Bronchiolitis

This large study tests an RSV vaccine given to pregnant women to see if it safely protects their babies from severe RSV infection in the first months of life. About 13,000 pregnant women in Africa will receive either the vaccine or a placebo. The study also closely monitors wheth…

This Phase 3 trial tests an oral drug called belumosudil in adults who have chronic lung allograft dysfunction (CLAD) after a bilateral lung transplant. CLAD is a form of chronic rejection that slowly worsens lung function. The study compares belumosudil to a placebo, both given …

This phase 2 trial tests whether the drug belumosudil can help people who develop bronchiolitis obliterans syndrome (BOS), a type of lung scarring, after a stem cell transplant. The study will enroll 45 participants with new or early-stage BOS. Participants will take belumosudil …

This study tests an inhaled drug called LAM-001 in 30 lung transplant patients who have developed chronic rejection (BOS). Participants will inhale LAM-001 or a placebo daily for 48 weeks. The goal is to see if the drug is safe and can slow the decline in lung function.

This study tests whether the drug belumosudil can prevent chronic lung allograft dysfunction (CLAD) in people who have had a lung transplant and show signs of rejection or inflammation on a biopsy. About 234 participants will receive either belumosudil or a placebo for 52 weeks, …

This study looks at whether monitoring the immune response to the cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to see if tracking CMV…

This early-phase study tests whether airway basal stem cells can safely help children with bronchiolitis obliterans, a chronic lung disease that narrows airways. About 12 children aged 28 days to 18 years will receive the cells via bronchoscopy. Researchers will check for improve…

This study tests whether the drug vimseltinib is safe and effective for adults with moderate to severe chronic graft-versus-host disease (cGVHD) who have not improved after at least two prior treatments. About 48 participants will take vimseltinib daily for up to two years. The g…

This study tests a drug called nintedanib in 20 people who developed a lung condition called bronchiolitis obliterans syndrome after a stem cell transplant. Participants take the drug daily for 12 months alongside their usual medications. The main goal is to see if the drug is sa…

This Phase 3 trial tests an inhaled drug called ARINA-1 in 100 people who have had a double lung transplant and are showing early signs of lung function loss. The goal is to see if adding ARINA-1 to standard care can prevent further decline in lung function and improve quality of…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely and accurately detect collagen buildup (scarring) in the lungs. Researchers will compare scans from healthy volunteers, lung cancer patients, and people with pulmonary fibrosis. The go…

This study is testing whether a special MRI using xenon gas can better detect bronchiolitis obliterans syndrome (BOS), a serious lung condition, in children who have had a stem-cell transplant. Fifteen children aged 6 to 17 will undergo breathing tests and the xenon MRI. The goal…

This study explores whether young children (ages 3 months to 2 years) with moderate bronchiolitis can be cared for at home through a structured home hospitalization program. Researchers will track how many children need oxygen therapy during home care and how well families manage…

This study tests whether a nose spray made from treated seawater can shorten the time babies (1 month to 1 year) have symptoms of bronchiolitis, compared to a standard saltwater spray. About 458 infants with their first, mild-to-moderate bout of bronchiolitis will take part. Pare…

This study looks at how well seawater nasal sprays work in everyday life for people with nasal and sinus issues like colds, allergies, or after surgery. About 1065 people of all ages, including pregnant women, will use the sprays and report their symptoms. The goal is to see if t…

This study compares two types of non-invasive breathing support for infants under 2 years old with bronchiolitis in the pediatric ICU. One method uses standard ventilation, while the other uses a smarter mode called NAVA that synchronizes with the baby's own breathing. The goal i…

This study looks at two ways to end high flow nasal cannula treatment in infants with acute bronchiolitis. One group stops the high flow immediately, while the other gradually reduces it. The goal is to see if immediate stopping shortens hospital stays without causing more breath…

This study follows 2,000 children who receive stem cell transplants to better understand and detect lung injuries that can occur after the procedure. Researchers will track participants for two years, collecting samples and health data to find ways to diagnose problems earlier. T…

This study is analyzing the exhaled breath of 5,000 people with lung or airway diseases to find unique molecular patterns. The goal is to better identify and distinguish different respiratory conditions and improve disease management. Participants simply provide breath samples, a…

This study tests whether alerts in electronic health records help doctors follow best-practice guidelines for bronchiolitis, a common lung infection in young children. About 8,000 children under 2 years old will take part. Doctors will receive either no alert, a gentle reminder, …

This study follows 250 people who have had a donor stem cell transplant to see if respiratory viruses lead to a lung condition called bronchiolitis obliterans syndrome (BOS). Participants use a handheld device at home to measure lung function and provide nasal swabs and blood sam…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at whether a common asthma drug, albuterol, helps babies with bronchiolitis (a lung infection). Researchers will give 400 children either albuterol or a placebo and check their breathing. They will also collect DNA samples to see if certain genes predict who gets…

This study is testing a new type of MRI that uses xenon gas to see how well the lungs are working in people who have had a bone marrow transplant. Researchers will scan 25 transplant patients with or without lung problems, plus 10 healthy volunteers. The goal is to see if this MR…

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this information to better understand imaging biomarkers and develop new analysis methods for CT and MRI scans. Participants must alr…

This study builds a research database and blood sample bank for veterans and contractors who served in Iraq or Afghanistan and have lung problems. Researchers will collect symptom and exposure information and store blood for future analysis. The goal is to better understand deplo…

This study will follow 1000 adults for up to 10 years, using a special type of CT scan (photon-counting) to look for lung nodules, tumors, and other lung conditions. Researchers will also use artificial intelligence to create a virtual copy of each person's lungs, called a 'digit…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This study looks at how often young children get ear infections from RSV, a common virus. Researchers will track 1900 children under 2 years old to see how many have RSV-related ear infections, with or without bronchiolitis. The goal is to better understand the burden of RSV in t…

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples (biopsy) and destroy abnormal tissue (ablation). Researchers will test different freezing times and temperatures to find the safest and most effective techniq…

This study looks at abnormal cells in the lungs of 15 people who developed bronchiolitis obliterans syndrome after a stem cell or lung transplant. Researchers want to understand these cells better so doctors can spot the disease earlier in future patients. Participants will have …

This study follows 200 infants hospitalized with lower respiratory tract infections (like bronchiolitis) to see if lung ultrasound and special breathing tests can help doctors predict how sick a child will get and who might develop asthma later. Researchers will track symptoms, h…

This study looks at two different approaches to help doctors and families avoid unnecessary follow-up visits after a child is hospitalized for bronchiolitis. About 2,700 children will take part to see which method works better at encouraging follow-up only when needed. The goal i…

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study tests whether computer-based decision support tools can help doctors reduce unnecessary antibiotic use in children with lower respiratory tract infections like pneumonia, bronchiolitis, and asthma flare-ups. Most of these infections are caused by viruses, not bacteria,…

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study tracks RSV (respiratory syncytial virus) in UK children under 2, after COVID-19 disrupted normal seasonal patterns. Researchers are monitoring when RSV appears, how severe it is, and whether older children are affected. The goal is to help hospitals prepare for surges …

This study follows 600 adults who have received a stem cell transplant to learn more about a lung condition called bronchiolitis obliterans syndrome. Researchers will track how common this lung problem is and how it develops over time. No new treatments are being tested; the goal…

This study is looking for better ways to predict if a lung transplant will be rejected. Researchers will collect blood samples from 244 lung transplant recipients over time and analyze them using advanced techniques. The goal is to create a model that can identify early signs of …

This study looks at whether a special CT scan analysis called parametric response mapping (PRM) can detect early signs of chronic lung disease in people who have had a stem cell transplant. Researchers will follow 375 patients for one year to see if PRM patterns predict lung func…

This pilot study is testing a new ultrasound tool that measures how much the lungs stretch (strain) in patients on breathing machines in the ICU. The goal is to collect initial data from 10 adults with lung disease to see if this technique can help doctors better monitor and prev…