ASTHMA

This study tests whether a three-in-one inhaler (budesonide, glycopyrronium, and formoterol) works better than two standard two-drug inhalers for people with asthma that is not well controlled. Adults and adolescents aged 12 to 80 with moderate-to-severe asthma will use the tripl…

This study tested a new inhaler that combines three medicines (beclometasone, formoterol, and glycopyrronium) against a standard two-medicine inhaler in over 1,100 adults with asthma that was not well controlled. The goal was to see if the triple combination improves lung functio…

This study tested a new inhaler that combines three medicines (beclometasone, formoterol, and glycopyrronium) in people whose asthma was not well controlled with standard two-medication inhalers. Over 1,400 adults took part for 52 weeks. The triple inhaler improved lung function …

This study tested a program where children with asthma receive their daily preventive medication at school, along with education and check-ups. The goal was to reduce asthma symptoms, emergency visits, and missed school days. The study included 29 children enrolled in a school-ba…

This study looked at whether adding special breathing muscle training to a swimming program could improve asthma control in children with mild asthma. Thirty children aged 8-11 took part in a 4-week swimming program, with half also doing breathing exercises twice daily. Researche…

This study tested whether a smartphone chatbot called Vik-Asthme can teach adults with asthma how to manage their condition as well as the usual in-person training. 73 adults with asthma were split into two groups: one received standard education, the other used the chatbot. Rese…

This study looked at over 4,000 people with asthma to see if Airsupra works better than albuterol at preventing severe asthma attacks in everyday life. Researchers reviewed medical records to compare how often attacks happened and how long it took for the first attack to occur. T…

This study tested whether taking high-dose fish oil (n-3 PUFA) for 6 months can improve asthma control in adults with a specific type of asthma called N-ERD, which is triggered by aspirin or NSAIDs. The 18 participants had poorly controlled asthma despite standard treatment. The …

This study followed 105 teenagers with severe uncontrolled asthma who were starting treatment with dupilumab (Dupixent). Researchers tracked their asthma control, flare-ups, and safety over one year. The goal was to see if this medication helps teens manage their condition better…

This early-stage trial tested a drug called itolizumab (EQ001) in 18 adults with moderate-to-severe asthma that is not well controlled by standard treatments. The main goal was to see if the drug is safe and how the body processes it. Researchers also looked for early signs that …

This phase II trial tested a drug called huMAb OX40L in 29 adults with mild allergic asthma. The drug is an antibody designed to block a protein that triggers allergic reactions in the airways. Researchers measured whether it could prevent breathing problems caused by allergens, …

This early-stage study tested a single shot of depemokimab, a biologic drug for asthma, in 20 healthy Chinese adults. Researchers measured how the drug moves through the body and checked for side effects. The goal was to gather safety and dosing information for future studies in …

This study tested whether switching to a new drug called depemokimab (GSK3511294) works as well as staying on current treatments (mepolizumab or benralizumab) for people with severe asthma linked to high eosinophils. Over 1,700 adults and teens took part for 52 weeks, continuing …

This study looked at 28 adults with both severe asthma and chronic sinusitis with nasal polyps who were treated with dupilumab for 24 months. The goal was to see if the drug could help control both conditions at the same time, called 'dual remission.' After 24 months, 88% of pati…

This study tested whether using Foster (a combination inhaler) for both daily maintenance and as-needed relief works better than using Foster daily plus a separate salbutamol rescue inhaler. Over 1,700 adults with not fully controlled asthma took part for 48 weeks. The main goal …

This study tested whether adding a bronchodilator called glycopyrrolate bromide to a standard steroid inhaler (Qvar) helps people with uncontrolled asthma breathe better. 98 adults with asthma took either the combination or a placebo for 6 weeks, then switched. The main goal was …

This study tested a new, environmentally friendly propellant (HFA-152a) in a common asthma inhaler (CHF5993) to see if it is as safe as the current propellant. Over 800 adults with moderate to severe asthma used the inhaler twice daily for 12 weeks. The main goal was to check for…

This study tested whether adding a drug called glycopyrrolate to a standard asthma inhaler (Foster) helps people whose asthma is not well controlled. 211 adults with uncontrolled asthma took part. The main goal was to see if the combination improved lung function over 12 hours. T…

This Phase 2 trial tested amlitelimab, an injectable drug, in 437 adults with moderate-to-severe asthma. Participants received either amlitelimab or a placebo alongside their usual asthma medications. The study measured how well the drug reduced severe asthma attacks and improved…

This completed Phase 2 trial tested several different drugs in 950 people with severe asthma. The goal was to see which treatments improve lung function and control symptoms. Participants tried each treatment for 16 weeks, with breaks in between, to find the best match for their …

This study looked at 43 adults in Taiwan with severe eosinophilic asthma who were already prescribed benralizumab. Researchers tracked changes in asthma control using a standard questionnaire over time. The goal was to see how well the drug works in everyday medical practice, not…

This study looked at whether the drug mepolizumab can improve symptoms in people with a specific combination of asthma, nasal polyps, and sensitivity to aspirin or similar painkillers. 95 adults received either mepolizumab or a placebo injection every month for 16 weeks. Research…

This pilot study tested a digital health platform that combines a smartphone app and connected inhaler sensors to help people with asthma track their medication use and technique. 94 adults with uncontrolled moderate-to-severe asthma in the UK used the platform for 6 months. The …

This Phase 2b study tested lunsekimig, an injectable drug, in 685 adults with moderate-to-severe asthma. Participants received either lunsekimig or a placebo alongside their usual asthma medications. The goal was to see if lunsekimig could reduce asthma attacks and improve breath…

This study tested whether a combination inhaler (CHF 1535, containing both a steroid and a long-acting bronchodilator) works better than a steroid-only inhaler in adults whose asthma is not well controlled despite high-dose steroids or medium-dose steroids plus another bronchodil…

This study tested a digital system that includes a smart inhaler, a phone app, and a dashboard for doctors to help people with asthma better manage their condition. Over 12 weeks, 333 participants aged 13 and older used either the smart system or their usual rescue inhaler. The g…

This study looked at how well the drug tezepelumab works for people with severe asthma when used in real-world settings, not just in controlled trials. Over 500 participants aged 12 and older were followed after starting tezepelumab. The main goal was to see if their asthma sympt…

This study tested an experimental inhaled drug called AZD8630 in 537 adults whose asthma is not well controlled despite using standard inhalers. Participants took the drug or a placebo once daily for 12 weeks. The goal was to see if the drug could reduce asthma flare-ups and impr…

This study tested a type of allergy immunotherapy (Clustoid® Max Forte) in 140 people aged 5 to 65 with dust mite allergies. The goal was to see if it reduces allergy and asthma symptoms and the need for medication over one year. Results were measured by symptom scores and medica…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study looked at 620 adults with asthma that was not well controlled on their current treatment. They were given a combination inhaler (beclometasone/formoterol) to use daily. After 6 months, researchers measured how many patients improved their asthma control using a standar…

This study tested a dietary supplement containing immune-supporting nutrients and postbiotics in 40 children aged 5–12 with asthma and/or allergic rhinitis. The goal was to see if the supplement could improve symptom control over 6 months. Researchers also looked at changes in im…

This pilot study tested whether adding asthma education through social media platforms like Facebook, Twitter, Instagram, and Snapchat could reduce hospital visits, emergency room trips, and clinic appointments for children with asthma. Two hundred children hospitalized for asthm…

This study tested a new inhaler containing two medicines (budesonide and formoterol) in 645 people aged 12 to 80 with asthma that was not well controlled. The trial compared the new inhaler to a standard budesonide-only inhaler and an existing combination inhaler over 24 weeks. T…

This completed Phase 3 trial tested whether a combination inhaler containing albuterol and budesonide (PT027) works better than albuterol alone (PT007) for treating sudden asthma attacks. 190 adults with asthma who only used rescue inhalers as needed took part. Researchers measur…

This study tested an inhaled solution of Ectoin, a natural substance, in 18 adults with mild asthma. The goal was to find a safe dose and see if it reduces airway sensitivity. Participants inhaled different doses over short periods, and results were compared to a placebo. The stu…

This study tested whether a combination inhaler containing both an anti-inflammatory steroid (budesonide) and a fast-acting bronchodilator (formoterol) works better than the steroid alone for people whose asthma is not well controlled. 374 adults and adolescents took part over 12…

This study tested a daily pill called atuliflapon in 670 adults with moderate to severe asthma that is not well controlled by current treatments. The goal was to see if the drug could reduce asthma flare-ups over 12 weeks compared to a placebo. The trial is now complete, and resu…

This study looked at the long-term safety of a drug called depemokimab in 641 adults and teenagers with severe asthma caused by a type of white blood cell called eosinophils. Participants had already completed earlier studies and received the drug for another 12 months. The main …

This study tested whether a mobile health app, paired with a Bluetooth-enabled peak flow meter, could help people with asthma track their breathing. 83 adults with asthma, including some who were pregnant, used the app to measure their lung function. The goal was to see if this a…

This study tested whether adding a daily pill called QAW039 to standard asthma treatments helps people with uncontrolled asthma breathe better. Over 700 adults and teens took either QAW039 or a placebo for 12 weeks. The main goal was to see if lung function (measured by how much …

This study tested whether a daily pill called QAW039 can help people with uncontrolled asthma breathe better. 675 adults and teens took either the drug or a placebo for 12 weeks, on top of their usual inhalers. The main goal was to see if lung function improved.

This study tested an 8-week home-based pulmonary rehabilitation program for adults with asthma. The program included stretching, strengthening, breathing exercises, and walking, using simple equipment found at home. Researchers measured changes in lung function, exercise capacity…

This study tested tezepelumab, a monoclonal antibody, in 27 adults with uncontrolled moderate-to-severe asthma. The goal was to see if it improves lung function and reduces airway inflammation and blockages. Participants received either tezepelumab or a placebo, and researchers u…

This study tested whether a technology-based education program, delivered by peer mentors or adult educators, helps teenagers aged 14-17 with asthma. 48 teens were split into two intervention groups and a control group. The program aimed to improve asthma control, quality of life…

This study tested a single injection of a new drug called SHR-1905 in 9 teenagers with asthma. The goal was to see how the drug moves through the body, if it is safe, and if it helps control asthma. Participants were aged 12 to 17, had asthma for at least 6 months, and were on st…

This early-stage study tested a new drug called TR4 in 12 adults with mild-to-moderate asthma. TR4 is a beta-2 blocker, which works differently than typical asthma treatments. The main goal was to see if it is safe and tolerable, and to measure its effects on lung function and ai…

This study tested a drug called tezepelumab in 305 adults with severe asthma who were already taking daily steroid pills. The goal was to see if tezepelumab could help them safely reduce or stop their oral steroids without losing asthma control. Participants received tezepelumab …

This study looked at how much of the asthma drug CHF 6001 gets into the blood of teenagers compared to adults after a single inhaled dose. Fifty people with asthma took part, including teens aged 12 to 17 and adults up to 75 years old. The goal was to see if the drug behaves simi…

This study followed 378 children with asthma who had already taken dupilumab in an earlier trial. Researchers wanted to see if the drug is safe and tolerable over a full year. They also measured how well it controls asthma symptoms. The goal was to make sure long-term use is safe…

This study tested a new way to help children with asthma take their medicine properly. Kids who came to the emergency room for an asthma attack were given their medications right there, and then school staff supervised their daily use. The goal was to see if this approach could r…

This study tested an experimental inhaled drug called AZD4604 in 339 adults with moderate-to-severe asthma that remains uncontrolled despite standard treatment. Participants took the drug or a placebo twice daily for 12 weeks. The main goal was to see if the drug could reduce ast…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a new drug called AZD4604 in 36 adults with moderate-to-severe asthma. The goal was to see if it reduces airway inflammation and affects certain genes over a 4-week treatment period. Participants took either the drug or a placebo, and researchers measured change…

This study tested a computer-based program that reminds doctors to follow asthma guidelines for children aged 2 to 12 with persistent or uncontrolled asthma. The program helped doctors take more corrective actions, like adjusting medication or checking triggers. The goal was to r…

This completed phase 4 trial directly compared two injectable drugs, dupilumab (Dupixent) and omalizumab (Xolair), in 360 adults with severe chronic rhinosinusitis with nasal polyps and asthma. The main goals were to see which drug better reduced polyp size and improved sense of …

This study tested a drug called tezepelumab in 287 adults and teens with severe asthma, including groups often left out of research. The goal was to see if the drug reduces asthma attacks and is safe over 52 weeks. Results showed fewer flare-ups compared to the year before starti…

This study tested the drug tezepelumab in 92 adults with severe asthma to see if it improves asthma control and reduces chronic cough. Participants took the drug as prescribed by their doctor, and researchers tracked their symptoms and quality of life for a year. The goal was to …

This study tested whether taking vitamin D every day could reduce lung complications in children and teens with sickle cell disease. Lung problems like infections, asthma attacks, and acute chest syndrome are major causes of illness and death in this condition. Researchers gave d…

This study looked at 205 pairs of caregivers with major depression and their children (ages 7-17) with asthma. Caregivers could choose to take standard antidepressant medication or not. Researchers tracked changes in the caregiver's depression and the child's asthma control over …

This study tested whether a salmon oil supplement called CARDIO® could help control asthma in adults. 70 participants took either the supplement or a placebo alongside their usual asthma medications. The goal was to see if the supplement reduced asthma attacks and improved breath…

This study tested a stepped-care program called TASC to help teenagers with moderate to severe asthma stick to their daily inhaler routine. 72 teens were randomly assigned to either the program or usual care. The program starts with simple reminders and steps up to more support i…

This study tested whether adjusting the dose of a common acid reflux medicine (lansoprazole) based on a child's genes could improve asthma control. 41 children aged 6-17 with uncontrolled asthma and mild reflux participated. Researchers measured changes in asthma symptoms and ref…

This study tested dupilumab (Dupixent) in 109 adults with uncontrolled moderate-to-severe asthma. Researchers used lung scans and breathing tests to see if the drug reduces airway inflammation and mucus plugging. Participants received either dupilumab or a placebo for 24 weeks. T…

This study tested a telemedicine program to help children with asthma get better follow-up care after an emergency room visit. The program included a video visit at school within a week of discharge, plus two more check-ins. Researchers measured how many symptom-free days childre…

This study tested whether a combination inhaler containing both an anti-inflammatory steroid (beclomethasone) and a fast-acting bronchodilator (formoterol) works better than a steroid-only inhaler for adults with asthma. Over 1,300 participants on medium or high-dose steroids too…

This study looked at the long-term safety and effectiveness of Fasenra (benralizumab) in 653 people with severe asthma that wasn't controlled by other treatments. Researchers tracked side effects and asthma control over time. The goal was to confirm that Fasenra works well and is…

This study tested whether a special MRI technique can measure airway thickness in asthma patients as well as CT scans do, but without radiation. Thirty adults with asthma underwent both scans. The goal is to find a safer way to monitor airway changes over time.

This study looked at a new, non-invasive test to identify asthma patients with high levels of an enzyme called GSNOR, which can cause airway swelling. The test involves inhaling a substance called GSNO and measuring changes in breath and lung function. Researchers hope this offic…

This study looked at two simple tests—a breath test (FeNO) and a blood test (eosinophil count)—to see if they can diagnose asthma more easily than current hospital-based breathing tests. Researchers studied 123 people aged 12 and older with suspected asthma. The goal was to find …

This study tested whether a monthly oral bacterial extract (Broncho-Vaxom) could prevent wheezing lower respiratory tract infections in infants aged 6-18 months who are at high risk for asthma. Over 800 participants received either the extract or a placebo for 10 days each month …

This study tested whether giving pregnant women daily vitamin D supplements (4000 IU) could prevent asthma or recurrent wheezing in their children during the first three years of life. The trial enrolled 876 pregnant women with a personal or family history of asthma or allergies.…

This study tested a program that teaches coping skills and asthma management to Latino children with asthma and their families. The goal was to see if reducing stress could improve asthma control and quality of life. 282 children aged 8-14 took part, comparing the combined progra…

This study looked at whether breathing exercises can improve quality of life for adults with asthma who also have dysfunctional breathing (a pattern of breathing that causes shortness of breath). About 190 adults with poorly controlled asthma took part. Half received usual care, …

This early-stage study tested the safety of a new drug called IBI3002 in 40 healthy volunteers and 20 people with asthma. Participants received either the drug or a placebo, and researchers monitored for side effects. The goal was only to check if the drug is safe enough to study…

This study tested a device that teaches people with COPD or asthma how to use their inhalers correctly. About 140 adults aged 18-85 who already use specific inhalers will be trained with either the device or standard brief instruction. The goal is to see if the device improves in…

This study tested a procedure called bronchial thermoplasty for people with severe asthma that is not controlled by standard treatments. The treatment uses heat to thin the airway muscles, aiming to reduce breathlessness during exercise. 14 participants were enrolled, and the mai…

This study tested whether wearing an abdominal binder (a supportive wrap around the belly) along with doing special breathing exercises could help people with asthma feel less breathless and improve their quality of life. Thirty-two adults with mild to moderate asthma took part o…

This study tested two methods of giving salbutamol (a common asthma rescue drug) to 16 adults with mild asthma. One method used a vibrating mesh nebulizer, the other a standard inhaler with a spacer. The goal was to see which one reversed airway narrowing faster and more complete…

This pilot study tested whether giving two asthma medications (ipratropium and dexamethasone) to children during ambulance transport can reduce hospital admissions. The study included 44 children aged 2 to 17 with severe wheezing. The goal was to see if this early treatment is fe…

This study looked at whether two drugs, mirabegron and montelukast, are safe and helpful for people with liver cirrhosis who also have overactive bladder and asthma. 78 participants took part over 3 months. Researchers tracked bladder symptoms, breathing issues, and side effects …

This study tested whether a mobile app that lets people with asthma report their symptoms between doctor visits can improve their quality of life. Over 400 adults with asthma used either the app or received usual care. Researchers measured changes in asthma-related quality of lif…

This early-stage study tested an inhaled medication called ARO-RAGE in 127 healthy volunteers and people with asthma. The goal was to check safety and how the drug affects lung function. Participants received one or two doses of the drug or a placebo. Results will help decide if …

This study tested a mobile app called AIM2ACT that helps teens aged 12-15 with poorly controlled asthma work with their caregivers to manage symptoms. The app includes daily check-ins, goal setting, and training videos. The goal was to see if using the app improves asthma control…

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids were randomly …

This study tested whether the color of an asthma inhaler (pink vs white) affects how people perceive their asthma symptoms. 78 adults with moderate to severe asthma used both colored inhalers and reported their symptoms daily. The goal was to see if the device color alone could c…

This pilot study tested whether a remote digital exercise program (Vitala app) is feasible and helpful for adults with obesity and poorly controlled asthma. Twenty participants received a tailored exercise prescription and were encouraged to complete 150 minutes of activity per w…

This study followed 281 adults with asthma for 6 months to see if a triple-combination inhaler (BDP/FF/G) improves symptom control in everyday life. Participants had asthma for at least 3 years and were not well controlled on their current treatment. The main goal was to measure …

This early-stage trial tested an experimental drug called SHR-4597, given as an inhaled powder, in 62 healthy volunteers and people with asthma. The main goal was to see if it is safe and tolerable. The study gave single doses to healthy people and multiple doses over several day…

This study looked at whether Papworth breathing (a slow, controlled breathing method) combined with Bridge Pose yoga could help people with asthma. 58 people aged 15-20 with mild to moderate asthma took part. One group did only Papworth breathing, while the other added Bridge Pos…

This study checked if a new propellant (HFA-152a) in salbutamol rescue inhalers is as safe as the current one (HFA-134a) for adults with asthma. 477 participants used the inhalers over time, and researchers tracked side effects. The goal was to ensure the new propellant is safe f…

This study tested whether acupuncture can improve asthma control in adults with mild-to-moderate persistent asthma. Two hundred participants were split into two groups: one received real acupuncture and the other received sham (fake) acupuncture, both over six weeks. The main goa…

This study tested a new ventilator mode called NAVA for people with chronic obstructive pulmonary disease (COPD) who need a breathing machine. NAVA uses the patient's own diaphragm signals to control the machine, aiming to improve comfort and reduce time on the ventilator. The st…

This study looked at 101 children aged 6 to 17 with moderate to severe asthma attacks in the emergency room. It compared two medications, racemic albuterol and levalbuterol, to see which one improved breathing better and reduced the need for hospital admission. The goal was to fi…

This study tested whether a new propellant (HFO) in asthma inhalers causes airway narrowing (bronchospasm) compared to the standard propellant (HFA). It involved 52 adults with well-controlled or partially controlled asthma. Researchers measured lung function right after use and …

This pilot study tested whether weekly reminder messages help adults with severe asthma stick to home-based lung function monitoring using a digital device. Thirty patients used the AioCare spirometry system for 12 weeks. Those who got reminders completed more monitoring sessions…

This study tested whether the Buteyko breathing technique, a method of controlled breathing, can reduce fatigue and improve exercise capacity and asthma control in people with asthma. 90 adults with a recent asthma diagnosis were split into two groups: one learned the Buteyko tec…

This study looked at whether breathing and posture exercises, done at home through video calls, could help young adults with asthma. Twelve people aged 18-26 with stable asthma took part. The exercises aimed to improve breathing, posture, and quality of life. Results showed poten…

This study tested two types of stretching exercises—thoracic cage stretching and intercostal stretching—in 56 adults with asthma. The goal was to see if these stretches could improve chest expansion, reduce shortness of breath, and increase oxygen levels. Participants did the str…

This Phase 1 trial tested the safety and tolerability of a new drug called 9MW1911 in 48 healthy adults. The drug is being developed for asthma, COPD, and atopic dermatitis. Participants received either the drug or a placebo by IV infusion, and researchers monitored side effects …

This study followed 112 adults with severe asthma who were starting treatment with dupilumab (Dupixent). Researchers measured changes in quality of life using a standard questionnaire at 12, 24, and 52 weeks. The goal was to see if the drug helps people feel better and breathe ea…

This completed Phase 1 trial tested whether MitoQ, a drug that targets cell energy centers, can improve airway reactivity in 47 obese adults with poorly controlled asthma. Participants took MitoQ or a placebo daily for 12 weeks. The study aimed to see if MitoQ could help control …

This early-stage trial tested a single dose of the experimental drug IBI3002 in 52 healthy volunteers and people with mild to moderate asthma. The main goal was to check safety and how the body processes the drug. Researchers monitored side effects and drug levels in the blood ov…

This early-stage study tested a single inhaled dose of a new drug called AZD8630 in 10 teenagers with asthma. The main goal was to see how the drug moves through the body and to check for any safety issues. Participants used a dry powder inhaler and were monitored for side effect…

This early-stage study tested an experimental inhaler called AZD8630 in 24 adults with asthma who already use medium-to-high dose steroid inhalers and long-acting bronchodilators. Participants took the drug once daily for 2 weeks to check its safety, how the body processes it, an…

This study tested whether mepolizumab, a drug already used for asthma, can reduce coughing in people with chronic cough and eosinophilic airway disease. 46 adults received either the drug or a placebo over 12 weeks. The main goal was to see if cough frequency decreased, measured …

This study tested whether inhaling thyme oil can help people with asthma control their symptoms and improve lung function. 156 adults admitted to a hospital in Turkey used either a thyme oil inhaler, an empty inhaler, or no inhaler for four days. Researchers measured asthma contr…

This early-stage trial tested the safety and tolerability of a new drug called SAR443765 in 36 people, including healthy volunteers and those with mild-to-moderate asthma. Participants received either the drug or a placebo, and researchers monitored for side effects and how the d…

This study tested a single dose of a new albuterol inhaler called PT007 in 118 adults with asthma. Researchers compared how well it opened airways and its safety against a placebo inhaler and the standard Ventolin inhaler. The goal is to see if PT007 works as a quick-relief treat…

This pilot study tracks changes in a specific inflammatory marker (IL-1β) in the nasal passages of adolescents during an asthma attack. Researchers collect nasal fluid samples daily for five days during an attack and compare them to baseline samples taken when the participant is …

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study examined whether a chemical called TGF-Beta, which is more common in the lungs of people with asthma, makes them more vulnerable to respiratory syncytial virus (RSV). Researchers collected lung cells from 113 healthy adults and mild asthmatics using a bronchoscopy. The…

This study looks at whether a friendly robot can help children with asthma learn how to manage their condition. About 120 kids and their parents will test the robot's lessons and activities. The goal is to see if the robot is easy to use and helpful in a clinic setting.

This study followed 171 adults with severe asthma, milder asthma, or no asthma over several years. Researchers collected health data, lung tests, and samples to understand how severe asthma progresses and differs from other forms. The goal is to find new ways to treat people whos…

This study looked at how small differences in the COX-2 gene affect the balance of immune cells that play a role in allergies and asthma. Researchers analyzed blood and urine samples from 117 adults who were part of a larger genetic registry. No treatments were given; the goal wa…

This study tested whether a CT scan of the lungs could predict which patients with severe eosinophilic asthma would respond well to the drug benralizumab. 59 adults received benralizumab for 48 weeks and had CT scans at the start, middle, and end of treatment. The goal was to see…

This study tested two different injection devices (a safety syringe and an autoinjector) to see how the body absorbs depemokimab, a potential asthma treatment. 140 healthy adults received a single dose. The goal was to compare the drug levels in the blood, not to treat asthma.

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This completed study looked at 83 adults of African, African American, or African Caribbean descent to find genetic and environmental factors linked to asthma. Participants provided blood, skin, and breathing test data. The goal was to build a resource for future research, not to…

This completed study tested different ways to use a nebulizer for asthma medication. 36 people with mild to moderate asthma received the drug salbutamol through various nebulization modes. The goal was to see which mode delivers more medication to the lungs and reduces waste. Res…

This study collected fluid and cells from the lungs of 574 people with asthma and healthy volunteers using a thin tube called a bronchoscope. The goal was to learn more about airway inflammation and what causes it. The findings may help identify new targets for future asthma trea…

This study looked at the medical records of one person from a sleep clinic to see if their breathing problems were due to a condition called dysanapsis (where airways are smaller than normal) rather than true asthma. The goal was to better understand why some people with sleep ap…

This completed registry followed 718 asthma patients who were starting treatment with DUPIXENT as part of their normal care. Researchers collected information on patient backgrounds, how the drug was used, its long-term effectiveness, and safety in everyday settings. The goal was…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested a new way to monitor breathing at home in 120 adults with severe asthma. The goal was to see if a special analysis of resting breath patterns could predict when an asthma attack might occur. The approach is observational and aims to improve early warning, not to…

This completed observational study included 123 adults with COPD or asthma. Researchers measured breathing muscle strength using a special device and then tried to predict those results from simpler tests like spirometry and body composition. The goal was to see if doctors could …

This study checked whether a Turkish version of the Brompton Breathing Pattern Assessment Tool (BPAT) works well for people with asthma. Researchers tested 101 Turkish-speaking adults with severe asthma to see if the tool gives consistent results and matches other breathing tests…

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This early-stage study tested a single injection of HBM9378 in 50 healthy Chinese adults to see if it is safe and how the body processes it. The goal was not to treat asthma but to gather safety and drug-level data. Participants were healthy, not asthma patients, so no direct ben…

This study looked at blood and airway samples from 23 adults during an acute asthma attack and again after recovery. The goal was to understand what happens in the body during an attack. This is a pilot study, meaning it is small and meant to generate ideas for future research, n…

This study looked at 39 children with asthma to see if those with depression have a different type of airway response. Researchers tested whether an anticholinergic inhaler (ipratropium) works better in depressed versus non-depressed children. The goal was to better understand th…

This study looked at whether a set of care guidelines (called a pathway) could help doctors and nurses in community hospitals use the best treatments for children hospitalized with asthma, pneumonia, or bronchiolitis. Over 11,000 children took part across many hospitals. The goal…

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This completed phase 1 study in 24 healthy adults compared a new inhaler propellant (HFA-152a) to a standard one (HFA-134a) to see if it affects how the lungs clear mucus. Participants inhaled each propellant for several days, and lung clearance was measured using a radioactive t…

This completed observational study followed 2,660 children aged 5 to 16 with and without asthma to understand how environment and biology affect asthma control. Researchers collected saliva, nasal, and urine samples to find predictors of asthma flare-ups and medication adherence.…

This study looked at whether teaching children with asthma about their condition helps them understand it better, control symptoms, and feel better day-to-day. 70 children aged 7-11 took part. Researchers measured asthma knowledge, control, and quality of life before and after th…

This early-stage study tested a single dose of the experimental antibody SM17 in 30 healthy Chinese adults to see if it is safe and how the body processes it. The study did not aim to treat any disease. Results will help plan future trials for conditions like eczema, asthma, and …

This study looked at gene activity in cells from the nose and lungs of 44 healthy and allergic adults. The goal was to understand how allergies change these cells and why the nose and lungs react differently. Researchers hope this knowledge will lead to better treatments for alle…

This study looked at why obese people with asthma often have more severe symptoms and don't respond well to standard treatments. Researchers used special MRI scans and genetic analysis to examine airway changes in 49 obese adults with asthma. The goal was to better understand the…

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study observed over 1,800 children hospitalized for serious breathing problems like bronchiolitis, pneumonia, or asthma. It aimed to track how many children were hospitalized for bronchiolitis after a new immunization became available. The study did not test any new treatmen…

This study looked at whether a person's blood group antigens are linked to asthma attacks. Researchers followed 126 people with asthma to see if certain blood types had more flare-ups requiring steroids. The goal was to understand, not treat, the disease.

This study tested an experimental drug called XKH001 in 24 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection. The goal was to check for side effects and measure drug levels in the blood, not to treat…

This study looked at whether the drug dupilumab, used for eczema or asthma, is safe during pregnancy. Researchers compared 581 pregnant women who took dupilumab with those who did not. They tracked birth defects, miscarriages, and infant health up to one year old to see if the dr…

This study tested a Turkish version of the Respiratory Distress Observation Scale (RDOS) in 100 adult palliative care patients who cannot describe their breathing trouble. The scale uses eight physical signs like heart rate and restlessness to rate distress. The goal was to see i…

This study looked at how different breathing exercises affect genes and symptoms in 84 adults with severe asthma. Participants did either standard respiratory rehab or the same program plus extra muscle-strengthening breathing exercises. Researchers measured changes in a specific…

This study tested whether a 6-minute stepper test is a valid and reliable way to measure exercise capacity in adults with asthma. 41 participants with well-controlled asthma performed the stepper test and a standard treadmill test. The goal was to see if the simpler stepper test …

This completed study looked at how nasal high-flow therapy (NHFT) affects breathing and the nervous system in 30 adults with asthma. Researchers measured nerve activity and heart rate to see if NHFT could reduce overactive stress signals. The goal was to gather knowledge, not to …

This study looked at how the drug dupilumab changes gene and protein activity in airway cells from adults with asthma and obesity. Researchers compared allergic and non-allergic participants to understand different treatment responses. The goal was to gather knowledge, not to tes…

This study looked at whether sending paper letters along with emails helps doctors change how they prescribe asthma inhalers. The goal was to increase use of inhalers that are better for the environment and improve patient care. 273 primary care practices in West Yorkshire took p…

This study looked at inflammation in the small airways of the lungs in people with asthma. Researchers tested whether a steroid with small particles could reach these deep areas better than a steroid with large particles. 57 adults with mild to moderate asthma took part. The goal…

This study looked at whether a family of proteins called GPCRs, found on the surface of cells, can be used as biomarkers to diagnose or track chronic lung diseases like asthma and COPD. Researchers analyzed blood samples from 205 people (healthy volunteers and patients) to see if…

This study looked at whether children who grow up on farms, with more exposure to microbes, have fewer severe colds and breathing problems. Researchers tracked 290 children aged 4 to 12, including farm kids and city kids with and without asthma. The goal was to understand how ear…

This study looked back at medical records of 420 people with severe asthma in Spain who were given tezepelumab after it was approved. The goal was to see how well the drug works in real life, not just in controlled trials. Researchers tracked things like asthma attacks, symptoms,…

This study tested a new propellant (HFA-152a) in salbutamol inhalers to see if it works like the current propellant (HFA-134a). Sixty healthy adults aged 18-55 received single doses of salbutamol via both inhalers. The goal was to measure how much drug gets into the blood and how…

This study tested whether a program that educates doctors on the latest asthma guidelines can improve how they treat patients. About 1500 people with asthma in China took part. The program included training sessions and reminders to help doctors follow best practices. The main go…

This study looked at 174 adults with severe asthma who were starting biotherapy. Researchers wanted to see if their ability to work (despite health issues) improved after 6 months of treatment. The goal was to understand which factors, like asthma control or other health problems…

This study examined 403 adults to see if grass pollen allergies are more common in workers exposed to flour, like bakers and pastry chefs, compared to other professions. Researchers analyzed past medical records to understand what factors influence asthma symptoms in these worker…

This study looked at how mepolizumab, a biologic drug, changes inflammation in people with severe eosinophilic asthma. Researchers measured immune and metabolic markers in the nose, lungs, and blood of 15 adults. The goal was to better understand the drug's full impact beyond jus…

This study observed 120 children with asthma, aged 3 to 11, using smart inhalers to track how and when they used emergency medication at home. Parents also answered questions via a mobile app about symptoms and treatment effectiveness. The goal was to gather real-world data to cr…

This study measured breathing patterns in 163 adults with asthma or COPD to help computers predict how much of an inhaled drug actually reaches the lungs. Researchers used these real-world breathing measurements to improve simulations of aerosol drug deposition. The goal is to ma…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with lung conditions like COPD, asthma, or COVID-19. Researchers compared the app's cough counts to patients' own reports and expert listening. The goal was to improve …

This study looked at CT scans from 233 severe asthma patients to see if body composition (like chest muscle size and quality) could predict how well they respond to biologic therapies. Researchers used advanced imaging analysis to find biomarkers linked to fewer asthma attacks. T…

This study looked at nearly 20,000 adults with asthma to see if long-term use of inhaled or oral steroids increases the risk of osteoporosis (weak bones) and other metabolic diseases like diabetes and high blood pressure. Researchers compared people who took higher total doses of…

This study gave free e-cigarettes to 17 adult smokers with asthma for 8 weeks to see if they would smoke fewer regular cigarettes and have better lung function. Researchers measured changes in smoking habits, dependence, and asthma symptoms. The goal was to gather early informati…

This study followed 80 teens with asthma to see how well they used their daily controller and rescue inhalers. Participants used an electronic device that reminded them to take their medication and shared their usage patterns with their doctor and family. The goal was to group te…

This study measured the amount of mepolizumab in the blood of 50 adults with severe asthma who were already taking the drug. Researchers compared drug levels between those who responded well to treatment and those who did not. The goal was to see if differences in how the body pr…

This completed study followed 18 adults with severe asthma in the United States for at least 3 years. Researchers collected data on treatments, symptoms, hospital visits, and quality of life from medical records and monthly patient surveys. The goal was to understand how severe a…

This completed study followed 147 adults with moderate to severe asthma who were prescribed Trimbow, a triple-therapy inhaler, as part of their routine care. Researchers collected data on patient characteristics, treatment patterns, asthma control, quality of life, and lung funct…