Daily vitamin d may slash lung risks in kids with sickle cell disease
NCT ID NCT04170348
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether taking vitamin D every day could reduce lung complications in children and teens with sickle cell disease. Lung problems like infections, asthma attacks, and acute chest syndrome are major causes of illness and death in this condition. Researchers gave daily or monthly vitamin D3 or a placebo to 58 participants aged 3-20 to see if it lowered the rate of these respiratory events.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vitamin D3 (cholecalciferol)
What this could lead to
If it works, daily vitamin D could become a simple, low-cost way to cut the risk of serious lung problems in children with sickle cell disease.
What could go wrong
This is a small Phase 2 trial with only 58 participants, so results may not apply to everyone. Vitamin D is generally safe, but high doses can cause side effects like high calcium levels.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Columbia University Medical Center
New York, New York, 10032, United States