ASTHMA

This study tested a new daily inhaler called AZD8630 for adults whose asthma is not well-controlled despite using standard inhalers. Over 500 participants used the inhaler or a placebo for 12 weeks to see if it could reduce the risk of asthma attacks and improve lung function. Th…

This study followed 92 adults with severe asthma who were prescribed tezepelumab to see how well it controls asthma and reduces cough in real-world settings. Researchers measured asthma control and cough-related quality of life over 52 weeks to understand the drug's effectiveness…

This study tested if adding a second medicine (formoterol) to a common asthma steroid (budesonide) in one inhaler works better than the steroid alone for people whose asthma isn't well controlled. About 374 adults and teens used either the two-drug or one-drug inhaler twice daily…

This study looked at how well a three-in-one inhaler works for adults with asthma that wasn't fully controlled on their previous medications. It followed 281 patients in Bulgaria for 6 months after they switched to the new inhaler to see if their asthma symptoms and quality of li…

This study tested whether an asthma medication using a new, more environmentally friendly propellant (HFA-152a) is as safe as the same medication using the current standard propellant (HFA-134a). Over 800 adults with moderate to severe asthma participated in this 12-week trial. T…

This study aimed to monitor the long-term safety and effectiveness of the asthma medication FASENRA in real-world patients. It involved 653 people with severe asthma that was hard to control with other treatments. The main goal was to track any side effects and see how well the d…

This study tested whether connecting children to asthma care via telemedicine after an emergency room visit could help them feel better. Researchers enrolled 384 children with asthma who visited the ER and randomly assigned some to receive follow-up video appointments with a doct…

This study tested whether adding an experimental pill called QAW039 to standard asthma medications could help patients whose asthma is not well controlled. Over 12 weeks, researchers measured if the drug improved lung function, reduced daytime symptoms, and decreased the need for…

This small study tested whether giving free electronic cigarettes (e-cigs) to adult smokers with asthma would help them smoke fewer regular cigarettes. Seventeen participants were either given e-cigs or just monitored for 16 weeks. Researchers wanted to see if switching to e-cigs…

This study tested a program to help children avoid repeat asthma attacks after an emergency room visit. Kids who were treated in the ER for an asthma attack were given their daily controller medicine right at discharge. The program then arranged for school staff to supervise the …

This study tested if a new combination inhaler (CHF 1535) works better than a standard steroid inhaler (CHF 718) for adults with moderate-to-severe asthma. Over 1,300 participants used one of the two inhalers for 12 weeks. Researchers measured lung function, asthma symptoms, and …

This study tested a new combination inhaler for asthma against a standard inhaler and an existing treatment. It involved 645 adults and teenagers whose asthma symptoms were not well controlled despite using daily medication. The goal was to see if the new inhaler improved lung fu…

This study tested whether a simple, home-based exercise program could help adults with asthma. Thirty participants followed an 8-week program using basic equipment to see if it improved their breathing, walking ability, and overall asthma control. The goal was to offer a cost-eff…

This study tested if adjusting the dose of a common reflux medicine (lansoprazole) based on a child's genetic makeup could improve their asthma control. It involved 41 children aged 6-17 who had both asthma and mild reflux symptoms. Over six months, researchers compared asthma sy…

This early-stage study tested a new oral medication called TR4 in people with mild-to-moderate asthma. The main goal was to check if the drug was safe and how it affected the airways. Twelve participants received either the drug or a placebo in gradually increasing doses over sev…

This study tested a new inhaled drug called ARO-RAGE to see if it is safe and how it behaves in the body. It involved 127 healthy volunteers and people with asthma. The main goal was to check for side effects and measure how the drug moves through the body, with some tests on lun…

This study tested whether the drug dupilumab reduces lung inflammation and mucus buildup in adults with moderate-to-severe asthma. 109 participants received either dupilumab or a placebo for 24 weeks. Researchers used detailed lung scans and breathing tests to measure changes in …

This study observed 147 adults with moderate to severe asthma whose doctor had already decided to prescribe a specific triple-therapy inhaler (Trimbow) as part of their regular care. The goal was to see if using this single inhaler, which combines three medications, helped patien…

This study tested a new inhaled medication called AZD4604 for adults whose moderate-to-severe asthma was not well controlled by their usual high-dose inhalers. Over 300 participants used the drug or a placebo twice daily for 12 weeks. The main goal was to see if the new treatment…

This study tested whether people with asthma, including pregnant women, would regularly use a smartphone app connected to a home breathing monitor (peak flow meter) and share the data with their care team. The goal was to see if this home-monitoring approach was practical and acc…

This study tested if a new combination inhaler (PT027) works as well or better than a standard rescue inhaler (PT007) for adults with asthma. Researchers compared how quickly and effectively each inhaler opened airways after a breathing test that triggered asthma symptoms. The go…

This study looked back at the medical records of 140 people to see how well a specific allergy shot treatment worked for dust mite allergies. The treatment, given for at least one year, aimed to reduce allergy and asthma symptoms and the need for medication. Researchers checked s…

This study tested whether a daily oral medication called atuliflapon could help control asthma and prevent worsening episodes in adults whose asthma was not well-managed with standard inhaler treatments. About 670 participants took either the study drug or a placebo pill for 12 w…

This study directly compared two existing biologic drugs, dupilumab and omalizumab, to see which works better for adults with severe chronic sinusitis with nasal polyps and asthma. It involved 360 participants who had not gotten enough relief from standard treatments like nasal s…

This small pilot study tested whether sending weekly text or app reminders helped adults with severe asthma stick to a home monitoring routine. Thirty patients used a special device and smartphone app to measure their breathing weekly for three months. The study found that patien…

This early-stage study tested the safety of a new injection called XKH001, which is being developed for asthma. Researchers gave 24 healthy volunteers either the drug or a placebo injection to see how their bodies handled it. The main goal was to check for side effects and see ho…

This study tested whether a technology-based education program could help teenagers with asthma better manage their condition. Researchers compared programs led by trained teen peers to those led by adults, measuring effects on quality of life, asthma control, and confidence. The…

This study tested whether a new oral medicine called AZD4604 could reduce inflammation in the airways of adults with moderate-to-severe asthma. For 4 weeks, 36 participants took either the drug or a placebo pill, and researchers measured changes in cells and genes from lung sampl…

This study tested whether a drug called tezepelumab could improve lung structure and function in adults with moderate-to-severe asthma that remains uncontrolled despite standard treatments. Researchers used advanced MRI and CT scans to see if the drug reduced airway blockages and…

This study tested whether providing full hospital-level medical care in patients' own homes is a safe and effective alternative to traditional hospital stays for rural adults. It involved 160 adults with serious but manageable conditions like severe infections, heart failure, COP…

This early-stage study tested the safety of a new asthma drug called IBI3002 in healthy volunteers and people with mild to moderate asthma. Researchers gave single doses to 52 participants to check for side effects and see how the drug moves through the body. The main goal was to…

This study tested whether adding an investigational pill called QAW039 to standard asthma treatments could improve lung function and symptoms in people whose asthma was not well-controlled. Over 700 adults and teens took either the new pill or a placebo (dummy pill) for 12 weeks …

This study looked at how well and how safely the injectable medication tezepelumab works for people with severe asthma in real-world settings. It included 287 adults and adolescents whose asthma was not well controlled despite using standard high-dose inhalers and other controlle…

This study tested whether adding a new injectable medication called amlitelimab could help adults with moderate-to-severe asthma. Researchers compared different doses of the drug against a placebo in 446 participants over about a year. The main goal was to see if the treatment co…

This small, early-stage study tested whether a daily antioxidant pill called MitoQ could improve lung function in adults with both obesity and poorly controlled asthma. Over 14 weeks, 40 participants took either MitoQ or a placebo pill. The main goal was to see if MitoQ reduced a…

This study tested whether adding special breathing muscle training to a regular swimming program could help children with mild asthma breathe better and control their symptoms. Thirty children aged 8-11 did a 4-week swimming program, with half also doing daily breathing exercises…

This study compared two similar asthma medications (racemic albuterol and levalbuterol) in children ages 6-17 who came to the emergency room with moderate to severe asthma attacks. Researchers wanted to see which medication better improved children's breathing and reduced their n…

This study tested a smartphone-based program designed to help teenagers with moderate-to-severe asthma remember to take their daily inhaler medication. 72 teens aged 12-18 were assigned to either use this new program or continue their usual care. The program used text reminders, …

This early-stage study tested the safety and how the body processes a new inhaled drug called AZD8630 in adults with moderate-to-severe asthma. Twenty-four participants who were already using standard asthma inhalers took either the new drug or a placebo once daily for two weeks.…

This study tested if a new combination inhaler (CHF 1535) was better than a standard steroid inhaler at improving lung function in adults whose asthma was not well-controlled on their current medication. Over 500 participants used one of the two inhalers for 12 weeks while resear…

This study tested whether a training program for lung doctors and nurses could improve how asthma is managed in real-world clinics. About 1,500 asthma patients across China were followed for a year to see if their doctors, after receiving updated guideline training, prescribed be…

This study followed 513 people with severe, hard-to-control asthma for one year after they started taking tezepelumab, a prescription medication. The goal was to see how well the drug worked in everyday life, outside of a controlled clinical trial, by tracking asthma symptoms, br…

This study tested whether adding lunsekimig injections to standard asthma medications could better control moderate-to-severe asthma in adults. Researchers compared different doses against placebo injections in 685 participants worldwide to see if it reduced asthma attacks and im…

This study tested whether a new propellant (HFA-152a) in asthma rescue inhalers is as safe as the current standard propellant (HFA-134a). 477 adults with stable asthma used inhalers containing one of the two propellants for an extended period. Researchers monitored participants f…

This study aimed to understand how the asthma medication mepolizumab affects inflammation in the nose, lungs, and body of people with severe, hard-to-treat asthma. Researchers followed 15 adult patients for one year after they started the drug, measuring various markers in their …

This study tested whether a new propellant (HFO) in asthma inhalers causes breathing problems compared to the current propellant (HFA). Researchers enrolled 52 adults with well-controlled asthma who tried both propellants in a single dose. They measured lung function immediately …

This study tested whether having school nurses give children their daily preventive asthma medicine during the school day could help control their asthma better. It involved 29 children with persistent asthma from urban schools. The goal was to see if this school-based support co…

This study tested whether taking an unrefined salmon oil supplement, called CARDIO®, alongside standard asthma medication could help reduce inflammation and prevent asthma attacks. For 20 weeks, 70 adults with moderate asthma were randomly assigned to take either the salmon oil s…

This early-stage study tested the safety and how the body processes a new asthma medication called SAR443765. The trial involved 36 participants, including healthy adults and people with mild-to-moderate asthma, who received either the drug or a placebo. Researchers monitored sid…

This study followed 641 adults and adolescents with severe asthma for one year to check the long-term safety of an injected medication called depemokimab. Participants had already taken the drug in earlier trials. The main goal was to monitor for side effects and see if the drug …

This study tested a new support program for clinics to improve care for adults with multiple long-term conditions like HIV, diabetes, and high blood pressure. Over 1,800 participants in South Africa either received standard care or the new ENHANCE program, which included special …

This study tested whether a drug called tezepelumab, given as a shot, could help adults with severe asthma safely reduce or stop their daily oral steroid pills. It involved 305 participants who were already taking high doses of inhaled medicine plus daily steroid pills. The main …

This study tested whether taking a daily vitamin D pill could reduce serious lung problems in children and teens with sickle cell disease. Researchers compared daily vitamin D to a larger monthly dose over two years to see which was better at preventing infections, asthma attacks…

This study followed 620 adults whose asthma was not well-controlled on their current treatments. It tested whether switching to a specific combination inhaler (BDP/FF) delivered by a device called the NEXThaler could improve their asthma control over six months. Researchers measu…

This large, completed Phase 3 study tested if switching to a new, long-acting injection called GSK3511294 (depemokimab) was as good as staying on current treatments (mepolizumab or benralizumab) for controlling severe asthma flare-ups. It involved over 1,700 teens and adults with…

This study tested whether a smartphone app called Hyfe Cough Tracker could help monitor and manage coughs in people with various respiratory diseases. Over 600 participants with conditions like COPD, asthma, or COVID-19 used the app to record their coughs for up to 30 days. Resea…

This study aimed to see if two simpler tests—measuring a gas in a person's breath (FeNO) and counting a type of white blood cell (eosinophils)—could accurately diagnose asthma. It involved 123 people aged 12 and older whose doctors suspected they had asthma but whose initial brea…

This study tested whether giving a daily oral bacterial extract (Broncho-Vaxom®) to infants at high risk for asthma could prevent wheezing illnesses. Over 800 infants aged 6-18 months took the extract or a placebo for 10 days each month for two years, followed by three years of o…

This small pilot study tested whether a 12-week, doctor-prescribed exercise program delivered through a smartphone app is practical and acceptable for adults who have both obesity and poorly controlled asthma. Twenty participants used the app to follow a personalized exercise pla…

This study tested whether two different types of stretching exercises could help adults with asthma breathe more easily. Researchers compared chest-focused stretches with side-bending stretches over four weeks to see which improved chest expansion, reduced shortness of breath, an…

This study tested whether inhaling thyme oil could help people with asthma breathe better and control their symptoms. Researchers worked with 156 hospitalized adults in Turkey, having some use thyme oil inhalers, some use empty inhalers, and some receive no special treatment for …

This study tested whether adding acupuncture to standard asthma medication helps people feel better and use less medicine. Researchers compared real acupuncture to fake acupuncture in 200 adults with mild-to-moderate asthma over 6 weeks. They measured changes in asthma symptoms, …

This study tested a new experimental inhaler called PT007 to see how well it opens the airways in adults with asthma. It compared a single dose of PT007 to a dummy inhaler (placebo) and to a standard rescue inhaler (Ventolin) over a short period. The main goal was to measure the …

This study followed 112 adults with severe, hard-to-control asthma who were starting treatment with the drug dupilumab (brand name Dupixent®). The main goal was to see if their quality of life improved over one year of treatment in a real-world setting, outside of a tightly contr…

This study tested whether two non-drug techniques could help young people with asthma breathe easier and feel better. For 8 weeks, one group practiced Papworth breathing, a slow, calming method, while another group combined it with Bridge Pose yoga to open the chest. Researchers …

This small study tested whether a 5-week program of breathing and posture exercises, delivered online, could help young adults with asthma. Twelve female university students with stable asthma followed the program. Researchers measured if it improved their asthma control, breathi…

This study tested whether mepolizumab, an existing medication, could reduce the number of coughs in adults suffering from a long-term, hard-to-treat cough linked to specific airway inflammation. It involved 46 adults with chronic cough and evidence of eosinophilic airway disease,…

This study tested whether the Buteyko breathing technique could help people with asthma feel less tired, exercise more easily, and better control their asthma symptoms. It involved 90 adults recently diagnosed with asthma, who were split into two groups—one practicing the breathi…

This small, early-stage study tested whether inhaling a substance called Ectoin could help reduce airway sensitivity and inflammation in people with mild asthma. Researchers gave 18 adults increasing doses of the solution to find a safe and potentially effective amount. The main …

This study aimed to understand the safety of using the medication dupilumab during pregnancy. Researchers followed 581 pregnant women in North America, comparing those who took the drug for eczema or asthma to those who did not. The main goal was to check for any effects on the b…

This study aimed to understand if people with asthma have overactive nerves that control heart rate and blood pressure, similar to other lung diseases. Researchers tested a special nasal oxygen therapy (Nasal High-Flow Therapy) on 30 adults with asthma to see if it calmed this ne…

This study aimed to understand how the asthma medication dupilumab works at a cellular level in adults who have both asthma and obesity. Researchers collected nasal cell samples from 28 participants to analyze how the drug changes gene and protein activity. The goal was to learn …

This was an early-stage study to check the safety of a new injection called 9MW1911 in healthy people. The main goal was to see how well the body tolerated the drug and to find the highest safe dose. Researchers also measured how long the drug stayed in the body and if it trigger…

This study looked at whether newer biologic drugs for severe asthma help people be more productive at work. Researchers followed 174 employed adults with severe asthma for 6 months after starting a biologic treatment. The main goal was to see if their ability to work effectively …

This study aimed to understand how adults with severe, hard-to-control asthma are treated and how they fare in everyday life. Researchers followed over 1,500 patients across the US for at least three years, collecting data through regular online surveys and medical records. The g…

This study looked at whether improving a caregiver's depression could lead to better asthma control for their child. Researchers followed 205 caregiver-child pairs for one year, measuring depression and asthma symptoms regularly. The goal was to understand the connection between …

This study looked at whether adding special breathing muscle training to standard asthma rehab programs provides extra benefits. Researchers compared two groups of 84 adults with severe asthma to see if the training improved fitness, breathing, strength, and quality of life. A ke…

This study aimed to understand why some patients with severe asthma do not respond well to the drug mepolizumab. Researchers measured the drug levels in the blood of 50 patients who were already being treated, comparing those who improved with those who did not. The goal was to s…

This study aimed to understand if a person's blood type makes them more likely to have severe asthma attacks triggered by viruses like the common cold. Researchers compared 126 people with asthma, some who had been hospitalized for attacks and others who had not. They collected s…

This study observed and described cases of children hospitalized for serious breathing problems like bronchiolitis, pneumonia, or asthma. It involved 1,827 children under 2 years old across 12 hospitals in France. The main goal was to track these hospitalizations and understand t…

This study tested whether a computer algorithm could predict when patients receiving hospital-level care at home might get sicker. Researchers used past patient data to train the algorithm and then checked how well it worked on a new group of over 500 patients. The goal was to se…

This study looked back at the health records of nearly 20,000 adults with asthma to understand the long-term effects of steroid medications. Researchers compared patients who took higher doses of steroids over time with those who took lower doses. They wanted to see if higher ste…

This study observed how families use emergency asthma inhalers when children have symptoms at home. Researchers used smart inhalers to track medication use in 120 children with asthma. The goal was to gather real-world data to help create clearer, more consistent treatment guidel…

This study looked back at the medical records of 420 patients in Spain with severe, hard-to-control asthma who were treated with the biologic drug tezepelumab. The goal was to understand the real-world characteristics of these patients and see how the treatment affected their ast…

This study aimed to understand how a potential new asthma drug is processed by the body. Researchers compared the drug levels in the blood of 25 teenagers and 25 adults with stable asthma after they inhaled a single dose. The main goal was to see if the drug behaves similarly in …

This study aimed to understand how specific variations in a gene called COX-2 might influence the development of certain immune cells linked to allergic inflammation and asthma. Researchers enrolled 117 adults from a registry to compare blood and urine samples from people with di…

This study aimed to understand why some people have severe asthma that doesn't respond well to standard steroid treatments. Researchers followed 171 adults—some with severe asthma, some with milder asthma, and some healthy volunteers—over several years. By comparing medical tests…

This study aimed to collect samples from the lungs and blood of people with asthma and healthy volunteers. Researchers used a procedure called bronchoscopy to gently collect cells and fluid from the airways. The goal was to better understand the inflammation and processes that ca…

This study aimed to understand why children growing up on farms might get fewer or less severe colds and breathing problems. Researchers observed 290 children, ages 4-12, from farm communities and suburban areas, some with and some without asthma. They tracked the kids' cold symp…

This study aimed to understand if inflammation in the small, deep airways of the lungs could be better treated with inhaled steroids made of very small particles. Researchers compared a standard large-particle steroid to a new small-particle version in 57 adults with mild-to-mode…

This study looked back at past patient records to see if a computer program could learn to predict which patients are most likely to be readmitted to the hospital within 30 days after being sent home. Researchers used data from 372 patients who had been treated at home through a …

This study aimed to build a collection of health information and biological samples to find genes and other factors linked to asthma. It enrolled 83 adults of African, African American, or African Caribbean descent, both with and without asthma. Researchers collected questionnair…

This study aimed to understand why people with asthma often get sicker from common cold viruses like RSV. Researchers collected lung cells from 113 adults, both with and without mild asthma, to test in the lab. They wanted to see if a specific body chemical (TGF-beta) found more …

This study is following up with about 89,000 farmers and their spouses to better understand the long-term health effects of farming exposures like pesticides. Researchers are checking the accuracy of health problems participants have reported, such as asthma and Parkinson's disea…

This study looked at whether people with a grass pollen allergy (like hay fever) are more likely to develop asthma if they work with flour, such as bakers and pastry chefs. Researchers analyzed medical records from over 400 adults with asthma who visited a specialized clinic over…

This study tested if sending doctors a paper letter, in addition to an email, is more effective than an email alone at changing their prescribing habits. The goal was to see which method leads to more prescriptions of asthma inhalers with a lower environmental impact. It involved…

This study looked back at medical records and CT scans from 233 people with severe asthma who were taking biologic drugs. Researchers used computer analysis of the scans to see if body composition, like muscle size and quality, could predict who would have fewer asthma attacks or…

This study aimed to see if a simple, 6-minute stepping test could be a good way to measure exercise capacity in adults with asthma. Researchers compared the stepping test results to those from a more complex, lab-based exercise test in 41 participants. The goal was to find a quic…

This study aimed to discover new biological markers in the blood that could help doctors better diagnose and monitor two common lung diseases: asthma and COPD. Researchers analyzed blood samples from 205 people, including healthy volunteers and patients with these conditions. The…

This study aimed to improve inhaled medicine for asthma and COPD by understanding how patients breathe. Researchers measured the breathing patterns of 163 patients to feed into computer simulations. The goal is to see how different breathing affects where medicine lands in the lu…

This early-stage study aimed to understand how the body absorbs a common asthma relief drug (salbutamol) when it's delivered from an inhaler using a new, potentially more environmentally friendly propellant gas. Researchers compared this new propellant to the one currently used i…

This study tested a single dose of a new inhaled asthma medicine called AZD8630 in 10 teenagers with asthma. The main goal was to see how the drug moves through the body and to check for any side effects. Researchers also tested the inhaler device used to deliver the medicine.

This study followed 378 children with asthma for about a year to check the long-term safety and side effects of a medication called dupilumab. The children had all taken this medication in a previous study. Researchers also measured how well the drug continued to control asthma s…