New xenon MRI could spot lung damage in kids after transplant

NCT ID NCT04391335

Recruiting now Diagnosis Sponsor: The Hospital for Sick Children Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a special MRI using xenon gas can better detect bronchiolitis obliterans syndrome (BOS), a serious lung condition, in children who have had a stem-cell transplant. Fifteen children aged 6 to 17 will undergo breathing tests and the xenon MRI. The goal is to see if this new imaging method can diagnose BOS more accurately than standard breathing tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: xenon gas
What this could lead to: If successful, this could provide a more accurate, non-invasive way to diagnose bronchiolitis obliterans syndrome early in children after stem-cell transplant.
What could go wrong: This is a very small, early study (15 children) focused on testing a diagnostic tool, not a treatment. The MRI with xenon gas may not prove better than current breathing tests.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bronchiolitis obliterans syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRONCHIOLITIS OBLITERANS SYNDROME

Contacts and locations

Locations

The Hospital for Sick Children
RECRUITING

Toronto, Ontario, M5G 1X8, Canada

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