New drug aims to stop lung transplants from failing

NCT ID NCT06476132

Recruiting now Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study tests whether the drug belumosudil can prevent chronic lung allograft dysfunction (CLAD) in people who have had a lung transplant and show signs of rejection or inflammation on a biopsy. About 234 participants will receive either belumosudil or a placebo for 52 weeks, in addition to their usual anti-rejection medications. The goal is to see if the drug can delay or prevent CLAD, the need for another transplant, or death.

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Conditions

The condition(s) this trial relates to.

acute lung injury Organizing Pneumonia bronchiolitis obliterans syndrome prevention target transplant-related bronchiolitis obliterans prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG TRANSPLANT

Contacts and locations

Locations

Cincinnati Children's Hospital Medical Center (Site #: 71017)
RECRUITING

Cincinnati, Ohio, 45229, United States
Cleveland Clinic (Site #: 71101)
RECRUITING

Cleveland, Ohio, 44195, United States
Duke University (Site #: 71139)
RECRUITING

Durham, North Carolina, 27710, United States
Johns Hopkins (Site #: 71119)
RECRUITING

Baltimore, Maryland, 21287, United States
NYU Langone Health (Site #: 71177)
RECRUITING

New York, New York, 10016, United States
Stanford University (Site #: 71141)
RECRUITING

Palo Alto, California, 94304, United States
University Health Network/Toronto General Hospital (Site #: 71121)
RECRUITING

Toronto, Ontario, Canada
University of California, Los Angeles (Site #: 71123)
RECRUITING

Los Angeles, California, 90095, United States
University of Minnesota (Site 71151)
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Pennsylvania (Site #: 71111)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Vanderbilt University Medical Center (Site #: 71174)
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University (Site #: 71157)
RECRUITING

St Louis, Missouri, 63130, United States

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