Monthly capsule may keep wheezing away in babies at risk

NCT ID NCT02148796

Completed Prevention Sponsor: University of Arizona Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a monthly oral bacterial extract (Broncho-Vaxom) could prevent wheezing lower respiratory tract infections in infants aged 6-18 months who are at high risk for asthma. Over 800 participants received either the extract or a placebo for 10 days each month over two years. The goal was to see if the treatment could delay the first wheezing episode during a three-year follow-up period.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Broncho-Vaxom (bacterial extract)
What this could lead to: If it works, this could lead to a simple monthly treatment to prevent wheezing and asthma in high-risk infants.
What could go wrong: This is a Phase 2 trial, so results are still early. The treatment may not prove effective in larger or longer studies, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma Respiratory Sounds bronchiolitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA WHEEZING

Contacts and locations

Locations

Boston Children's Hospital, Harvard University

Boston, Massachusetts, 02115, United States
Children's National Health System

Washington D.C., District of Columbia, 20037, United States
Cincinnati Children's Hospital & Medical Center

Cincinnati, Ohio, 45229, United States
Columbia University

New York, New York, 10032, United States
Emory University

Atlanta, Georgia, 30322, United States
Phoenix Children's Hospital

Phoenix, Arizona, 85016, United States
University of Arizona

Tucson, Arizona, 85724, United States
University of California San Francisco, Benioff Children's Hospital

Oakland, California, 94609, United States
University of North Carolina

Chapel Hill, North Carolina, 27514, United States
University of Wisconsin

Madison, Wisconsin, 53792-4108, United States
Washington University

St Louis, Missouri, 63110, United States

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