab) every 8 weeks. Participants use electronic monitors on their regular inhalers and a study-provided rescue inhaler (AirSupra) to see if asthma control stays steady throughout the dosin…

This study tests whether arranging a telehealth appointment with an asthma specialist before patients leave the emergency room increases follow-up care. Forty adults who come to the ER for an asthma attack will either get a scheduled telehealth visit or usual care. The goal is to…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests a family-empowered pulmonary rehabilitation program for school-age children (6-12 years) with asthma. The program includes education, skills training, and home-based guidance. Researchers will compare it to standard care in 92 children to see if it improves asthm…

This study tests whether a new inhaler with three medicines (CHF 5993) works better than a standard two-medicine inhaler (CHF 1535) for people whose asthma is not well controlled. About 554 adults in China will use one of the two inhalers for 24 weeks. The main goal is to see if …

This large study aims to create a digital screening and management system for adults with asthma and allergies. Nearly 10,000 participants will use a smartphone platform to track symptoms and receive guidance on three non-drug strategies: avoiding allergens (like dust mites), inc…

This study gives ongoing access to benralizumab (Fasenra) for people with asthma, eosinophilic granulomatosis with polyangiitis (EGPA), or hypereosinophilic syndrome (HES) who completed a prior benralizumab trial and still benefit from the drug. About 230 participants will receiv…

This study will test whether a 12-week vegan diet can lower inflammation in adults with mild to moderate asthma compared to a balanced omnivorous diet. Researchers will measure immune markers and asthma control in 280 participants aged 18-30. The trial is not yet recruiting.

This study tests a digital health assistant called 'Alex' to help children and teens aged 10 to 19 with asthma. Over six months, the app tracks lung function, symptoms, and medication use, and later gives personalized advice. The goal is to see if it improves asthma control and m…

This study tests two ways to use asthma inhalers to prevent serious attacks. One strategy (MART) uses a combination inhaler for daily control and quick relief. The other (PARTICS) adds a separate steroid inhaler whenever a rescue inhaler is used. About 4,100 adults with moderate-…

This early-phase trial is testing whether inhaling tiny particles from stem cells (called small extracellular vesicles) can safely help people with both allergic rhinitis and asthma. About 18 adults will receive either the active treatment or a placebo via nebulizer daily for two…

This study tests whether a slow-release form of the hormone DHEA can improve asthma control in adults aged 18 to 50. Standard asthma steroids can lower the body's own DHEA, so supplementing it might help. The trial will compare DHEA capsules to a placebo in 30 participants, measu…

This Phase 2 study tests a new drug called AK139 in 160 people with moderate to severe asthma. Participants receive either AK139 or a placebo by injection under the skin. The trial measures changes in lung function and asthma control over time, while also checking for side effect…

This study tests whether installing a radon mitigation system in homes can improve asthma symptoms. Researchers will compare a real system to a sham (inactive) system in 180 adults with uncontrolled asthma. The goal is to see if lowering radon levels leads to fewer days with asth…

This study looks at adults with asthma that is not well controlled by their current medium-dose inhaler. Researchers want to see if switching to a higher dose or a different type of inhaler can improve the function of the small airways in the lungs. About 130 participants will be…

This study tests a new once-daily inhaler called QVM149, which combines three medicines (indacaterol, glycopyrronium, and mometasone furoate) to control asthma. It will enroll 304 teenagers aged 12 to 17 and compare the new inhaler to a standard twice-daily treatment (salmeterol/…

This study tests whether a new drug called QL2302 works as well as the approved drug Tezspire for people with severe asthma that is not controlled by current treatments. About 636 adults aged 18-80 will receive injections every 4 weeks for 48 weeks, then be monitored for another …

This study compares a joint consultation with both a lung doctor (pulmonologist) and an ear-nose-throat (ENT) specialist against separate visits for people with asthma and chronic sinusitis with nasal polyps. The main goal is to see if the joint approach reduces the need for oral…

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study will check how well two simple questionnaires (GINA-P and ACT-P) measure asthma control in adults. About 144 people with asthma will answer questions about their symptoms and take a breathing test. The goal is to see if these questionnaires can reliably tell if someone…

This study will test a handheld ultrasonic spirometer against a conventional hospital spirometer in 100 adults with chronic respiratory diseases like COPD or asthma. Each participant will use both devices to see if the portable one gives accurate and reliable results. If successf…

This study tests whether an extra virgin olive oil and water mouthwash can remove more leftover asthma medication from the mouth than plain water. The medication residue can cause problems like thrush or sleep apnea. Twenty healthy adults and adults with asthma will rinse with di…

This study checks if a new propellant (HFA-152a) in asthma inhalers is as safe as the current one (HFA-134a). About 110 adults with asthma will use both types of inhalers and be monitored for side effects. The goal is to make sure the new propellant is safe for everyday use.

This pilot study tests a 12-month structured nursing program called RESPiraIA-Asma for adults with poorly controlled, non-severe asthma. The program combines education, inhaler training, home peak-flow monitoring, and personalized care plans, offered in-person, digitally, or mixe…

This study tests whether acupuncture can help people with mild-to-moderate chronic asthma breathe better and feel less anxious or depressed. 180 adults will be randomly assigned to real acupuncture, fake acupuncture, or usual care. The main goal is to see if real acupuncture impr…

This Phase 2 trial tests whether inhaling L-menthol before exercise can reduce breathlessness and improve exercise capacity in 20 adults with asthma. Participants will receive L-menthol or a strawberry-scented placebo in random order, then cycle to measure their breathing and dis…

This study looks at whether CPAP, a machine that pushes air through a mask at night, can help people with large airway collapse (LAC). LAC causes shortness of breath, cough, and wheeze, and is often mistaken for asthma. The study will test if a larger trial is possible by checkin…

This study tests a program called CALM that helps Black adults with asthma cope with stress. Researchers want to see if the program is practical and well-liked by participants. About 50 adults who have persistent, uncontrolled asthma and moderate-to-high stress will take part.

This early-stage study tests a new drug called BBT002 in healthy volunteers and people with chronic sinusitis, nasal polyps, and asthma. The main goal is to check the drug's safety and how the body processes it. Researchers will also look for signs that the drug helps control sym…

This study tests whether a program called Body Awareness Therapy can help adults with asthma improve their physical function, breathing, and emotional well-being. 67 adults with stable asthma will be randomly assigned to either the therapy group or standard care. The therapy incl…

This study tests whether adding a Chinese herbal formula called Liqin Zhike to standard asthma inhalers (ICS/LABA) can reduce the chance of cough returning in people with cough variant asthma. About 236 adults aged 18 to 70 who are newly diagnosed will take either the inhaler alo…

This study uses a quick, non-invasive breath test (FeNO) to measure airway inflammation in adults with asthma who are treated in primary care or community specialty clinics. The goal is to see how many patients have type 2 inflammation, which often goes undetected. Researchers ho…

This study will expose 24 healthy adults to different levels of wildfire smoke in a safe, controlled room to see how it affects their lungs and brain. Researchers want to understand why some people may be more vulnerable to long-term lung diseases like asthma, COPD, and lung canc…

This study tests whether giving people with heart or lung conditions real-time air pollution data helps them exercise outdoors more safely. 80 participants will use a smartphone platform that tracks their walking and local air quality. The goal is to see if this approach reduces …

This study will look at how well asthma is controlled in 42,000 children in China and what types of airway inflammation they have. Researchers will use tests to measure asthma control and inflammation patterns. The goal is to find ways to improve treatment, educate families, and …

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This study will analyze data from 500 adults to see if depression and asthma are connected, and if one might cause the other. Researchers will use medical records and genetic information to identify factors like age, smoking, or weight that could influence the link. No new treatm…

This study will test whether a brief educational session led by a nurse can help children aged 6-17 with asthma better manage their condition and use their inhaler correctly. The session covers understanding treatment, distinguishing between maintenance and rescue medications, an…

This study uses artificial intelligence to understand how air pollution and climate change impact respiratory diseases like allergic rhinitis and asthma. Researchers will gather health data from about 1,900 patients across Europe and analyze it with AI tools to find better ways t…

This study tests whether watching a medical TV drama can improve asthma knowledge in people aged 18–35 without medical backgrounds. About 48 participants from different countries will be randomly assigned to watch the drama or not. Researchers will measure changes in asthma-relat…