New asthma study aims to match treatments to patients

NCT ID NCT04129931

Completed Disease control Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 2 trial tested several different drugs in 950 people with severe asthma. The goal was to see which treatments improve lung function and control symptoms. Participants tried each treatment for 16 weeks, with breaks in between, to find the best match for their asthma type.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Multiple drugs: MCT (dietary supplement), Clazakizumab (anti-IL-6 antibody), Broncho-Vaxom (bacterial extract), Imatinib Mesylate (cancer drug)

What this could lead to

If successful, this could help doctors choose the right treatment for each person with severe asthma, improving control and reducing flare-ups.

What could go wrong

This is a Phase 2 trial, so results are still early. The treatments may not work for everyone, and some have side effects like infection risk or liver issues.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

asthma chronic asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

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Locations

Ann & Robert H. Lurie Children's Hospital

Chicago, Illinois, 60611, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Cleveland Clinic

Cleveland, Ohio, 44106, United States
Columbia University Medical Center

New York, New York, 10031, United States
Mayo Clinic Scottsdale

Scottsdale, Arizona, 85259, United States
Mount Sinai

New York, New York, 10029, United States
National Jewish Health

Denver, Colorado, 802006, United States
Northwestern Universtiy

Chicago, Illinois, 60611, United States
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Rush University

Chicago, Illinois, 60612, United States
University Hospitals Rainbow Babies & Children's Hospital

Cleveland, Ohio, 44106, United States
University of Arizona Tucson

Tucson, Arizona, 85724, United States
University of California Davis

Sacramento, California, 95817, United States
University of California San Diego: Airway Research & Clinical Trials Center

San Diego, California, 92103, United States
University of California San Diego: La Jolla Altman Clinical Translation Research Institute

San Diego, California, 92121, United States
University of California San Francisco

San Francisco, California, 94143, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Colorado Denver

Aurora, Colorado, 80045, United States
University of Illinois at Chicago

Chicago, Illinois, 60608, United States
University of Kansas

Kansas City, Kansas, 66160, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of South Florida

Tampa, Florida, 33613, United States
University of Wisconsin-Madison

Madison, Wisconsin, 53792, United States
Vanderbilt University

Nashville, Tennessee, 37232, United States
Wake Forest University

Winston-Salem, North Carolina, 27104, United States
Washington University

St Louis, Missouri, 63110, United States
Yale University

New Haven, Connecticut, 06520, United States